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<h2 class="insight" minmax_bound="true">Insight: Stem Cells</h2>
<p class="volume" minmax_bound="true"><abbr title="volume" minmax_bound="true">Vol</abbr>Vol. 441, <abbr title="Number" minmax_bound="true">No</abbr>No. 7097 <abbr title="pages" minmax_bound="true">pp</abbr>pp1059-1102</p>
<img alt="Stem-cell Biology" src="http://www.nature.com/nature/supplements/insights/stem_cells/images/cover.jpg" minmax_bound="true" />
<p class="norm" minmax_bound="true">In recent years, stem cells have been the subject of considerable excitement. Great progress has been made in understanding their mechanisms and unravelling their potential for therapeutic application. Widespread use of stem-cell-based therapies is still a long way off, but could one day benefit vast numbers of patients, including those with cancer, neurodegenerative disorders and heart disease. </p>
<p class="norm" minmax_bound="true">This <span class="journalname" minmax_bound="true">Nature</span> Insight is accompanied by a special stem cells <a href="http://www.nature.com/podcast/stemcells/index.html" minmax_bound="true">podcast</a>, which features interviews with leading stem-cell researchers and a live discussion on the various scientific and ethical problems in this exciting field. </p>
<p class="norm" minmax_bound="true">Readers are invited to join an <a href="http://blogs.nature.com/nature/insightstemcells/" minmax_bound="true">web forum</a> to exchange views and opinions raised by the <span class="journalname" minmax_bound="true">Insight</span> articles. There is also a <a href="http://blogs.nature.com/news/blog/podcasts/" minmax_bound="true">podcast forum</a> for issues discussed in the stem cells podcast. </p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Stem-cell Biology</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Natalie DeWitt</p>
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<p class="links" minmax_bound="true"><a class="abstract" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/abs/4411059a.html" minmax_bound="true">Abstract</a> |<a class="fulltext" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/full/4411059a.html" minmax_bound="true">Full Text</a> | <a title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/pdf/4411059a.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (164<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">A glossary for stem-cell biology</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Austin Smith</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04954</p>
<p class="links" minmax_bound="true"><a class="abstract" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04954.html" minmax_bound="true">Abstract</a> |<a class="fulltext" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04954.html" minmax_bound="true">Full Text</a> | <a title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04954.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (68<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Nuclear reprogramming and pluripotency</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Konrad Hochedlinger and Rudolf Jaenisch</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04955</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Nuclear reprogramming and pluripotency" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04955.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Nuclear reprogramming and pluripotency" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04955.html" minmax_bound="true">Full Text</a> | <a title="Nuclear reprogramming and pluripotency" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04955.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (644<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Asymmetric and symmetric stem-cell divisions in development and cancer</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Sean J. Morrison and Judith Kimble</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04956</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Asymmetric and symmetric stem-cell divisions in development and cancer" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04956.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Asymmetric and symmetric stem-cell divisions in development and cancer" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04956.html" minmax_bound="true">Full Text</a> | <a title="Asymmetric and symmetric stem-cell divisions in development and cancer" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04956.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (473<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">The stem-cell niche as an entity of action</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">David T. Scadden</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04957</p>
<p class="links" minmax_bound="true"><a class="abstract" title="The stem-cell niche as an entity of action" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04957.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="The stem-cell niche as an entity of action" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04957.html" minmax_bound="true">Full Text</a> | <a title="The stem-cell niche as an entity of action" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04957.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (323 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Stem cells, ageing and the quest for immortality</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Thomas A. Rando</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04958</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells, ageing and the quest for immortality" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04958.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells, ageing and the quest for immortality" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04958.html" minmax_bound="true">Full Text</a> | <a title="Stem cells, ageing and the quest for immortality" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04958.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (641 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Generation of neuronal variability and complexity</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Alysson R. Muotri and Fred H. Gage</p>
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<p class="links" minmax_bound="true"><a class="abstract" title="Generation of neuronal variability and complexity" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04959.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Generation of neuronal variability and complexity" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04959.html" minmax_bound="true">Full Text</a> | <a title="Generation of neuronal variability and complexity" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04959.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (756 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<p class="abs" minmax_bound="true">Olle Lindvall and Zaal Kokaia</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04960</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04960.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04960.html" minmax_bound="true">Full Text</a> | <a title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04960.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (402<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<p class="abs" minmax_bound="true">Deepak Srivastava and Kathryn N. Ivey</p>
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<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04961.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04961.html" minmax_bound="true">Full Text</a> | <a title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04961.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (345 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<p class="abs" minmax_bound="true">Claudio Bordignon</p>
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<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04962.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04962.html" minmax_bound="true">Full Text</a> | <a title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04962.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (323 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<p class="volume" minmax_bound="true"><abbr title="volume" minmax_bound="true">Vol</abbr>Vol. 441, <abbr title="Number" minmax_bound="true">No</abbr>No. 7097 <abbr title="pages" minmax_bound="true">pp</abbr>pp1059-1102</p>
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<p class="norm" minmax_bound="true">In recent years, stem cells have been the subject of considerable excitement. Great progress has been made in understanding their mechanisms and unravelling their potential for therapeutic application. Widespread use of stem-cell-based therapies is still a long way off, but could one day benefit vast numbers of patients, including those with cancer, neurodegenerative disorders and heart disease. </p>
<p class="norm" minmax_bound="true">This <span class="journalname" minmax_bound="true">Nature</span> Insight is accompanied by a special stem cells <a href="http://www.nature.com/podcast/stemcells/index.html" minmax_bound="true">podcast</a>, which features interviews with leading stem-cell researchers and a live discussion on the various scientific and ethical problems in this exciting field. </p>
<p class="norm" minmax_bound="true">Readers are invited to join an <a href="http://blogs.nature.com/nature/insightstemcells/" minmax_bound="true">web forum</a> to exchange views and opinions raised by the <span class="journalname" minmax_bound="true">Insight</span> articles. There is also a <a href="http://blogs.nature.com/news/blog/podcasts/" minmax_bound="true">podcast forum</a> for issues discussed in the stem cells podcast. </p>
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<p class="abs" minmax_bound="true">Natalie DeWitt</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/4411059a</p>
<p class="links" minmax_bound="true"><a class="abstract" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/abs/4411059a.html" minmax_bound="true">Abstract</a> |<a class="fulltext" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/full/4411059a.html" minmax_bound="true">Full Text</a> | <a title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/pdf/4411059a.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (164<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h3 class="page" id="glossary" minmax_bound="true">Glossary</h3>
<h4 minmax_bound="true"><span class="atl" minmax_bound="true">A glossary for stem-cell biology</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Austin Smith</p>
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<p class="links" minmax_bound="true"><a class="abstract" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04954.html" minmax_bound="true">Abstract</a> |<a class="fulltext" title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04954.html" minmax_bound="true">Full Text</a> | <a title="A glossary for stem-cell biology" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04954.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (68<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Nuclear reprogramming and pluripotency</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Konrad Hochedlinger and Rudolf Jaenisch</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04955</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Nuclear reprogramming and pluripotency" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04955.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Nuclear reprogramming and pluripotency" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04955.html" minmax_bound="true">Full Text</a> | <a title="Nuclear reprogramming and pluripotency" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04955.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (644<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Asymmetric and symmetric stem-cell divisions in development and cancer</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Sean J. Morrison and Judith Kimble</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04956</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Asymmetric and symmetric stem-cell divisions in development and cancer" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04956.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Asymmetric and symmetric stem-cell divisions in development and cancer" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04956.html" minmax_bound="true">Full Text</a> | <a title="Asymmetric and symmetric stem-cell divisions in development and cancer" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04956.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (473<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">The stem-cell niche as an entity of action</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">David T. Scadden</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04957</p>
<p class="links" minmax_bound="true"><a class="abstract" title="The stem-cell niche as an entity of action" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04957.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="The stem-cell niche as an entity of action" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04957.html" minmax_bound="true">Full Text</a> | <a title="The stem-cell niche as an entity of action" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04957.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (323 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Stem cells, ageing and the quest for immortality</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Thomas A. Rando</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04958</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells, ageing and the quest for immortality" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04958.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells, ageing and the quest for immortality" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04958.html" minmax_bound="true">Full Text</a> | <a title="Stem cells, ageing and the quest for immortality" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04958.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (641 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Generation of neuronal variability and complexity</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Alysson R. Muotri and Fred H. Gage</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04959</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Generation of neuronal variability and complexity" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04959.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Generation of neuronal variability and complexity" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04959.html" minmax_bound="true">Full Text</a> | <a title="Generation of neuronal variability and complexity" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04959.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (756 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Stem cells for the treatment of neurological disorders</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Olle Lindvall and Zaal Kokaia</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04960</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04960.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04960.html" minmax_bound="true">Full Text</a> | <a title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04960.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (402<abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Potential of stem-cell-based therapies for heart disease</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Deepak Srivastava and Kathryn N. Ivey</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04961</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04961.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04961.html" minmax_bound="true">Full Text</a> | <a title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04961.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (345 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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<h4 minmax_bound="true"><span class="atl" minmax_bound="true">Stem-cell therapies for blood diseases</span><span class="free-access" minmax_bound="true"> Free access</span></h4>
<p class="abs" minmax_bound="true">Claudio Bordignon</p>
<p class="doi" minmax_bound="true"><abbr title="digital object identifier" minmax_bound="true">doi</abbr>doi:10.1038/nature04962</p>
<p class="links" minmax_bound="true"><a class="abstract" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/abs/nature04962.html" minmax_bound="true">Abstract</a> | <a class="fulltext" title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/full/nature04962.html" minmax_bound="true">Full Text</a> | <a title="Stem cells for the treatment of neurological disorders" href="http://www.nature.com/nature/journal/v441/n7097/pdf/nature04962.pdf" minmax_bound="true"><abbr title="portable document format" minmax_bound="true">PDF</abbr>PDF (323 <abbr title="kilobytes" minmax_bound="true">KB</abbr>KB)</a></p>
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