|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD16 | 50-80 | FCγRⅢA | Macrophage, NK cells, neutrophils | Subunit of low-affinity Fc receptor, involved in phagocytosis of antibody-complexed antien and in antibody-dependent cell-mediated cytotosicity (ADCC) |
| CDw17 | Lactosylceramide (LacCer); carbohydrate antigen | Monocytes, granulocytes, basophils, platelets, subset of peripheral B cells (CD19+), tonsillar dendritic cells | Not known; ability to bind bacteria for possible role in phagocytosis | |
| CD18 | 95 | β2 integrin chain; β subunit that combines with CD11a, CD11b, or CD11c subunit to form integrins | All leukocytes | Adhesion and signaling in the hematopoietic system (see entries for CD11a, CD11b, and CD11c) |
| CD19 | >120 | B4 | Follicular dendritic cells, B cells from earliest recognizable B-lineage cells during development to B-cell blasts but lost on maturation to plasma cells | Part of B-cell coreceptor with CD21 and CD81; a critical signal transduction molecule that regulates B-cell development, activation, and differentiation |
| CD20 | 33 | B1, Bp35 | B cells | Not known |
| CD21 | 145 (membrane form) 130 (soluble form) |
C3d receptor, CR2, Epstein Barr virus receptor (EBV-R) | B cells, follicular dendritic cells, subset of immature thymocytes | Receptor for EBV, C3d, C3dg, and iC3b; with CD19 and CD81, part of the B-cell coreceptor, a large signal-transduction complex |
| CD22 | 140 | BL-CAM, Lyb8 in mouse | Surface of mature B cells, cytoplasm of late pro-and early pre-B cells | Adhesion molecule; signaling molecule |
| CD23 | 45 | B6, BLAST-2, FcεRⅡ, Leu-20 ; low-affinity IgE receptor | Human B cells, monocytes follicular dendritic cells | Regulation of IgE synthesis; trigger to release TNF, IL-1, IL-6, and GM-CSF from human monocytes |
| CD24 | 35-45 | BA-1, heat-stable antigen (HSA) in mouse | B-cell lineage but lost at plasma-cell stage, mature granulocytes | Not known |
| CD25 | 55 | IL-2 receptor α chain, IL-2R, Tac antogen | PHA-stimulated T cells; anti-IGM-stimulated B cells, LPS-stimulated monocytes/macrophages | α subunit of receptor for cytokine IL-2 |
| CD26 | 110, 120 | EC 3.4.14.5, adenosine deaminase-binding protein (ADA-binding protein), dipeptidylpeptidase Ⅳ (DPV Ⅳ ectoenzyme) | Mature of activated T cells, B cells, NK cells, macrophages | Co-stimulatory molecule in T-cell activation |
| CD27 | 55 | SI52, T14 | Mature thymocytes, activated T cells and B cells, NK cells, macrophages, most peropheral T cells, memory-type B cells | Mediation of a co-stimulatory signal for T- and B-cell activation; role in murine T-cell development |
| CD28 | 90 (homodimeric form) | T44, Tp44 | Matur CD3+ thymocytes, most peripheral T cells, plasma cells | Co-stimulation of T-cell proliferation and cytokine production upon binding CD80 or CD86 |
| CD29 | 130 | β1 integrin chain, GP, platelet GPⅡa, VLA-β chain | Leukocytes | β subunit of VLA-1 integrin |
| CD30 | 120 | Ber-H2 antigen, Ki-1 antigen | Activated T cells, activated B cells, activated NK cells, monocytes | Stimulation of proliferation or induction of cell death, depending upon conditions and cell type expressing it |