0
edits
Changes
no edit summary
<tr>
<td bgcolor="#cccccc"><strong> CD49c</strong></td>
<td bgcolor="#cccccc"> 88-113 (platelet form)125, 30 </td> <td bgcolor="#cccccc"> GPⅢbα-3 integrin chain, GPIV, OKM5VLA-antigen, PASIV3  alpha; chain</td> <td bgcolor="#cccccc"> Platelets, mature monocytes / macrophagesB cells, endothelial many adherent cells </td> <td bgcolor="#cccccc"> Adhesion molecule in platelet adhesion and aggregationIntegrin that associates with CD29, and in plateletbinds collagen, laminin-monocyte or platelet-tumor cell interaction; molecule for recognition of apoptotic neutrophils; scavenger receptor for oxidized LDL 5, fibronectin, entacin, invasin</td>
</tr>
<tr>
<td><strong> CD49d</strong></td>
<td> 40-52145</td> <td> gp52α-504 integrin chain, VLA-4 α chain</td> <td> Many cell types, including T cells, B cells; low levels on T , monocytes, eosinophils, basophils, mast cells, neutrophilsthymocytes, granulocytesNK cells, and monocytes dendritic cells;not on neutrophils</td> <td> Role in signal transductionCell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4 beta;1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing;co-stimulatory molecule for T-cell activation</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD49e</strong></td>
<td bgcolor="#cccccc"> 45135</td> <td bgcolor="#cccccc"> T10 alpha;-5 integrin chain, FNR α chain, VLA-5 α chain</td> <td bgcolor="#cccccc"> Early-stage B and Many cell types, including memory T cells, germinal-center B cellsmonocytes, plasma cells platelets</td> <td bgcolor="#cccccc"> NAD glycohydrolase Integrin that associates with CD29, binds fibronectin, invasin</td>
</tr>
<tr>
<td><strong> CD49f</strong></td>
<td> 40-52125, 25</td> <td> Bp50 alpha;-6 integrinchain, platelet gpI, VLA-6 αchain</td> <td> B T cells, T cellsmonocytes, neutrophilsplatelets, granulocytesmegakaryocytes, monocytes trophoblasts</td> <td> Role in signal transduction Integrin that associates with CD29, binds laminin, invasin, merosine</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD50</strong></td>
<td bgcolor="#cccccc"> 48 (monomer)130</td> <td bgcolor="#cccccc"> Bp50 Intercellular molecule-3, ICAM-3</td> <td bgcolor="#cccccc"> B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors Leukocytes of all lineages</td> <td bgcolor="#cccccc"> Roles Co-stimulatory molecule in Bimmune response; regulator of LFA-cell growth, differentiation, 1/ICAM-1 and isotypeintegrin-switchingβ apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of dependent adhesion molecules on dendritic cells</td>
</tr>
<tr>
<td><strong> CD51</strong></td>
<td> αβ dimer: α, 125; β, 122 </td> <td> GlycoproteinⅡb (GPⅡb) VNR-αⅡbchain,  alpha;V integrin chain, vitronsctin receptor; forms platelet fibrinogen receptor α-V integrin by association with GP ⅢaCD61 </td> <td> Platelets, megakaryocytes</td> <td> Subunit of platelet fibrinogen receptorα-V integrin, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and thrombospondin probably apoptotic cells</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD52</strong></td>
<td bgcolor="#cccccc"> a, 23; <br /> b, 135,23; <br /> c, 22;25-29</td> <td bgcolor="#cccccc"> a, GPIX; b, GPIbCAMPATH-α; c1, GPIb-β; d, GPVHE5</td> <td bgcolor="#cccccc"> PlateletsThymocytes, lymphocytes, monocytes, megakaryocytes macrophages, epithelial cells lining male reproductive tract</td> <td bgcolor="#cccccc"> Adhesion of platelets to endothelium; amplification of platelet response to thrombin Not known</td>
</tr>
<tr>
<td><strong> CD53</strong></td>
<td> 9532-115 in <br /> T cells, 115-135 in neutrophils42</td> <td> gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin MRC OX44</td> <td> All leukocytes except most resting B cells Leukocytes </td> <td> Possible anti-adhesive ("Signal transduction;barrier") molecule mediating repulsion between leukocytes and other crosslinking promotes activation of human B cells </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD54</strong></td>
<td bgcolor="#cccccc"> 8590, 75-115</td> <td bgcolor="#cccccc"> ECMR Ⅲ, H-CAM, HUTCHIntercellular adhesion molecule-1, Hermes, Lu, Pgp(ICAM-1, gp85 )</td> <td bgcolor="#cccccc"> Surface of most cell types Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells</td> <td bgcolor="#cccccc"> Adhesion molecule mediating leukocyte attachment Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and homing to peripheral lymphoid organs and sites of inflammation for RBCs infected with malarial parasites</td>
</tr>
<tr>
<td><strong> CD55</strong></td>
<td> 85-250 in epithelial cells; 85-200 in lymphocytes70, 55</td> <td> CD44v, CD44v9; heterogenous group of CD44 variant isoforms designated by the variant exons that they include Decay accelerating factor (v2-v10 in humansDAF) </td> <td> Epithelial Most cells and monocytes (constitutively), activated leukocytes </td> <td> Possible role (particulary for CD44v6) in leukocyte attachment to Protective barrier against inappropriate complement activation and rolling deposition on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation plasma membranes</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD56</strong></td>
<td bgcolor="#cccccc"> 210, 175-220, 180, 200</td> <td bgcolor="#cccccc"> Leukocyte common antigen Leu-19, NKH1, neural cell adhesion molecule (LCANCAM), T200, EC 3.1.3.4; many dofferent isoforms with different molecular weights, e.g..<br /> B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO </td> <td bgcolor="#cccccc"> All hematopoeitic cells; different isoforms characteristic Human NK cellls, a subset of differentiated subsets of various hematopoeitic CD4+ and CD8+ T cells</td> <td bgcolor="#cccccc"> Essential role in T-and B-cell antigen-receptor-mediated activation; possible role in receptor-mediated activation in other leukocytes Not known for the immune system;adhesion molecule for cells of the nervous system</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD57</strong></td> <td bgcolor="#cccccc"> </td> <td bgcolor="#cccccc"> HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins </td> <td bgcolor="#cccccc"> NK cells; subsets of T cells, B cells, and monocytes </td> <td bgcolor="#cccccc"> Not known </td>
</tr>
<tr>
<td bgcolor="#cccccc"> <strong>CD58</strong></td>
<td bgcolor="#cccccc"> 55-70</td> <td bgcolor="#cccccc"> Lymphocyte function-associated antigen 3 (LFA-3) </td> <td bgcolor="#cccccc"> Many hematopoeitic and non-hematopoeitic celltypes </td> <td bgcolor="#cccccc"> Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells </td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CD59</strong></td> <td bgcolor="#cccccc"> 18-25</td> <td bgcolor="#cccccc"> IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin </td> <td bgcolor="#cccccc"> Many hematopoeitic and non-hematopoeitic celltypes </td> <td bgcolor="#cccccc"> Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion</td>
</tr>
<tr>
<td bgcolor="#cccccc"><strong> CDw60</strong></td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> 9-O-acetyl-GD3; carbohydrate modification found on some gangliosides</td> <td bgcolor="#cccccc"> Subset of T cells, platelets, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes </td> <td bgcolor="#cccccc"> Possible contributor to co-stimulatory/comitogenic signals for T cells </td>
</tr>
</tbody>
</table>