<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_arapPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_arapPathway.gif</a><br /><br />Ah receptor, bHLH/PAS transcription factor, 2,3,7,8-tetrachlorodibenzo-P-dioxin과 같은 agonist의 upon binding은 핵 안으로 옮겨지고, transcription factor인 ARNT와 함께 heterodimerizes인 Ahreceptor/ARNT 상태로 존재하게 된다. 이 heterodimer는 dioxin-responsive elements를 binding 하고 CYP1A1, CYP 1A2, CYP 1B1, NAD(P)H quinone oxidoreductase와 같은 다른 element들과 상호작용을 한다.<br /><br />Pathway Interaction<br /><table style="WIDTH: 643px; HEIGHT: 168px" cellspacing="1" cellpadding="1" width="643" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">ARFGAP</p> </td> <td> <p align="center">GEFs</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PLD</p> </td> </tr> <tr> <td> <p align="center">ARF1</p> </td> <td> <p align="center">GTP</p> </td> </tr> <tr> <td> <p align="center">ARFGAP1<br />ARFGAP3<br />DDEF1<br />DDEF2</p> </td> <td> <p align="center">ARF1-GTP</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Coat protein</p> </td> </tr> </tbody></table>