CD46-60
|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD46 | 52-58, 35-40 | Membrane cofactor protein (MCP) |
Peripheral-blood lymphocytes (PBL), non-hematopoeitic tissues such as salivary glands and kidney ducts | Protective barrier against inappropriate complement activation and deposition on plasma membranes |
| CD47 | 45-60, 47-55 | RH-associated protein, gp42, integrin-associated protein(IAP), neutrophilin, ovarian carcinoma antigen3 (OA3) | Most cells | Adhesion molecule; thrombospondin receptor |
| CD48 | 45 | BCM1 in mouse, Blast-1, Hu Lym3, OX-45 in rat | All leukocytes except neutrophils | Adhesion molecule via its receptor, CD2 |
| CD49a | 200 | α-1 integrin chain, very late antigen α 1 chain (VLA-1 α chain) | Activated T cells, monocytes, neuronal cells, smooth muscles | Integrin that associates with CD29, binds collagen, laminin-1 |
| CD49b | 160 | α-2 integrin chain, GPIa VLA-2 α chain | B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts | Integrin that associates with CD29, binds collagen, laminin-1 |
| CD49c | 125, 30 | α-3 integrin chain, VLA-3 α chain | B cells, many adherent cells | Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin |
| CD49d | 145 | α-4 integrin chain, VLA-4 α chain | Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils | Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4β1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation |
| CD49e | 135 | α-5 integrin chain, FNR α chain, VLA-5 α chain | Many cell types, including memory T cells, monocytes, platelets | Integrin that associates with CD29, binds fibronectin, invasin |
| CD49f | 125, 25 | α-6 integrinchain, platelet gpI, VLA-6 α chain | T cells, monocytes, platelets, megakaryocytes, trophoblasts | Integrin that associates with CD29, binds laminin, invasin, merosine |
| CD50 | 130 | Intercellular molecule-3, ICAM-3 | Leukocytes of all lineages | Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-β-dependent adhesion |
| CD51 | 125 | VNR-α chain, α V integrin chain, vitronsctin receptor; forms α-V integrin by association with CD61 | Platelets, megakaryocytes | Subunit of α-V integrin, which binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and probably apoptotic cells |
| CD52 | 25-29 | CAMPATH-1, HE5 | Thymocytes, lymphocytes, monocytes, macrophages, epithelial cells lining male reproductive tract | Not known |
| CD53 | 32-42 | MRC OX44 | Leukocytes | Signal transduction; crosslinking promotes activation of human B cells |
| CD54 | 90, 75-115 | Intercellular adhesion molecule-1 (ICAM-1) | Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells | Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and for RBCs infected with malarial parasites |
| CD55 | 70, 55 | Decay accelerating factor (DAF) | Most cells | Protective barrier against inappropriate complement activation and deposition on plasma membranes |
| CD56 | 175-220 | Leu-19, NKH1, neural cell adhesion molecule (NCAM) | Human NK cellls, a subset of CD4+ and CD8+ T cells | Not known for the immune system; adhesion molecule for cells of the nervous system |
| CD57 | HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins | NK cells; subsets of T cells, B cells, and monocytes | Not known | |
| CD58 | 55-70 | Lymphocyte function-associated antigen 3 (LFA-3) | Many hematopoeitic and non-hematopoeitic celltypes | Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells |
| CD59 | 18-25 | IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin | Many hematopoeitic and non-hematopoeitic celltypes | Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion |
| CDw60 | 9-O-acetyl-GD3; carbohydrate modification found on some gangliosides | Subset of T cells, platelets, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes | Possible contributor to co-stimulatory/comitogenic signals for T cells |