CBL mediated ligand-induced downregulation of EGF receptor
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_cblPathway.gif
EGF |
EGF R |
EGF R |
EGF |
EGF R |
PKC |
EGF R |
Grb2 |
EGF R |
Ub |
GRB2 |
CBL |
GRB2 |
END |
GRB2 |
EGF R |
PKC |
EGF R |
CBL |
Grb2 |
CBL |
END |