FMLP induced chemokine gene expression in HMC-1 cells
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|
|
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PAK1 |
RAC1 |
|
PAK1 |
P47 phox |
|
PAK1 |
RAC1 |
|
NFkB |
IkBa |
|
NFkB |
DNA double helix |
|
NFkB |
PKC isoforms |
|
PLcB |
DAG |
|
MAPK |
MEK3-MEK6 |
|
MAPK |
other targets ? |
|
RAF1 |
MEK-1 |
|
RAF1 |
RAS |
|
RAC1 |
RAC1 |
|
RAC1 |
PAK1 |
|
RAC1 |
p67 phox |
|
RAC1 |
p47 phox |
|
NFATc |
NFATc |
|
NFATc |
Calcineurin |
|
CAMK1 |
RAC1 |
|
CAMK1 |
RAS |
|
FPR1 |
fMLP |
|
FPR1 |
Ga1b |
|
FPR1 |
Gb |
|
FPR1 |
Gr |