|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD16 | 50-80 | FCγRⅢA | Macrophage, NK cells, neutrophils | Subunit of low-affinity Fc receptor, involved in phagocytosis of antibody-complexed antien and in antibody-dependent cell-mediated cytotosicity (ADCC) |
| CDw17 | Lactosylceramide (LacCer); carbohydrate antigen | Monocytes, granulocytes, basophils, platelets, subset of peripheral B cells (CD19+), tonsillar dendritic cells | Not known; ability to bind bacteria for possible role in phagocytosis | |
| CD18 | T3; composed of 3 polypeptide chains: γ, δ, ε | Thmocytes, T cells, NK1-T cells | Essential role in TCR signal transduction and in cell-surface expression of the TCR | |
| CD19 | L3T4 | MHC class Ⅱ-restricted T cells, some thymocytes, monocytes/macrophage, granulocytes | Co-receptor for MHC class Ⅱ-restricted T-cell activation; thymic differentiation marker for T cells; receptor for HIV | |
| CD20 | Leu1, T1, Ly-1 | Mature T cells, early thymocytes; small amounts on a subset of mature B cells (B1a B cells) | Positive or negative modulation of TCR and BCR signaling, depending on the type and developmental stage of cell displaying it | |
| CD21 | T12 | Most peripheral T cells, thumocytes, a subset of B cells | Adhesion molecule that binds developing thymocytes to thymic epitheral cells; possible co-stimulatory molecule for mature T cells | |
| CD22 | gp-40 | Pluripotent hematopoetic cells, T cells, thymocytes | Not known | |
| CD23 | T8, Leu-22 ; a membrane-bound dimer of two chains; αβ heterodimer or αα homodimer | MHC class Ⅰ-restricted T cells, some thymocytes | Coreceptor for MHC class Ⅰ-restricted T cells | |
| CD24 | MRP-1, p24 | Platelets, early B cells, activated B cells, activated T cells, eosinophils, basophils | Modulation of cell adhesion and migration; trigger of platelet activation | |
| CD25 | Common acute lymphoblastic leukemia antigen (CALLA), EC 3.4.24.11 (neprilysin), enkephalinase, gp100, neutral endopeptidase (NEP), metalloendopeptidase | B-cell precursors, T-cell precursors, bone-marrow stromalcells | Protease | |
| CD26 | α-L integrin chain, LFA-1 α (leukocyte function-associated molecule-1 α) chain; forms LFA-1 by association with CD18 | Monocytes, ,acrophages, granulocytes, lymphocytes | Subunit of LFA-1. a membrane glycoprotein that provides cell-cell adhesion by interaction with ICAM-1 (intercellular adhesion molecule-1) | |
| CD11b | C3biR, CR3; α chain of MAC-1 integrin; forms MAC-1 by association with CD18 | Granulocytes, monocytes, NK cells, subset of T cells, subsets of B cells | Subunit of MAC-1, which mediates interactions og neutrophils and monocytes with stimulated endothelium, phagocytosis of particles coated with iC3b or IgG, spreading or chemotaxis of leukocytes; ligand-binding molecule that binds C3b, ICAM-1 (CD54), ICAM-2 (CD102), and fibrinogen | |
| CD27 | α-X integrin chain, αxβ2, α chain of integrin CR4, leukocte surface antigen, p150, 95 ; forms CR by association with CD18 | Monocytes, macrophage, NK cells, granulocytes, subset of T cell, subset of B cells | Subunit of complex with CD18 that is similar to CD 11b/CD18 complex, with which it acts cooperatively; the major form of CD11/CD18 on tissue macrophage | |
| CD28 | Monocytes, granulocytes, platelets | Not known | ||
| CD29 | Aminopeptidase N (APN), EC 3.4.11.2, gp150 | Early progenitors of granulocytes and monocytes (CFU-GM), mature granulocytes and monocytes, bone-marrow stromal cells, osteoclasts, a small number of lasrge granular lymphocytes | Not known | |
| CD30 | LPS receptor (LPS-R) | Monocytes, macrophages, granulocytes (weak expression) | Receptor for endotoxin (lipopolysaccharide [LPS]), activating monocytes or neutrophils to release cytokines (TNF) and up-regulate adhesion molecules when LPS is bound |