Erk1/Erk2 Mapk Signaling Pathway
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_erkPathway.gif
|
PTPRR |
ERK2 |
|
PTPRR |
PP2A |
|
SHC |
GRB2 |
|
SHC |
NGFR |
|
SHC |
SRC |
|
MNK2 |
MNK1 |
|
MNK2 |
ERK1-ERK2 Complex |
|
STAT3 |
ERK2-ERK1 Complex |
|
SRC |
GBr |
|
SRC |
SHC |
|
RAF1 |
RAS |
|
RAF1 |
MEK1-MEK2 Complex |
|
ELK1 |
ERK1-ERK2 Complex |
|
SOS1 |
GTP |
|
SOS1 |
GRB2 |
|
MYC |
MYC |
|
MYC |
ERK1-ERK2 Complex |
|
NGF |
NGFR |
|
NGFR |
NGF |
|
NGFR |
SHC |
|
GRB2 |
SOS-1 |
|
GRB2 |
SHC |
|
MNK1 |
MNK2 |
|
MNK1 |
ERK1-ERK2 Complex |
TRANSCRIPTION FACTOR
=STAT3, ELK1