CD61-75

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Revision as of 17:59, 7 September 2006 by Ihjung (talk | contribs)

 CD antigen

 MW.(kDa) 

 Synonyms & Properties

 Leukocyte expression  

 Function

 CD61  110  CD61A, GPⅡb/Ⅲa, β3 integrin chain  Platelets, megakaryocytes, macrophages  Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)
 CD62E  140  E-selectin, ELAM-1, LECAM-2   Acutely activated endothelium, chronic inflammatory lesions of skin and synovium   Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites
 CD62L  65  L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1  Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes  Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites
 CD62P  120  P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)  Endothelium, platelets, megakaryocytes  Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation
 CD63  40-60   LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA)  Platelets, endothelium, degranulated neutrophils, monocytes, macrophages endothelium  Not known
 CD64  72  Fcγ\RI, FCRI  Monocytes, macrophages, bood and germinal-center dendritic cells, PMN activated by IFN-γ or G-CSF, early myeloid-lineage cells  Phagocytosis: receptor-mediated endocytosis of IgG-antigen complexes; antigen capture for presentation to T cells; antibody-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediates
 CD65        
 CD65s        
 CD66a        
 CD66b        
 CD66c        
 CD66d        
 CD66e        
 CD66f        
 CD68        
 CD69        
 CD70        
 CD71         
 CD72         
 CD73        
 CD74        
 CDw75