CD121-135

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD121a	80	IL-1R, IL-1R type 1, type 1 IL-1R	Thymocytes, T cells	Type Ⅰ interleukin-1 receptor
CDw121b	60-70	Il-1R type2, type2 IL-1R	B cells, macrophages, monocytes	Type Ⅰ interleukin-1 receptor
CD122	70-75	Interleukin-2 receptor β chain (IL-2Rβ)	T cells, B cells, NK cells, monocytes/macrophages	Critical component of IL-2-and IL-15-mediated signaling
CD123	70	IL-3 receptor α subunit (IL-3Rα)	Bone-marrow stem cells, granulocytes, monocytes, megakaryocytes	IL-3 receptor chain
CD124	140	IL-4R	Hematopoeitiv and non-hematopoeitic cells	Receptor subunit of IL-4 and IL-113
CDw125	60	IL-5Rα	Eosinophils, activated B cells, basophils	Low-affinity receptor for IL-5; α chain of IL-5 receptor
CD126	80	Interleukin-6 receptor (IL-6R); associates with CD130	T cells, monocytes, activated B cells, hepatocytes and some other non-hematopoeitic cells	Receptor for IL-6
CD127	65-75, 90	IL-7 receptor(IL-7R), IL-7 receptor α (IL-7Rα) p90 I17R	B-cell precursors, T cells	Specific receptor for interleukin 7
CDw128a	58-67	CXCR1, interleukin-8 receptor A (IL-8RA)	Not known	Chemokine receptor
CDw128b	58-67	CXCR2, interleukin-8 receptor B (IL-8RB)	Not known	Chemokine receptor
CD130	~130-140	gp130	Low level on almost all cell types	Receptor subunit required for signal transduction when interleukin 6, interleukin11, leukemia inhibitory factor, ciliary neutrophic factor, oncostatin M, and cardiotrophin-1 bind to their receptors
CDw131	120-140	Common beta subunit	Most myeloid cells including early progenitors, early B cells	Receptor subunit required for signal transduction by IL-3, GM-CSF, and IL-5 receptors
CD132	64, 65-70	Common cytokine receptor γ chain, common γ chain	T cells, B cells, NK cells, monocytes/macrophages, neutrophils	Subunit of IL-2, IL-4, IL-7, IL-9, and IL-15 receptors
CD134	50	OX40	Activated T cellls	Possible adhesion molecule co-stimulator
CD135	130	FMS-like tyrosine kinase 3(flt3), Flk-2 in mice, STK-1	Multipotential, myelomonocytic, and primitive B-cell progenitors	Growth factor receptor for early hematopoeitic progenitors