Erythropoietin mediated neuroprotection through NF-kB
From Opengenome.net
|
EPO |
EPO R |
|
EPO |
DNA double helix |
|
NFkB(p65 + p50 Complex) |
JAK2-EPOR-EPO Complex |
|
NFkB(p65 + p50 Complex) |
IkBa |
|
NFkB(p65 + p50 Complex) |
Proteolysis |
|
ARNT |
HIF-1a |
|
ARNT |
DNA double helix |
|
ARNT |
Hypoxia |
|
EPO R |
EPO |
|
EPO R |
JAK 2 |
|
HIF1A |
ARNT |
|
JAK2 |
EPO R |
|
JAK2 |
NFkB |
TRANSCRIPTION FACTOR
=NFkB, p65, p50, ARNT, HIF-1a
