CBL mediated ligand-induced downregulation of EGF receptor

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http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_cblPathway.gif 

   

EGF

EGF R

EGF R

EGF

EGF R

PKC

EGF R

Grb2

EGF R

Ub

GRB2

CBL

GRB2

END

GRB2

EGF R

PKC

EGF R

CBL

Grb2

CBL

END
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