Difference between revisions of "CD61-75"

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         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD63</strong></td>
 
             <td><strong>&nbsp;CD63</strong></td>
−
             <td>&nbsp;160</td>
+
             <td>&nbsp;40-60</td>
−
             <td>&nbsp;&nbsp;&alpha;-2 integrin chain, GPIa VLA-2 &alpha; chain</td>
+
             <td>&nbsp;&nbsp;LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA)</td>
−
             <td>&nbsp;B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts</td>
+
             <td>&nbsp;Platelets, endothelium, degranulated neutrophils, monocytes, macrophages endothelium</td>
−
             <td>&nbsp;Integrin that associates with CD29, binds collagen, laminin-1</td>
+
             <td>&nbsp;Not known</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD64</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD64</strong></td>
−
             <td bgcolor="#cccccc">&nbsp;125, 30 </td>
+
             <td bgcolor="#cccccc">&nbsp;72</td>
−
             <td bgcolor="#cccccc">&nbsp;&alpha;-3 integrin chain, VLA-3 &alpha; chain</td>
+
             <td bgcolor="#cccccc">&nbsp;Fc&gamma;\RI, FCRI</td>
−
             <td bgcolor="#cccccc">&nbsp;B cells, many adherent cells</td>
+
             <td bgcolor="#cccccc">&nbsp;Monocytes, macrophages, bood and germinal-center dendritic cells, PMN activated by IFN-&gamma; or G-CSF, early myeloid-lineage cells</td>
−
             <td bgcolor="#cccccc">&nbsp;Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin</td>
+
             <td bgcolor="#cccccc">&nbsp;Phagocytosis: receptor-mediated endocytosis of IgG-antigen complexes; antigen capture for presentation to T cells; antibody-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediates</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD65</strong></td>
 
             <td><strong>&nbsp;CD65</strong></td>
−
             <td>&nbsp;145</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;&alpha;-4 integrin chain, VLA-4 &alpha; chain</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (&alpha;4&beta;1 and &alpha;4&beta;7) and MAdCAM-1(&alpha;4&beta;7) and attachment to extracellular matrix proteins fibronectin (&alpha;4&beta;1 and &alpha;4&beta;7) and thrombospondin (&alpha;4&beta;1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD65s</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD65s</strong></td>
−
             <td bgcolor="#cccccc">&nbsp;135</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;&alpha;-5 integrin chain, FNR &alpha; chain, VLA-5 &alpha; chain</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Many cell types, including memory T cells, monocytes, platelets</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Integrin that associates with CD29, binds fibronectin, invasin</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD66a</strong></td>
 
             <td><strong>&nbsp;CD66a</strong></td>
−
             <td>&nbsp;125, 25</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;&alpha;-6 integrinchain, platelet gpI, VLA-6 &alpha; chain</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;T cells, monocytes, platelets, megakaryocytes, trophoblasts</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Integrin that associates with CD29, binds laminin, invasin, merosine</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD66b</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD66b</strong></td>
−
             <td bgcolor="#cccccc">130</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Intercellular molecule-3, ICAM-3</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Leukocytes of all lineages</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-&beta;-dependent adhesion</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD66c</strong></td>
 
             <td><strong>&nbsp;CD66c</strong></td>
−
             <td>&nbsp;125</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;VNR-&alpha; chain, &alpha; V integrin chain, vitronsctin receptor; forms &alpha;-V integrin by association with CD61&nbsp;</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Platelets, megakaryocytes</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Subunit of &alpha;-V integrin, which binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and probably apoptotic cells</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD66d</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD66d</strong></td>
−
             <td bgcolor="#cccccc">&nbsp;25-29</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;CAMPATH-1, HE5</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Thymocytes, lymphocytes, monocytes, macrophages, epithelial cells lining male reproductive tract</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Not known</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD66e</strong></td>
 
             <td><strong>&nbsp;CD66e</strong></td>
−
             <td>&nbsp;32-42</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;MRC OX44</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Leukocytes </td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Signal transduction; crosslinking promotes activation of human B cells</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD66f</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD66f</strong></td>
−
             <td bgcolor="#cccccc">&nbsp;90, 75-115</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Intercellular adhesion molecule-1 (ICAM-1)</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and for RBCs infected with malarial parasites</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD68</strong></td>
 
             <td><strong>&nbsp;CD68</strong></td>
−
             <td>&nbsp;70, 55</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Decay accelerating factor (DAF)</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Most cells</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Protective barrier against inappropriate complement activation and deposition on plasma membranes</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD69</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD69</strong></td>
−
             <td bgcolor="#cccccc">&nbsp;175-220</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Leu-19, NKH1, neural cell adhesion molecule (NCAM)</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">Human NK cellls, a subset of CD4+ and CD8+ T cells</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Not known for the immune system; adhesion molecule for cells of the nervous system</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD70</strong></td>
 
             <td><strong>&nbsp;CD70</strong></td>
 
             <td>&nbsp;</td>
 
             <td>&nbsp;</td>
−
             <td>&nbsp;HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins&nbsp;</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;NK cells; subsets of T cells, B cells, and monocytes&nbsp;</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;Not known&nbsp;</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc">&nbsp;<strong>CD71</strong></td>
 
             <td bgcolor="#cccccc">&nbsp;<strong>CD71</strong></td>
−
             <td bgcolor="#cccccc">&nbsp;55-70</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Lymphocyte function-associated antigen 3 (LFA-3)&nbsp;</td>
+
             <td bgcolor="#cccccc">&nbsp;&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Many hematopoeitic and non-hematopoeitic celltypes&nbsp;</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells&nbsp;</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td><strong>&nbsp;CD72</strong></td>
 
             <td><strong>&nbsp;CD72</strong></td>
−
             <td>&nbsp;18-25</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin&nbsp;</td>
+
             <td>&nbsp;</td>
−
             <td>&nbsp;&nbsp;Many hematopoeitic and non-hematopoeitic celltypes&nbsp;</td>
+
             <td>&nbsp;&nbsp;</td>
−
             <td>&nbsp;Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion</td>
+
             <td>&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD73</strong></td>
 
             <td bgcolor="#cccccc"><strong>&nbsp;CD73</strong></td>
 
             <td bgcolor="#cccccc">&nbsp;</td>
 
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;9-O-acetyl-GD3; carbohydrate modification found on some gangliosides</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Subset of T cells, platelets, thymic epithelium, activated keratinocytes,&nbsp;synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes&nbsp;</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
−
             <td bgcolor="#cccccc">&nbsp;Possible contributor to co-stimulatory/comitogenic signals for T cells&nbsp;</td>
+
             <td bgcolor="#cccccc">&nbsp;</td>
 
         </tr>
 
         </tr>
 
         <tr>
 
         <tr>

Revision as of 17:59, 7 September 2006

 CD antigen

 MW.(kDa) 

 Synonyms & Properties

 Leukocyte expression  

 Function
 CD61  110  CD61A, GPⅡb/Ⅲa, β3 integrin chain  Platelets, megakaryocytes, macrophages  Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)
 CD62E  140  E-selectin, ELAM-1, LECAM-2   Acutely activated endothelium, chronic inflammatory lesions of skin and synovium   Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites
 CD62L  65  L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1  Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes  Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites
 CD62P  120  P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)  Endothelium, platelets, megakaryocytes  Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation
 CD63  40-60   LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA)  Platelets, endothelium, degranulated neutrophils, monocytes, macrophages endothelium  Not known
 CD64  72  Fcγ\RI, FCRI  Monocytes, macrophages, bood and germinal-center dendritic cells, PMN activated by IFN-γ or G-CSF, early myeloid-lineage cells  Phagocytosis: receptor-mediated endocytosis of IgG-antigen complexes; antigen capture for presentation to T cells; antibody-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediates
 CD65        
 CD65s        
 CD66a        
 CD66b        
 CD66c        
 CD66d        
 CD66e        
 CD66f        
 CD68        
 CD69        
 CD70        
 CD71         
 CD72         
 CD73        
 CD74        
 CDw75        
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