CD61-75

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD61	110	CD61A, GPⅡb/Ⅲa, β3 integrin chain	Platelets, megakaryocytes, macrophages	Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)
CD62E	140	E-selectin, ELAM-1, LECAM-2	Acutely activated endothelium, chronic inflammatory lesions of skin and synovium	Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites
CD62L	65	L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1	Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes	Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites
CD62P	120	P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)	Endothelium, platelets, megakaryocytes	Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation
CD63	160	α-2 integrin chain, GPIa VLA-2 α chain	B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts	Integrin that associates with CD29, binds collagen, laminin-1
CD64	125, 30	α-3 integrin chain, VLA-3 α chain	B cells, many adherent cells	Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin
CD65	145	α-4 integrin chain, VLA-4 α chain	Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils	Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4β1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation
CD65s	135	α-5 integrin chain, FNR α chain, VLA-5 α chain	Many cell types, including memory T cells, monocytes, platelets	Integrin that associates with CD29, binds fibronectin, invasin
CD66a	125, 25	α-6 integrinchain, platelet gpI, VLA-6 α chain	T cells, monocytes, platelets, megakaryocytes, trophoblasts	Integrin that associates with CD29, binds laminin, invasin, merosine
CD66b	130	Intercellular molecule-3, ICAM-3	Leukocytes of all lineages	Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-β-dependent adhesion
CD66c	125	VNR-α chain, α V integrin chain, vitronsctin receptor; forms α-V integrin by association with CD61	Platelets, megakaryocytes	Subunit of α-V integrin, which binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and probably apoptotic cells
CD66d	25-29	CAMPATH-1, HE5	Thymocytes, lymphocytes, monocytes, macrophages, epithelial cells lining male reproductive tract	Not known
CD66e	32-42	MRC OX44	Leukocytes	Signal transduction; crosslinking promotes activation of human B cells
CD66f	90, 75-115	Intercellular adhesion molecule-1 (ICAM-1)	Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells	Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and for RBCs infected with malarial parasites
CD68	70, 55	Decay accelerating factor (DAF)	Most cells	Protective barrier against inappropriate complement activation and deposition on plasma membranes
CD69	175-220	Leu-19, NKH1, neural cell adhesion molecule (NCAM)	Human NK cellls, a subset of CD4+ and CD8+ T cells	Not known for the immune system; adhesion molecule for cells of the nervous system
CD70		HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins	NK cells; subsets of T cells, B cells, and monocytes	Not known
CD71	55-70	Lymphocyte function-associated antigen 3 (LFA-3)	Many hematopoeitic and non-hematopoeitic celltypes	Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells
CD72	18-25	IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin	Many hematopoeitic and non-hematopoeitic celltypes	Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion
CD73		9-O-acetyl-GD3; carbohydrate modification found on some gangliosides	Subset of T cells, platelets, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes	Possible contributor to co-stimulatory/comitogenic signals for T cells
CD74
CDw75