EPO Signaling Pathway
From Opengenome.net
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_epoPathway.gif
|
SHC |
GRB2 |
|
SHC |
EpoR |
|
FOS |
TRE |
|
FOS |
C-JUN |
|
FOS |
AP-1 |
|
FOS |
DNA double helix |
|
FOS |
ELK-1 |
|
JAK2 |
EPO R |
|
JAK2 |
STAT5 |
|
JAK2 |
EPOR-EPO Complex |
|
RAF1 |
MEK |
|
RAF1 |
RAS-GTP Complex |
|
JUN |
CK-Ⅱ |
|
JUN |
AP-1 |
|
SOS-1 |
SOS-1-GRB2-SHC Complex |
|
SOS-1 |
GTP->GDP |
|
STAT5A |
JAK2 |
|
STAT5A |
EPO R-EPO Complex |
|
STAT5A |
STAT5-STAT5 Complex |
|
STAT5A |
PIE |
|
STAT5A |
DNA double helix |
|
ELK-1 |
ERK |
|
ELK-1 |
C-FOS |
|
EPO R |
EPO |
|
EPO R |
PLC r |
|
EPO R |
STAT5 |
|
EPO R |
JAK2 |
|
EPO R |
SHP-1 |
|
EPO R |
SHC-GRB2-SOS-1 Complex |
|
|
TRANSCRIPTION FACTOR
= FOS, C-JUN, ELK-1, STAT5
