|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD61 | 110 | CD61A, GPⅡb/Ⅲa, β3 integrin chain | Platelets, megakaryocytes, macrophages | Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor) |
| CD62E | 140 | E-selectin, ELAM-1, LECAM-2 | Acutely activated endothelium, chronic inflammatory lesions of skin and synovium | Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites |
| CD62L | 65 | L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1 | Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes | Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites |
| CD62P | 120 | P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM) | Endothelium, platelets, megakaryocytes | Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation |
| CD63 | 40-60 | LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA) | Platelets, endothelium, degranulated neutrophils, monocytes, macrophages endothelium | Not known |
| CD64 | 72 | Fcγ\RI, FCRI | Monocytes, macrophages, bood and germinal-center dendritic cells, PMN activated by IFN-γ or G-CSF, early myeloid-lineage cells | Phagocytosis: receptor-mediated endocytosis of IgG-antigen complexes; antigen capture for presentation to T cells; antibody-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediates |
| CD65 | Ceramide-dodecasaccharide, VIM-2; glycolipid | Myeloid cells | Not known | |
| CD65s | Sialylated-CD65, VIM-2; carbohydrate | Granulocytes, monocytes | Possible involvement with phagocytosis and Ca 2+ influx | |
| CD66a | 160-180 | NCA-160, biliary glycoprotein (BGP) | Granulocytes, epithelial cells | Adhesion molecule; receptor for Neisseria gonorrheae and N. meningitidis; trigger of neutrophil activation |
| CD66b | 95-100 | CD67, CGM6, NCA-95 | Granulocytes | Adhesion molecule; trigger of neutrophil activation |
| CD66c | 90 | NCA, NCA-50/90 | Granulocytes, epithelial cells | Adhesion molecule; trigger of neutrophil activation |
| CD66d | 30 | CGM1 | Granulocytes | Unclear; receptor for Neisseria gonorrheae and N. meningitidis |
| CD66e | 180-200 | Carcinoembryonic antigen (CEA) | Epithelial cells | Unclear; possible adhesion molecule |
| CD66f | 54-72 | Pregnancy-specific b1 glycoprotein, SP-1, pregnancy-specific glycoprotein (PSG) | Fetal liver; produced in placenta and released | Unclear; possible involvement in immune regulation and protection of fetus from maternal immune system; necessary for successful pregnancy |
| CD68 | 110 | gp110, macrosialin | Monocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells, myeloid progenitor cells, subset of CD34+ hematopoeitic progenitor cells, activated T cells, some peropheral-blood B cells | Not known |
| CD69 | 60 | Activation-inducer molecule (AIM), EA1, MLR3, gp34/28, very early activation (VEA) | Activated leukocytes, inducing T cells, thymocytes, B cells, NK cells, neutrophils, eosinophils, and Langerhans cells; subset of mature thymocytes, germinal-center mantle B cells, some CD4+ germinal-center T cells | Involvement in early events of lymphocyte, monocyte, and platelet activation: promotes Ca2+ influx, synthesis of cytokines and their receptors, induction of c-myc and c-fos proto-oncogene expression; role in promoting lysis mediated by activated NK cells |
| CD70 | 75, 95, 170 | CD27-ligand, Ki24 antigen | Activated T and B cells and macrophages | Ligand for CD27; possible role in co-stimulation of B and T cells |
| CD71 | 190 | T9, transferrin receptor | All proliferating cells | Iron uptake: binds ferrotransferrin at neutral pH and internalizes complex to acidic endosomal compartment, where tron is released |
| CD72 | 42 | Ly-19.2, Ly-32.2, Lyb-2 | B cells (except plasma cells) | Not known |
| CD73 | 69, 70, 72 | Ecto-5', nucleotidase | Subpopulations of T and B cells, many peripheral-blood B cells, follicular dendritic cells, epithelial cells, endothelial cells | Dephosphorylation of purine and pyrimidine ribo-and deoxyribonucleoside monophosphates to their corresponding nucleosides |
| CD74 | 33, 35, 41 | Class Ⅱ-specific chaperone, Li, invariant chain | B cells, activated T cells, macrophages, activated endothelial and epithelial cells | Intracellular sorting of MHC class Ⅱ molecules |
| CDw75 | B cells, Subpopulation of peripheral-blood T cells, erythrocytes | Cell adhesion; ligand for CD22 |