<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_srcRPTPPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_srcRPTPPathway.gif</a><br /><br />Cell cycle을 통한 progression은 proto-ancogene C-Src의 활성화에 의해서 수행되는 protein tyrosine kinase이다.<br />Src의 overexproession은 multiple protein substrates의 tyrosine phosphorylation과 세포의 transformation을 가지고 온다.<br /><br />Pathway Interaction<br /><table style="WIDTH: 486px; HEIGHT: 163px" cellspacing="1" cellpadding="1" width="486" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">CDC2</p> </td> <td> <p align="center">Cyclin B</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">SRC</p> </td> </tr> <tr> <td> <p align="center">GRB2</p> </td> <td> <p align="center">RPTPa</p> </td> </tr> <tr> <td> <p align="center">PKC</p> </td> <td> <p align="center">RPTPa</p> </td> </tr> <tr> <td> <p align="center">CSK</p> </td> <td> <p align="center">SRC</p> </td> </tr> <tr> <td> <p align="center">SRC</p> </td> <td> <p align="center">RPTPa</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">CSK</p> </td> </tr> </tbody></table>