0
edits
Changes
From Opengenome.net
no edit summary
<table style="WIDTH: 740px; HEIGHT: 348px" cellspacing="1" cellpadding="1" width="740" summary="" border="1">
<tbody>
<tr>
<td bgcolor="#999999">
<p align="center"><strong> <font color="#ffff00">CD antigen</font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> MW.(kDa) </font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> Synonyms & Properties</font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> Leukocyte expression </font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> Function</font></strong></p>
</td>
</tr>
<tr>
<td><strong> CD61</strong></td>
<td> 110</td>
<td> CD61A, GPⅡb/Ⅲa, β3 integrin chain</td>
<td> Platelets, megakaryocytes, macrophages</td>
<td> Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD62E</strong></td>
<td bgcolor="#cccccc"> 140</td>
<td bgcolor="#cccccc"> E-selectin, ELAM-1, LECAM-2</td>
<td bgcolor="#cccccc"> Acutely activated endothelium, chronic inflammatory lesions of skin and synovium </td>
<td bgcolor="#cccccc"> Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites</td>
</tr>
<tr>
<td><strong> CD62L</strong></td>
<td> 65</td>
<td> L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1</td>
<td> Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes</td>
<td> Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD62P</strong></td>
<td bgcolor="#cccccc"> 120</td>
<td bgcolor="#cccccc"> P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)</td>
<td bgcolor="#cccccc"> Endothelium, platelets, megakaryocytes</td>
<td bgcolor="#cccccc"> Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation</td>
</tr>
<tr>
<td><strong> CD63</strong></td>
<td> 160</td>
<td> α-2 integrin chain, GPIa VLA-2 α chain</td>
<td> B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts</td>
<td> Integrin that associates with CD29, binds collagen, laminin-1</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD64</strong></td>
<td bgcolor="#cccccc"> 125, 30 </td>
<td bgcolor="#cccccc"> α-3 integrin chain, VLA-3 α chain</td>
<td bgcolor="#cccccc"> B cells, many adherent cells</td>
<td bgcolor="#cccccc"> Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin</td>
</tr>
<tr>
<td><strong> CD65</strong></td>
<td> 145</td>
<td> α-4 integrin chain, VLA-4 α chain</td>
<td> Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils</td>
<td> Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4β1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD65s</strong></td>
<td bgcolor="#cccccc"> 135</td>
<td bgcolor="#cccccc"> α-5 integrin chain, FNR α chain, VLA-5 α chain</td>
<td bgcolor="#cccccc"> Many cell types, including memory T cells, monocytes, platelets</td>
<td bgcolor="#cccccc"> Integrin that associates with CD29, binds fibronectin, invasin</td>
</tr>
<tr>
<td><strong> CD66a</strong></td>
<td> 125, 25</td>
<td> α-6 integrinchain, platelet gpI, VLA-6 α chain</td>
<td> T cells, monocytes, platelets, megakaryocytes, trophoblasts</td>
<td> Integrin that associates with CD29, binds laminin, invasin, merosine</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD66b</strong></td>
<td bgcolor="#cccccc">130</td>
<td bgcolor="#cccccc"> Intercellular molecule-3, ICAM-3</td>
<td bgcolor="#cccccc"> Leukocytes of all lineages</td>
<td bgcolor="#cccccc"> Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-β-dependent adhesion</td>
</tr>
<tr>
<td><strong> CD66c</strong></td>
<td> 125</td>
<td> VNR-α chain, α V integrin chain, vitronsctin receptor; forms α-V integrin by association with CD61 </td>
<td> Platelets, megakaryocytes</td>
<td> Subunit of α-V integrin, which binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and probably apoptotic cells</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD66d</strong></td>
<td bgcolor="#cccccc"> 25-29</td>
<td bgcolor="#cccccc"> CAMPATH-1, HE5</td>
<td bgcolor="#cccccc"> Thymocytes, lymphocytes, monocytes, macrophages, epithelial cells lining male reproductive tract</td>
<td bgcolor="#cccccc"> Not known</td>
</tr>
<tr>
<td><strong> CD66e</strong></td>
<td> 32-42</td>
<td> MRC OX44</td>
<td> Leukocytes </td>
<td> Signal transduction; crosslinking promotes activation of human B cells</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD66f</strong></td>
<td bgcolor="#cccccc"> 90, 75-115</td>
<td bgcolor="#cccccc"> Intercellular adhesion molecule-1 (ICAM-1)</td>
<td bgcolor="#cccccc"> Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells</td>
<td bgcolor="#cccccc"> Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and for RBCs infected with malarial parasites</td>
</tr>
<tr>
<td><strong> CD68</strong></td>
<td> 70, 55</td>
<td> Decay accelerating factor (DAF)</td>
<td> Most cells</td>
<td> Protective barrier against inappropriate complement activation and deposition on plasma membranes</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD69</strong></td>
<td bgcolor="#cccccc"> 175-220</td>
<td bgcolor="#cccccc"> Leu-19, NKH1, neural cell adhesion molecule (NCAM)</td>
<td bgcolor="#cccccc">Human NK cellls, a subset of CD4+ and CD8+ T cells</td>
<td bgcolor="#cccccc"> Not known for the immune system; adhesion molecule for cells of the nervous system</td>
</tr>
<tr>
<td><strong> CD70</strong></td>
<td> </td>
<td> HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins </td>
<td> NK cells; subsets of T cells, B cells, and monocytes </td>
<td> Not known </td>
</tr>
<tr>
<td bgcolor="#cccccc"> <strong>CD71</strong></td>
<td bgcolor="#cccccc"> 55-70</td>
<td bgcolor="#cccccc"> Lymphocyte function-associated antigen 3 (LFA-3) </td>
<td bgcolor="#cccccc"> Many hematopoeitic and non-hematopoeitic celltypes </td>
<td bgcolor="#cccccc"> Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells </td>
</tr>
<tr>
<td><strong> CD72</strong></td>
<td> 18-25</td>
<td> IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin </td>
<td> Many hematopoeitic and non-hematopoeitic celltypes </td>
<td> Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD73</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> 9-O-acetyl-GD3; carbohydrate modification found on some gangliosides</td>
<td bgcolor="#cccccc"> Subset of T cells, platelets, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes </td>
<td bgcolor="#cccccc"> Possible contributor to co-stimulatory/comitogenic signals for T cells </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD74</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CDw75</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
</tbody>
</table>
<tbody>
<tr>
<td bgcolor="#999999">
<p align="center"><strong> <font color="#ffff00">CD antigen</font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> MW.(kDa) </font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> Synonyms & Properties</font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> Leukocyte expression </font></strong></p>
</td>
<td bgcolor="#999999">
<p align="center"><strong><font color="#ffff00"> Function</font></strong></p>
</td>
</tr>
<tr>
<td><strong> CD61</strong></td>
<td> 110</td>
<td> CD61A, GPⅡb/Ⅲa, β3 integrin chain</td>
<td> Platelets, megakaryocytes, macrophages</td>
<td> Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD62E</strong></td>
<td bgcolor="#cccccc"> 140</td>
<td bgcolor="#cccccc"> E-selectin, ELAM-1, LECAM-2</td>
<td bgcolor="#cccccc"> Acutely activated endothelium, chronic inflammatory lesions of skin and synovium </td>
<td bgcolor="#cccccc"> Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites</td>
</tr>
<tr>
<td><strong> CD62L</strong></td>
<td> 65</td>
<td> L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1</td>
<td> Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes</td>
<td> Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD62P</strong></td>
<td bgcolor="#cccccc"> 120</td>
<td bgcolor="#cccccc"> P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)</td>
<td bgcolor="#cccccc"> Endothelium, platelets, megakaryocytes</td>
<td bgcolor="#cccccc"> Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation</td>
</tr>
<tr>
<td><strong> CD63</strong></td>
<td> 160</td>
<td> α-2 integrin chain, GPIa VLA-2 α chain</td>
<td> B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts</td>
<td> Integrin that associates with CD29, binds collagen, laminin-1</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD64</strong></td>
<td bgcolor="#cccccc"> 125, 30 </td>
<td bgcolor="#cccccc"> α-3 integrin chain, VLA-3 α chain</td>
<td bgcolor="#cccccc"> B cells, many adherent cells</td>
<td bgcolor="#cccccc"> Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin</td>
</tr>
<tr>
<td><strong> CD65</strong></td>
<td> 145</td>
<td> α-4 integrin chain, VLA-4 α chain</td>
<td> Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils</td>
<td> Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4β1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD65s</strong></td>
<td bgcolor="#cccccc"> 135</td>
<td bgcolor="#cccccc"> α-5 integrin chain, FNR α chain, VLA-5 α chain</td>
<td bgcolor="#cccccc"> Many cell types, including memory T cells, monocytes, platelets</td>
<td bgcolor="#cccccc"> Integrin that associates with CD29, binds fibronectin, invasin</td>
</tr>
<tr>
<td><strong> CD66a</strong></td>
<td> 125, 25</td>
<td> α-6 integrinchain, platelet gpI, VLA-6 α chain</td>
<td> T cells, monocytes, platelets, megakaryocytes, trophoblasts</td>
<td> Integrin that associates with CD29, binds laminin, invasin, merosine</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD66b</strong></td>
<td bgcolor="#cccccc">130</td>
<td bgcolor="#cccccc"> Intercellular molecule-3, ICAM-3</td>
<td bgcolor="#cccccc"> Leukocytes of all lineages</td>
<td bgcolor="#cccccc"> Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-β-dependent adhesion</td>
</tr>
<tr>
<td><strong> CD66c</strong></td>
<td> 125</td>
<td> VNR-α chain, α V integrin chain, vitronsctin receptor; forms α-V integrin by association with CD61 </td>
<td> Platelets, megakaryocytes</td>
<td> Subunit of α-V integrin, which binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and probably apoptotic cells</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD66d</strong></td>
<td bgcolor="#cccccc"> 25-29</td>
<td bgcolor="#cccccc"> CAMPATH-1, HE5</td>
<td bgcolor="#cccccc"> Thymocytes, lymphocytes, monocytes, macrophages, epithelial cells lining male reproductive tract</td>
<td bgcolor="#cccccc"> Not known</td>
</tr>
<tr>
<td><strong> CD66e</strong></td>
<td> 32-42</td>
<td> MRC OX44</td>
<td> Leukocytes </td>
<td> Signal transduction; crosslinking promotes activation of human B cells</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD66f</strong></td>
<td bgcolor="#cccccc"> 90, 75-115</td>
<td bgcolor="#cccccc"> Intercellular adhesion molecule-1 (ICAM-1)</td>
<td bgcolor="#cccccc"> Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells</td>
<td bgcolor="#cccccc"> Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and for RBCs infected with malarial parasites</td>
</tr>
<tr>
<td><strong> CD68</strong></td>
<td> 70, 55</td>
<td> Decay accelerating factor (DAF)</td>
<td> Most cells</td>
<td> Protective barrier against inappropriate complement activation and deposition on plasma membranes</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD69</strong></td>
<td bgcolor="#cccccc"> 175-220</td>
<td bgcolor="#cccccc"> Leu-19, NKH1, neural cell adhesion molecule (NCAM)</td>
<td bgcolor="#cccccc">Human NK cellls, a subset of CD4+ and CD8+ T cells</td>
<td bgcolor="#cccccc"> Not known for the immune system; adhesion molecule for cells of the nervous system</td>
</tr>
<tr>
<td><strong> CD70</strong></td>
<td> </td>
<td> HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins </td>
<td> NK cells; subsets of T cells, B cells, and monocytes </td>
<td> Not known </td>
</tr>
<tr>
<td bgcolor="#cccccc"> <strong>CD71</strong></td>
<td bgcolor="#cccccc"> 55-70</td>
<td bgcolor="#cccccc"> Lymphocyte function-associated antigen 3 (LFA-3) </td>
<td bgcolor="#cccccc"> Many hematopoeitic and non-hematopoeitic celltypes </td>
<td bgcolor="#cccccc"> Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells </td>
</tr>
<tr>
<td><strong> CD72</strong></td>
<td> 18-25</td>
<td> IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin </td>
<td> Many hematopoeitic and non-hematopoeitic celltypes </td>
<td> Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD73</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> 9-O-acetyl-GD3; carbohydrate modification found on some gangliosides</td>
<td bgcolor="#cccccc"> Subset of T cells, platelets, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes </td>
<td bgcolor="#cccccc"> Possible contributor to co-stimulatory/comitogenic signals for T cells </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD74</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CDw75</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
</tbody>
</table>
