Interleukin 1~25

Cytokine.  MW(kDa).  Synonyms	Sources	Activity
Interleukin-1 (IL-1) IL-1α; 17.5, IL-1β; 17.3, Lymphocyte-activating factor (LAF); mononuclear cell factor (MCF); endogenous pyrogen (EP).	Many cell types including monocytes, macrophages, dendritic cells, T and B cells, NK cells, and non-immune system cells such as vascular epithelium, fibroblast, and some smooth muscle cells	IL-1 displays a wide variety of biological activities on many different cell types including T cells, B cells, and monocytes. Receptor for IL-1 are also found on the other leukocytes including eosinophils and dendritic cells as well as on nonimmune system cells such as fibroblasts, vascular endothelial cells, and some cells of the nervous system. The in vivo effects of IL-1 include induction of fever, the acute phase response, and stimulation of neutrophil production.
Interleukin-2 (IL-2) 15-20. T cell growth factor (TCGF)	T cells	Stimulates growth and differentiation of T cells, B cells, and NK cells
Interleukin-3 (IL-3) 15.1(monomer), 30(dimer). Multi-colony-stimulating factor(M-CSF); hematopoietic cell growth factor (HCGF); mast cell growth factor (MCGF)	Activated T cells, mast cells and eosinophils	Growth factor for hematopoietic cells and lymphocytes; stimulates colony formation in neutrophils, eosinophil, basophil, mast cell, erythroid, megakaryocyte, and monocytic lineages but not in lymphocytes
Interleukin-4 (IL-4) 15-19. B cell-stimulating factor 1 (BSF-1)	Mast cells, T cells, bone marrow stromal cells	Promotes growth and development of B and T cells, and cells of the monocytic lineage. Also affects cells outside the immune system, including endothelial cells and fibroblasts
Interleukin-5 (IL-5) 45. Eosinophil differentiation factor (EDF), eosinophil colony-stimulating factor (E-CSF)	Mast cells, T cells, eosinophils	Induces eosinophil formation and differentiation
Interleukin-6 (IL-6) 26. B cell stimulatory factor 2 (BSF-2), hybridoma/plasmacytoma growth factor (HPGF), hepatocyte-stimulating factor (HSF)	T cells, B cells, several non-lymphoid cells including macrophages, bone marrow stromal cells, fibroblasts, endothelial cells, and astrocytes	Regulate B and T cell functions; in vivo effects on hematopoiesis; inducer of the acute phase response
Interleukin-7 (IL-7) 20-28. Pre-B-cell growth factor, lymphopoietin-1 (LP-1)	Bone marrow stromal cells, thymic stromal cells, and spleen cells	Growth factor for T and B cell progenitors
Interleukin-8 (IL-8) 6-8. Neutrophil-attractant/activating protein (NAP-1), neutrophil-activating factor (NAF), and granulocyte chemotactic protein (GCAP).	Many cell types including monocytes, lymphocytes, granulocytes, and nonimmune system cells such as fibroblasts, endothelial cells, hepatocytes, and others	Chemokine that cunctions primarily as a chemo-attractant and activator of neutrophils; also attracts basophils and some subpopulations of lymphocytes; has angiogenic activity
Interleukin-9 (IL-9) 32-39. P40; T cell growth factor Ⅲ.	IL-2 activated T helper cell populations	Stimulates proliferation of T lymphocytes and erythroid precursors
Interleukin-10 (IL-10) 35-40. Cytokine synthesis inhibitory factor (CSIF)	Activated subsets of CD4+ and CD8+ T cells	Stimulates or enhances proliferation of B cells, thymocytes, and mast cells. In co-operation with TGF-β, stimulates IgA synthesis and secretion by human B cells; antagonizes generation of the Th1 subset of helper T cells
Interleukin-11 (IL-11)
Interleukin-12 (IL-12)
Interleukin-13 (IL-13)
Interleukin-14 (IL-14)
Interleukin-15 (IL-15)
Interleukin-16 (IL-16)
Interleukin-17 (IL-17)
Interleukin-18 (IL-18)
Interleukin-19 (IL-19)
Interleukin-20 (IL-20)
Interleukin-21 (IL-21)
Interleukin-22 (IL-22)
Interleukin-23 (IL-23)
Interleukin-24 (IL-24)
Interleukin-25 (IL-25)