Ahr signal Transduction Pathway

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http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_acrPathway.gif

Ah receptor, bHLH/PAS transcription factor는 transcription factor인 ARNT와 함께 핵에서 heterodimerizes인 2,3,7,8-tetracholrodibenzo-p-dioxin 형태로 운반되는 길항근의 결합 형태이다.
Ah receptor/ARNT heterodimer는 dioxin-responsive elements와 결합하고, 유전자를 포함하는 여러개의 발현을 억제한다.

Pathway Interaction

   

AHR

HSP90

 

XAP2

 

ARNT

HSP90

Ligand(TCDD)

 

AHR

 

XAP2