CD16-30

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD16	50-80	FCγRⅢA	Macrophage, NK cells, neutrophils	subunit of low-affinity Fc receptor, involved in phagocytosis of antibody-complexed antien and in antibody-dependent cell-mediated cytotosicity (ADCC)
CDw17		Lactosylceramide (LacCer); carbohydrate antigen	Monocytes, granulocytes, basophils, platelets, subset of peripheral B cells (CD19+), tonsillar dendritic cells	Not known; ability to bind bacteria for possible role in phagocytosis
CD18		T3; composed of 3 polypeptide chains: γ, δ, ε	Thmocytes, T cells, NK1-T cells	Essential role in TCR signal transduction and in cell-surface expression of the TCR
CD19		L3T4	MHC class Ⅱ-restricted T cells, some thymocytes, monocytes/macrophage, granulocytes	Co-receptor for MHC class Ⅱ-restricted T-cell activation; thymic differentiation marker for T cells; receptor for HIV
CD20		Leu1, T1, Ly-1	Mature T cells, early thymocytes; small amounts on a subset of mature B cells (B1a B cells)	Positive or negative modulation of TCR and BCR signaling, depending on the type and developmental stage of cell displaying it
CD21		T12	Most peripheral T cells, thumocytes, a subset of B cells	Adhesion molecule that binds developing thymocytes to thymic epitheral cells; possible co-stimulatory molecule for mature T cells
CD22		gp-40	Pluripotent hematopoetic cells, T cells, thymocytes	Not known
CD23		T8, Leu-22 ; a membrane-bound dimer of two chains; αβ heterodimer or αα homodimer	MHC class Ⅰ-restricted T cells, some thymocytes	Coreceptor for MHC class Ⅰ-restricted T cells
CD24		MRP-1, p24	Platelets, early B cells, activated B cells, activated T cells, eosinophils, basophils	Modulation of cell adhesion and migration; trigger of platelet activation
CD25		Common acute lymphoblastic leukemia antigen (CALLA), EC 3.4.24.11 (neprilysin), enkephalinase, gp100, neutral endopeptidase (NEP), metalloendopeptidase	B-cell precursors, T-cell precursors, bone-marrow stromalcells	Protease
CD26		α-L integrin chain, LFA-1 α (leukocyte function-associated molecule-1 α) chain; forms LFA-1 by association with CD18	Monocytes, ,acrophages, granulocytes, lymphocytes	Subunit of LFA-1. a membrane glycoprotein that provides cell-cell adhesion by interaction with ICAM-1 (intercellular adhesion molecule-1)
CD11b		C3biR, CR3; α chain of MAC-1 integrin; forms MAC-1 by association with CD18	Granulocytes, monocytes, NK cells, subset of T cells, subsets of B cells	Subunit of MAC-1, which mediates interactions og neutrophils and monocytes with stimulated endothelium, phagocytosis of particles coated with iC3b or IgG, spreading or chemotaxis of leukocytes; ligand-binding molecule that binds C3b, ICAM-1 (CD54), ICAM-2 (CD102), and fibrinogen
CD27		α-X integrin chain,  αxβ2, α chain of integrin CR4, leukocte surface antigen, p150, 95 ; forms CR by association with CD18	Monocytes, macrophage, NK cells, granulocytes, subset of T cell, subset of B cells	Subunit of complex with CD18 that is similar to CD 11b/CD18 complex, with which it acts cooperatively; the major form of CD11/CD18 on tissue macrophage
CD28			Monocytes, granulocytes, platelets	Not known
CD29		Aminopeptidase N (APN), EC 3.4.11.2, gp150	Early progenitors of granulocytes and monocytes (CFU-GM), mature granulocytes and monocytes, bone-marrow stromal cells, osteoclasts, a small number of lasrge granular lymphocytes	Not known
CD30		LPS receptor (LPS-R)	Monocytes, macrophages, granulocytes (weak expression)	Receptor for endotoxin (lipopolysaccharide [LPS]), activating monocytes or neutrophils to release cytokines (TNF) and up-regulate adhesion molecules when LPS is bound