Apoptotic DNA fragmentation and tissue homeostasis
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_DNAfragmentPathway.gif
Pathway Interaction
|
BAX |
BID |
|
|
BCL-2 |
|
|
BCL-XL |
|
|
p53 |
|
BAD |
AKT pathway |
|
AKT |
BAD |
|
|
Pro-CASPASE |
|
APAF-1 |
Cytochrome C |
|
|
pro-caspase 9 |
|
BCL2 |
BCL-KL |
|
|
BAX |
|
TLN |
PAXILLIN |
|
|
PKC |
|
|
EIF2a |
|
EIF2a |
STAT1 |
|
|
Capases |
|
ATM |
p53 |
|
CASP3 |
pro-caspase3 |
|
|
caspase6 |
|
CASP7 |
FAK, PKC 등의 Modified signaling |
|
CYCS |
ADAF-1 |
|
|
Pro-caspase 9 |
|
STAT1 |
PAXILLIN |
|
|
EIF2a |
|
|
PARP |
|
PARP |
CASPASES |
|
|
STAT1 |