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<td bgcolor="#cccccc"><strong> CD40</strong></td>
<td bgcolor="#cccccc"> 48 (monomer)</td> <td bgcolor="#cccccc"> Bp50 </td> <td bgcolor="#cccccc"> B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors </td> <td bgcolor="#cccccc"> Roles in B-cell growth, differentiation, and isotype-switching; apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of adhesion molecules on dendritic cells</td>
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<td><strong> CD41</strong></td>
<td> αβ dimer: α, 125; β, 122 </td> <td> GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa </td> <td> Platelets, megakaryocytes</td> <td> Subunit of platelet fibrinogen receptor, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for von Willebrand factor, fibronectin, and thrombospondin </td>
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<td bgcolor="#cccccc"><strong> CD42a,b,c,d</strong></td>
<td bgcolor="#cccccc"> a, 23; <br /> b, 135,23; <br /> c, 22;</td> <td bgcolor="#cccccc"> a, GPIX; b, GPIb-α; c, GPIb-β; d, GPV</td> <td bgcolor="#cccccc"> Platelets, megakaryocytes </td> <td bgcolor="#cccccc"> Adhesion of platelets to endothelium; amplification of platelet response to thrombin </td>
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<td><strong> CD43</strong></td>
<td> 95-115 in <br /> T cells, 115-135 in neutrophils</td> <td> gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin </td> <td> All leukocytes except most resting B cells </td> <td> Possible anti-adhesive ("barrier") molecule mediating repulsion between leukocytes and other cells </td>
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<td bgcolor="#cccccc"><strong> CD44</strong></td>
<td bgcolor="#cccccc"> 85</td> <td bgcolor="#cccccc"> ECMR Ⅲ, H-CAM, HUTCH-1, Hermes, Lu, Pgp-1, gp85 </td> <td bgcolor="#cccccc"> Surface of most cell types </td> <td bgcolor="#cccccc"> Adhesion molecule mediating leukocyte attachment and homing to peripheral lymphoid organs and sites of inflammation </td>
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<td><strong> CD44R</strong></td>
<td> 85-250 in epithelial cells; 85-200 in lymphocytes</td> <td> CD44v, CD44v9; heterogenous group of CD44 variant isoforms designated by the variant exons that they include (v2-v10 in humans) </td> <td> Epithelial cells and monocytes (constitutively), activated leukocytes </td> <td> Possible role (particulary for CD44v6) in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation </td>
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<td bgcolor="#cccccc"><strong> CD45</strong></td>
<td bgcolor="#cccccc"> 210, 220, 180, 200</td> <td bgcolor="#cccccc"> Leukocyte common antigen (LCA), T200, EC 3.1.3.4; many dofferent isoforms with different molecular weights, e.g..<br /> B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO </td> <td bgcolor="#cccccc"> All hematopoeitic cells; different isoforms characteristic of differentiated subsets of various hematopoeitic cells</td> <td bgcolor="#cccccc"> Essential role in T-and B-cell antigen-receptor-mediated activation; possible role in receptor-mediated activation in other leukocytes </td>
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