CDC Regulation of DNA Replication

From Opengenome.net

http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_mcmPathway.gif 

   

ORC4L

CDC6

ORC4L

CDT1

ORC4L

Mcm2-7

CDC6

CDT1

CDC6

ORC

CDC6

Mcm2-7

CDC6

Cyclin E

CDK2

p27

CDK2

Cyclin E

CDT1

CDC6

CDT1

ORC

CCNE1

CDK2

CCNE1

p27

CCNE1

CDC6

CCNE1

CDT1

MCM5

CDC6

MCM5

ORC

MCM5

SCF