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CD16-30

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<table style="WIDTH: 740px; HEIGHT: 348px" cellspacing="1" cellpadding="1" width="740" summary="" border="1">
<tbody>
<tr>
<td bgcolor="#999999">
 CD antigen
</td>
<td bgcolor="#999999">
 MW.(kDa)  
</td>
<td bgcolor="#999999">
 Synonyms & Properties
</td>
<td bgcolor="#999999">
 Leukocyte expression  
</td>
<td bgcolor="#999999">
 Function
</td>
</tr>
<tr>
<td> CD16</td>
<td> 50-80</td>
<td> FCγRⅢA</td>
<td> Macrophage, NK cells, neutrophils</td>
<td> subunit of low-affinity Fc receptor, involved in phagocytosis of antibody-complexed antien and in antibody-dependent cell-mediated cytotosicity (ADCC)</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CDw17</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> Lactosylceramide (LacCer); carbohydrate antigen</td>
<td bgcolor="#cccccc"> Monocytes, granulocytes, basophils, platelets, subset of peripheral B cells (CD19+), tonsillar dendritic cells</td>
<td bgcolor="#cccccc"> Not known; ability to bind bacteria for possible role in phagocytosis</td>
</tr>
<tr>
<td> CD18</td>
<td> </td>
<td> T3; composed of 3 polypeptide chains: γ, δ, ε</td>
<td> Thmocytes, T cells, NK1-T cells</td>
<td> Essential role in TCR signal transduction and in cell-surface expression of the TCR</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD19</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> L3T4</td>
<td bgcolor="#cccccc"> MHC class Ⅱ-restricted T cells, some thymocytes, monocytes/macrophage, granulocytes </td>
<td bgcolor="#cccccc"> Co-receptor for MHC class Ⅱ-restricted T-cell activation; thymic differentiation marker for T cells; receptor for HIV</td>
</tr>
<tr>
<td> CD20</td>
<td> </td>
<td> Leu1, T1, Ly-1</td>
<td> Mature T cells, early thymocytes; small amounts on a subset of mature B cells (B1a B cells) </td>
<td> Positive or negative modulation of TCR and BCR signaling, depending on the type and developmental stage of cell displaying it</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD21</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> T12 </td>
<td bgcolor="#cccccc"> Most peripheral T cells, thumocytes, a subset of B cells </td>
<td bgcolor="#cccccc"> Adhesion molecule that binds developing thymocytes to thymic epitheral cells; possible co-stimulatory molecule for mature T cells </td>
</tr>
<tr>
<td> CD22</td>
<td> </td>
<td> gp-40 </td>
<td> Pluripotent hematopoetic cells, T cells, thymocytes </td>
<td> Not known </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD23</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> T8, Leu-22 ; a membrane-bound dimer of two chains; αβ heterodimer or αα homodimer</td>
<td bgcolor="#cccccc"> MHC class Ⅰ-restricted T cells, some thymocytes</td>
<td bgcolor="#cccccc"> Coreceptor for MHC class Ⅰ-restricted T cells </td>
</tr>
<tr>
<td> CD24</td>
<td> </td>
<td> MRP-1, p24 </td>
<td> Platelets, early B cells, activated B cells, activated T cells, eosinophils, basophils </td>
<td> Modulation of cell adhesion and migration; trigger of platelet activation </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD25</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> Common acute lymphoblastic leukemia antigen (CALLA), EC 3.4.24.11 (neprilysin), enkephalinase, gp100, neutral endopeptidase (NEP), metalloendopeptidase </td>
<td bgcolor="#cccccc"> B-cell precursors, T-cell precursors, bone-marrow stromalcells </td>
<td bgcolor="#cccccc"> Protease</td>
</tr>
<tr>
<td> CD26</td>
<td> </td>
<td> α-L integrin chain, LFA-1 α (leukocyte function-associated molecule-1 α) chain; forms LFA-1 by association with CD18</td>
<td> Monocytes, ,acrophages, granulocytes, lymphocytes </td>
<td> Subunit of LFA-1. a membrane glycoprotein that provides cell-cell adhesion by interaction with ICAM-1 (intercellular adhesion molecule-1)  </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD11b</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> C3biR, CR3; α chain of MAC-1 integrin; forms MAC-1 by association with CD18</td>
<td bgcolor="#cccccc"> Granulocytes, monocytes, NK cells, subset of T cells, subsets of B cells </td>
<td bgcolor="#cccccc"> Subunit of MAC-1, which mediates interactions og neutrophils and monocytes with stimulated endothelium, phagocytosis of particles coated with iC3b or IgG, spreading or chemotaxis of leukocytes; ligand-binding molecule that binds C3b, ICAM-1 (CD54), ICAM-2 (CD102), and fibrinogen</td>
</tr>
<tr>
<td> CD27</td>
<td> </td>
<td> α-X integrin chain,  αxβ2, α chain of integrin CR4, leukocte surface antigen, p150, 95 ; forms CR by association with CD18</td>
<td> Monocytes, macrophage, NK cells, granulocytes, subset of T cell, subset of B cells </td>
<td> Subunit of complex with CD18 that is similar to CD 11b/CD18 complex, with which it acts cooperatively; the major form of CD11/CD18 on tissue macrophage</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD28</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> Monocytes, granulocytes, platelets</td>
<td bgcolor="#cccccc"> Not known</td>
</tr>
<tr>
<td> CD29</td>
<td> </td>
<td> Aminopeptidase N (APN), EC 3.4.11.2, gp150</td>
<td> Early progenitors of granulocytes and monocytes (CFU-GM), mature granulocytes and monocytes, bone-marrow stromal cells, osteoclasts, a small number of lasrge granular lymphocytes</td>
<td> Not known</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD30</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> LPS receptor (LPS-R)</td>
<td bgcolor="#cccccc"> Monocytes, macrophages, granulocytes (weak expression)</td>
<td bgcolor="#cccccc"> Receptor for endotoxin (lipopolysaccharide [LPS]), activating monocytes or neutrophils to release cytokines (TNF) and up-regulate adhesion molecules when LPS is bound </td>
</tr>
</tbody>
</table>

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CD16-30

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