CD76-90

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 CD antigen

 MW.(kDa) 

 Synonyms & Properties

 Leukocyte expression  

 Function

 CDw76  110  CD61A, GPⅡb/Ⅲa, β3 integrin chain  Platelets, megakaryocytes, macrophages  Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)
 CD77  140  E-selectin, ELAM-1, LECAM-2   Acutely activated endothelium, chronic inflammatory lesions of skin and synovium   Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites
 CD79a  65  L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1  Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes  Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites
 CD79b  120  P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)  Endothelium, platelets, megakaryocytes  Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation
 CD80  40-60   LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA)  Platelets, endothelium, degranulated neutrophils, monocytes, macrophages endothelium  Not known
 CD81  72  Fcγ\RI, FCRI  Monocytes, macrophages, bood and germinal-center dendritic cells, PMN activated by IFN-γ or G-CSF, early myeloid-lineage cells  Phagocytosis: receptor-mediated endocytosis of IgG-antigen complexes; antigen capture for presentation to T cells; antibody-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediates
 CD82    Ceramide-dodecasaccharide, VIM-2; glycolipid   Myeloid cells   Not known 
 CD83    Sialylated-CD65, VIM-2; carbohydrate   Granulocytes, monocytes  Possible involvement with phagocytosis and Ca 2+ influx 
 CD84  160-180  NCA-160, biliary glycoprotein (BGP)   Granulocytes, epithelial cells  Adhesion molecule; receptor for Neisseria gonorrheae and N. meningitidis; trigger of neutrophil activation 
 CD85  95-100  CD67, CGM6, NCA-95   Granulocytes  Adhesion molecule; trigger of neutrophil activation 
 CD86  90  NCA, NCA-50/90   Granulocytes, epithelial cells   Adhesion molecule; trigger of neutrophil activation 
 CD87  30  CGM1   Granulocytes  Unclear; receptor for Neisseria gonorrheae and N. meningitidis
 CD88  180-200  Carcinoembryonic antigen (CEA)   Epithelial cells  Unclear; possible adhesion molecule 
 CD89  54-72  Pregnancy-specific b1 glycoprotein, SP-1, pregnancy-specific glycoprotein (PSG)   Fetal liver; produced in placenta and released   Unclear; possible involvement in immune regulation and protection of fetus from maternal immune system; necessary for successful pregnancy 
 CD90  110  gp110, macrosialin   Monocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells, myeloid progenitor cells, subset of CD34+ hematopoeitic progenitor cells, activated T cells, some peropheral-blood B cells   Not known