CD46-60

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD46	52-58, 35-40	Membrane cofactor protein (MCP)	Peripheral-blood lymphocytes (PBL), non-hematopoeitic tissues such as salivary glands and kidney ducts	Protective barrier against inappropriate complement activation and deposition on plasma membranes
CD47	45-60, 47-55	RH-associated protein, gp42, integrin-associated protein(IAP), neutrophilin, ovarian carcinoma antigen3 (OA3)	Most cells	Adhesion molecule; thrombospondin receptor
CD48	45	BCM1 in mouse, Blast-1, Hu Lym3, OX-45 in rat	All leukocytes except neutrophils	Adhesion molecule via its receptor, CD2
CD49a	200	α-1 integrin chain, very late antigen α 1 chain (VLA-1 α chain)	Activated T cells, monocytes, neuronal cells, smooth muscles	Integrin that associates with CD29, binds collagen, laminin-1
CD49b	160	α-2 integrin chain, GPIa VLA-2 α chain	B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts	Integrin that associates with CD29, binds collagen, laminin-1
CD49c	125, 30	α-3 integrin chain, VLA-3 α chain	B cells, many adherent cells	Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin
CD49d	145	α-4 integrin chain, VLA-4 α chain	Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils	Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4β1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation
CD49e	135	α-5 integrin chain, FNR α chain, VLA-5 α chain	Many cell types, including memory T cells, monocytes, platelets	Integrin that associates with CD29, binds fibronectin, invasin
CD49f	125, 25	α-6 integrinchain, platelet gpI, VLA-6 α chain	T cells, monocytes, platelets, megakaryocytes, trophoblasts	Integrin that associates with CD29, binds laminin, invasin, merosine
CD50	130	Intercellular molecule-3, ICAM-3	Leukocytes of all lineages	Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-β-dependent adhesion
CD51	125	VNR-α chain, α V integrin chain, vitronsctin receptor; forms α-V integrin by association with CD61	Platelets, megakaryocytes	Subunit of α-V integrin, which binds vitronsctin, von Willebrand factor, fibronectin, thrombospondin, and probably apoptotic cells
CD52	25-29	CAMPATH-1, HE5	Thymocytes, lymphocytes, monocytes, macrophages, epithelial cells lining male reproductive tract	Not known
CD53	32-42	MRC OX44	Leukocytes	Signal transduction; crosslinking promotes activation of human B cells
CD54	90, 75-115	Intercellular adhesion molecule-1 (ICAM-1)	Activated endothelial cells, activated T cells, activated B cells, monocytes, endothelial cells	Ligand for CD11a/CD18 or CD11b/CD18; receptor for rhinoviruses and for RBCs infected with malarial parasites
CD55	70, 55	Decay accelerating factor (DAF)	Most cells	Protective barrier against inappropriate complement activation and deposition on plasma membranes
CD56	175-220	Leu-19, NKH1, neural cell adhesion molecule (NCAM)	Human NK cellls, a subset of CD4+ and CD8+ T cells	Not known for the immune system; adhesion molecule for cells of the nervous system
CD57		HNK-1, Leu-7; a carbohydrate antigen (oligosaccharide), component of many glycoproteins	NK cells; subsets of T cells, B cells, and monocytes	Not known
CD58	55-70	Lymphocyte function-associated antigen 3 (LFA-3)	Many hematopoeitic and non-hematopoeitic celltypes	Adhesion between killer T cells and target eclls, antigen-presenting cells and T cells, or thymocytes and thymic epithelial cells
CD59	18-25	IF-5Ag, H19, HRF20, MACIF, MIRL, P-18 protectin	Many hematopoeitic and non-hematopoeitic celltypes	Inhibitor for mrmbrane attack complex (MAC) assembly, thus protecting cells from complement mediated lysis; signaling role (as a GPI-anchored molecule) in T-cell activation; possible role in cell adhesion
CDw60		9-O-acetyl-GD3; carbohydrate modification found on some gangliosides	Subset of T cells, platelets, thymic epithelium, activated keratinocytes, synovial fibroblasts, glomeruli, smooth muscle cells, astrocytes	Possible contributor to co-stimulatory/comitogenic signals for T cells