Erythropoietin mediated neuroprotection through NF-kB
From Opengenome.net
EPO |
EPO R |
EPO |
DNA double helix |
NFkB(p65 + p50 Complex) |
JAK2-EPOR-EPO Complex |
NFkB(p65 + p50 Complex) |
IkBa |
NFkB(p65 + p50 Complex) |
Proteolysis |
ARNT |
HIF-1a |
ARNT |
DNA double helix |
ARNT |
Hypoxia |
EPO R |
EPO |
EPO R |
JAK 2 |
HIF1A |
ARNT |
JAK2 |
EPO R |
JAK2 |
NFkB |
TRANSCRIPTION FACTOR
=NFkB, p65, p50, ARNT, HIF-1a