Difference between revisions of "CD31-45"
From Opengenome.net
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<td> αβ dimer: α, 125; β, 122 </td> | <td> αβ dimer: α, 125; β, 122 </td> | ||
<td> GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa </td> | <td> GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa </td> | ||
| − | <td> </td> | + | <td> Platelets, megakaryocytes</td> |
| − | <td> </td> | + | <td> Subunit of platelet fibrinogen receptor, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for von Willebrand factor, fibronectin, and thrombospondin </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CD42a,b,c,d</strong></td> | <td bgcolor="#cccccc"><strong> CD42a,b,c,d</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> a, 23; <br /> |
| − | <td bgcolor="#cccccc"> </td> | + | b, 135,23; <br /> |
| − | <td bgcolor="#cccccc"> </td> | + | c, 22;</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> a, GPIX; b, GPIb-α; c, GPIb-β; d, GPV</td> |
| + | <td bgcolor="#cccccc"> Platelets, megakaryocytes </td> | ||
| + | <td bgcolor="#cccccc"> Adhesion of platelets to endothelium; amplification of platelet response to thrombin </td> | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
<td><strong> CD43</strong></td> | <td><strong> CD43</strong></td> | ||
| − | <td> </td> | + | <td> 95-115 in <br /> |
| − | <td> </td> | + | T cells, 115-135 in neutrophils</td> |
| − | <td> </td> | + | <td> gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin </td> |
| − | <td> </td> | + | <td> All leukocytes except most resting B cells </td> |
| + | <td> Possible anti-adhesive ("barrier") molecule mediating repulsion between leukocytes and other cells </td> | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
Revision as of 22:58, 5 September 2006
|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD31 | 130-140 | GPiia, endocam, platelet endothelial cell adhesion molecule (PECAM-1) |
Endothelial cells, platelets, monocytes, neutrophils, NK cells, subsets of T cells | Adhesion molecule |
| CD32 | 40 | FCRⅡ, FcγRⅡ | B cells, granulocytes, monocytes | Receptor for Fc portion of antigen-antibody-complexed IgG molecules |
| CD33 | 67 | gp67, p67 | Monocytes, myeloid precursors | Sialic acid-dependent cytoadhesion molecule, a sialoadhesion |
| CD34 | 40 (based on amino seq.) | gp105-120 | Early lymphohematopoeitic stem and progenitor cells, small-vessel endothelial cells, embryonic fibroblasts, some cells in fetal and adult nervous tissue | Cell-cell adhesion molecule |
| CD35 | Many forms: 160, 190, 220, 250, 165, 195, 225, 255 | C3bR, C4bR, complement receptor type one (CR1), immune adherence receptor | Erythrocytes, neutrophils, monocytes, eosinophils, B cells | Receptor for C4b/C3b particles, mediating their adherence and phagocytosis; facilitator of C3b and C4b cleavage, thus limiting complement activation |
| CD36 | 88-113 (platelet form) | GPⅢb, GPIV, OKM5-antigen, PASIV | Platelets, mature monocytes / macrophages, endothelial cells | Adhesion molecule in platelet adhesion and aggregation, and in platelet-monocyte or platelet-tumor cell interaction; molecule for recognition of apoptotic neutrophils; scavenger receptor for oxidized LDL |
| CD37 | 40-52 | gp52-50 | B cells; low levels on T cells, neutrophils, granulocytes, and monocytes | Role in signal transduction |
| CD38 | 45 | T10 | Early-stage B and T cells, germinal-center B cells, plasma cells | NAD glycohydrolase |
| CD39 | 40-52 | Bp50 | B cells, T cells, neutrophils, granulocytes, monocytes | Role in signal transduction |
| CD40 | 48 (monomer) | Bp50 | B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors | Roles in B-cell growth, differentiation, and isotype-switching; apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of adhesion molecules on dendritic cells |
| CD41 | αβ dimer: α, 125; β, 122 | GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa | Platelets, megakaryocytes | Subunit of platelet fibrinogen receptor, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for von Willebrand factor, fibronectin, and thrombospondin |
| CD42a,b,c,d | a, 23; b, 135,23;c, 22; |
a, GPIX; b, GPIb-α; c, GPIb-β; d, GPV | Platelets, megakaryocytes | Adhesion of platelets to endothelium; amplification of platelet response to thrombin |
| CD43 | 95-115 in T cells, 115-135 in neutrophils |
gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin | All leukocytes except most resting B cells | Possible anti-adhesive ("barrier") molecule mediating repulsion between leukocytes and other cells |
| CD44 | ||||
| CD44R | ||||
| CD45 |
