Cell Cycle : G1/S Check point
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif
|
SMAD3 |
SMAD4 |
|
SMAD3 |
TGFb |
|
ATM |
ATR |
|
ATM |
p53 |
|
RB |
ABL |
|
RB |
HDAC |
|
RB |
E2F-1 |
|
CDK2 |
Cyclind-CDK4-CDK6 |
|
CDK4 |
CDK6 |
|
CDK4 |
Cyclin D |
|
SKP2 |
p21 ubiquitination |
|
HDAC |
RB |
|
TGBF1 |
SMAD3-SMAD4 complex |
|
TGBF1 |
E2F-1 |
|
CDC25A |
CDK2-Cyclin E complex |
|
CDC25A |
CDK6-CDK4-Cyclin D complex |
|
GSK3B |
Growth Factor with drawal |
|
Cyclin D |
CDK4-CDK6 complex |
|
TP53 |
ATM-ATR complex |
|
TP53 |
p21 |
|
TFDP1 |
E2F-1 |
|
ART |
ATM |
|
ART |
p53 |
Transcription factor
-TP53, TFDP1, E2F-1, RB