FMLP induced chemokine gene expression in HMC-1 cells

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PAK1

RAC1

PAK1

P47 phox

PAK1

RAC1

NFkB

IkBa

NFkB

DNA double helix

NFkB

PKC isoforms

PLcB

DAG

MAPK

MEK3-MEK6

MAPK

other targets ?

RAF1

MEK-1

RAF1

RAS

RAC1

RAC1

RAC1

PAK1

RAC1

p67 phox

RAC1

p47 phox

NFATc

NFATc

NFATc

Calcineurin

CAMK1

RAC1

CAMK1

RAS

FPR1

fMLP

FPR1

Ga1b

FPR1

Gb

FPR1

Gr