Caspase Cascade in Apoptosis
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_caspasePathway.gif
|
CASPASE4 |
CASP1 |
|
CASPASE8 |
CASP3 |
|
CASP10 |
GRANZYME B |
|
CASP10 |
CASP3 |
|
CASP6 |
CASP3 |
|
CASP6 |
LAMIN B1-LAMINA-LAMIN B2 complex |
|
CASP2 |
LAMINA-LAMIN B2 complex |
|
GZMB |
CASP10 |
|
GZMB |
CASP3 |
|
GZMB |
CASP7 |
|
GZMB |
PERFORIN |
|
CASP3 |
CASP8 |
|
CASP3 |
CASP1 |
|
CASP3 |
CASP6 |
|
CASP3 |
SREBP |
|
CASP3 |
AP-24 |
|
CASP3 |
D4-GDI |
|
CASP3 |
ICRD-CAD |
|
LMNA |
LMN B1 |
|
LMNA |
LMN B2 |
|
GASP7 |
GRANZYME B |
|
GASP7 |
CASP9 |
|
GASP7 |
XIAP-CLAP1-clAP |
|
APRF-1 |
Cytochrome c |
|
APRF-a |
CASP 9 |
|
CASP9 |
CASP7 |
|
CASP9 |
XIAP-clAP1-clAP |
|
PRF |
GRANZYME B |
|
PARP |
CASP 3 |
|
CYCS |
Apaf-1 |
|
LMNB1 |
CASP6 |
|
LMNB2 |
LAMINA |
|
CAD |
ICAD |
|
CAD |
DNA Fragmentation |
Transcription factor
-CAD