0
edits
Changes
From Opengenome.net
no edit summary
<tr>
<td><strong> CD31</strong></td>
<td> 130-140</td> <td> GPiia, endocam, platelet endothelial cell adhesion molecule <br /> (PECAM-1) </td> <td> Endothelial cells, platelets, monocytes, neutrophils, NK cells, subsets of T cells </td> <td> Adhesion molecule </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD32</strong></td>
<td bgcolor="#cccccc"> 40</td> <td bgcolor="#cccccc"> FCRⅡ, FcγRⅡ </td> <td bgcolor="#cccccc"> B cells, granulocytes, monocytes</td> <td bgcolor="#cccccc"> Receptor for Fc portion of antigen-antibody-complexed IgG molecules </td>
</tr>
<tr>
<td><strong> CD33</strong></td>
<td> 67</td> <td> gp67, p67</td> <td> Monocytes, myeloid precursors </td> <td> Sialic acid-dependent cytoadhesion molecule, a sialoadhesion </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD34</strong></td>
<td bgcolor="#cccccc"> 40 (based on amino seq.)</td> <td bgcolor="#cccccc"> gp105-120 </td> <td bgcolor="#cccccc"> Early lymphohematopoeitic stem and progenitor cells, small-vessel endothelial cells, embryonic fibroblasts, some cells in fetal and adult nervous tissue </td> <td bgcolor="#cccccc"> Cell-cell adhesion molecule </td>
</tr>
<tr>
<td><strong> CD35</strong></td>
<td> Many forms: 160, 190, 220, 250, 165, 195, 225, 255</td> <td> C3bR, C4bR, complement receptor type one (CR1), immune adherence receptor </td> <td> Erythrocytes, neutrophils, monocytes, eosinophils, B cells </td> <td> Receptor for C4b/C3b particles, mediating their adherence and phagocytosis; facilitator of C3b and C4b cleavage, thus limiting complement activation </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD36</strong></td>
<td bgcolor="#cccccc"> 88-113 (platelet form)</td> <td bgcolor="#cccccc"> GPⅢb, GPIV, OKM5-antigen, PASIV </td> <td bgcolor="#cccccc"> Platelets, mature monocytes / macrophages, endothelial cells </td> <td bgcolor="#cccccc"> Adhesion molecule in platelet adhesion and aggregation, and in platelet-monocyte or platelet-tumor cell interaction; molecule for recognition of apoptotic neutrophils; scavenger receptor for oxidized LDL </td>
</tr>
<tr>
<td><strong> CD37</strong></td>
<td> 40-52</td> <td> gp52-50</td> <td> B cells; low levels on T cells, neutrophils, granulocytes, and monocytes </td> <td> Role in signal transduction </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD38</strong></td>
<td bgcolor="#cccccc"> 45</td> <td bgcolor="#cccccc"> T10 </td> <td bgcolor="#cccccc"> Early-stage B and T cells, germinal-center B cells, plasma cells </td> <td bgcolor="#cccccc"> NAD glycohydrolase </td>
</tr>
<tr>
<td><strong> CD39</strong></td>
<td> 40-52</td> <td> Bp50 </td> <td> B cells, T cells, neutrophils, granulocytes, monocytes </td> <td> Role in signal transduction </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD40</strong></td>
<td bgcolor="#cccccc"> 48 (monomer)</td> <td bgcolor="#cccccc"> Bp50 </td> <td bgcolor="#cccccc"> B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors </td> <td bgcolor="#cccccc"> Roles in B-cell growth, differentiation, and isotype-switching; apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of adhesion molecules on dendritic cells</td>
</tr>
<tr>
<td><strong> CD41</strong></td>
<td> αβ dimer: α, 125; β, 122 </td> <td> GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa </td> <td> Platelets, megakaryocytes</td> <td> Subunit of platelet fibrinogen receptor, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for von Willebrand factor, fibronectin, and thrombospondin </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD42a,b,c,d</strong></td>
<td bgcolor="#cccccc"> a, 23; <br /> b, 135,23; <br /> c, 22;</td> <td bgcolor="#cccccc"> a, GPIX; b, GPIb-α; c, GPIb-β; d, GPV</td> <td bgcolor="#cccccc"> Platelets, megakaryocytes </td> <td bgcolor="#cccccc"> Adhesion of platelets to endothelium; amplification of platelet response to thrombin </td>
</tr>
<tr>
<td><strong> CD43</strong></td>
<td> 95-115 in <br /> T cells, 115-135 in neutrophils</td> <td> gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin </td> <td> All leukocytes except most resting B cells </td> <td> Possible anti-adhesive ("barrier") molecule mediating repulsion between leukocytes and other cells </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD44</strong></td>
<td bgcolor="#cccccc"> 85</td> <td bgcolor="#cccccc"> ECMR Ⅲ, H-CAM, HUTCH-1, Hermes, Lu, Pgp-1, gp85 </td> <td bgcolor="#cccccc"> Surface of most cell types </td> <td bgcolor="#cccccc"> Adhesion molecule mediating leukocyte attachment and homing to peripheral lymphoid organs and sites of inflammation </td>
</tr>
<tr>
<td><strong> CD44R</strong></td>
<td> 85-250 in epithelial cells; 85-200 in lymphocytes</td> <td> CD44v, CD44v9; heterogenous group of CD44 variant isoforms designated by the variant exons that they include (v2-v10 in humans) </td> <td> Epithelial cells and monocytes (constitutively), activated leukocytes </td> <td> Possible role (particulary for CD44v6) in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD45</strong></td>
<td bgcolor="#cccccc"> 210, 220, 180, 200</td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> </tr> <tr> <td><strong> CD46</strong></td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td bgcolor="#cccccc"> <strong>CD47</strong></td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> </tr> <tr> <td><strong> CD48</strong></td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td bgcolor="#cccccc"><strong> CD49a</strong></td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> </tr> <tr> <td><strong> CD49b</strong></td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td bgcolor="#cccccc"><strong> CD49c</strong></td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> </tr> <tr> <td><strong> CD49d</strong></td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td bgcolor="#cccccc"><strong> CD49e</strong></td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> </td> </tr> <tr> <td><strong> CD49f</strong></td> <td> </td> <td> Leukocyte common antigen (LCA), T200, EC 3.1.3.4;many dofferent isoforms with different molecular weights, e.g..<br /td> <td>B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO </td> <td> </td> </tr> <tr> <td bgcolor="#cccccc"><strong> CD50</strong></td> <td bgcolor="#cccccc"> All hematopoeitic cells;different isoforms characteristic of differentiated subsets of various hematopoeitic cells</td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> Essential role in T-and B-cell antigen-receptor-mediated activation;</td> <td bgcolor="#cccccc">possible role in receptor-mediated activation in other leukocytes </td>
</tr>
</tbody>
</table>
