Cell Cycle : G2/M Check point
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g2Pathway.gif
|
ATM |
ATR |
|
ATM |
DNA repair |
|
ATM |
BRCA1 |
|
ATR |
ATM |
|
ATR |
BRCA1 |
|
ATR |
CHK2 |
|
ATR |
p53 |
|
ATR |
CHK1 |
|
BRCA1 |
DNA repair |
|
BRCA1 |
ATR-ATM complex |
|
CDC2 |
Cyclin B |
|
CDC2 |
GADD45 |
|
CDC2 |
p21 |
|
CDC2 |
CDC25 |
|
CDC2 |
PLK1 |
|
CDC2 |
MYT1 |
|
CDC2 |
WEE1 |
|
CHEK2 |
p53 |
|
CHEK2 |
ATM-ATR complex |
|
CHEK2 |
CDC25 |
|
CHEK1 |
CHK2 |
|
TP53 |
MDM2 |
|
TP53 |
DNA-PK |
|
TP53 |
ATM-ATR complex |
|
TP53 |
CHK2 |
|
TP53 |
MDM2-p19 complex |
|
GP300 |
p53 |
|
GADD45A |
CDC2 |
|
GADD45A |
p53 |
|
MDM2 |
p53 |
|
MDM2 |
p19 |
|
WEE1 |
CDC2-Cyclin B complex |
|
WEE1 |
CDC34 |
|
PLK1 |
CDC25 |
|
PLK1 |
MYT1 |
|
MYT1 |
PLK1 |
|
MYT1 |
p90RSK |
|
MYT1 |
CDC2-Cyclin B complex |
|
PLK1 |
CDC2-cyclin B complex |
|
|
Transcription factor
-BRCA1, p53,