Difference between revisions of "DHEA"

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Dehydroepiandrosterone is a steroid hormone, a chemical cousin of testosterone and estrogen.<br /><br />Study reported in 2006 in <span title="Clinical endocrinology.">Clin Endocrinol.&nbsp;</span>shows that short-term treatment with DHEA increased platelet cGMP production, a marker of NO production, in healthy elderly subjects. This effect is coupled with a decrease in PAI-1 and LDL cholesterol levels as well as an increase in testosterone and E(2) levels. These findings, therefore, suggest that chronic DHEA supplementation would exert antiatherogenic effects, particularly in elderly subjects who display low circulating levels of this hormone.<br /><br />Studies have shown that DHEA inhibits carcinogenesis in mammary gland and prostate as well as other organs, a process that is not hormone dependent (2006)<br /><br />Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality. (2006)<br /><br />[http://whyfiles.org/051fat_fixes/dhea.html Whyfiles]<br />[http://www.pubmed.org Pubmed] | [[Vitamin]] | [[디에이치이에이]]&nbsp;<br />[http://ligandome.org Ligandome]<br />
+
Dehydroepiandrosterone is a steroid hormone, a chemical cousin of testosterone and estrogen.<br />
 +
<br />
 +
Study reported in 2006 in <span title="Clinical endocrinology.">Clin Endocrinol.&nbsp;</span>shows that short-term treatment with DHEA increased platelet cGMP production, a marker of NO production, in healthy elderly subjects. This effect is coupled with a decrease in PAI-1 and LDL cholesterol levels as well as an increase in testosterone and E(2) levels. These findings, therefore, suggest that chronic DHEA supplementation would exert antiatherogenic effects, particularly in elderly subjects who display low circulating levels of this hormone.<br />
 +
<br />
 +
Studies have shown that DHEA inhibits carcinogenesis in mammary gland and prostate as well as other organs, a process that is not hormone dependent (2006)<br />
 +
<br />
 +
Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality. (2006)<br />
 +
<br />
 +
<p><strong>Dehydroepiandrosterone</strong> (<strong>DHEA</strong>), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism)]. DHEA is the precursor of androstenedione, testosterone and estrogen. It is the most abundant hormone in the human body.</p>
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<script type="text/javascript">
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//<![CDATA[
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if (window.showTocToggle) { var tocShowText = "show"; var tocHideText = "hide"; showTocToggle(); }
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//]]>
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</script>
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<p>&nbsp;</p>
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<h2><span class="mw-headline">Synonyms and brand names</span></h2>
 +
<p>Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3&beta;-Hydroxy-5-androsten-17-one; 3&beta;-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.</p>
 +
<p>Brand names for DHEA include Prastera&reg; and Fidelin&reg;.</p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">DHEAS (Dehydroepiandrosterone sulfate)</span></h2>
 +
<p><strong>Dehydroepiandrosterone sulfate</strong> (<strong>DHEAS</strong>, PubChem 12594) is the sulfated version of DHEA, - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. While DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation.</p>
 +
<p>From a practical point measurement of DHEAS is preferable to DHEA as levels are more stable.</p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">Production</span></h2>
 +
<div class="thumb tright">
 +
<div class="thumbinner" style="WIDTH: 302px"><img class="thumbimage" height="121" alt="Production of DHEA from Cholesterol" src="http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/300px-DHEA1.svg.png" width="300" longdesc="/wiki/Image:DHEA1.svg" />
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<div class="thumbcaption">
 +
<div class="magnify" style="FLOAT: right"><img height="11" alt="" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" width="15" /></div>
 +
Production of DHEA from Cholesterol</div>
 +
</div>
 +
</div>
 +
<p>DHEA is produced from cholesterol through two cytochrome P450 enzymes. Cholesterol is converted to pregnenolone by the enzyme P450 scc (side chain cleavage) and then another enzyme CYP17A1 converts pregnenolone to 17&alpha;-Hydroxypregnenolone and then to DHEA. In humans DHEA is the dominant steroid hormone and precursor of all sex steroids. Humans produce DHEA in greater quantity than any other species. Even non-human primates have not much more than 10% the relative serum level of DHEA seen in humans. The fact that rodents produce so little DHEA makes the results of experiments conducted with these laboratory animals very controversial.</p>
 +
<p>DHEA production is very high during fetal life by the fetal adrenal glands, declines after birth and remains low during childhood. Production begins around 6 years of age, increasing in quantity until peaking in early adulthood, around the age of 25, and declines afterwards to approximately 10% of peak levels by age 80. It is theorized by some that this decline may be due to reduced oxygen and glucose supply to the adrenal glands as a result of age-related atherosclerosis.</p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">Role</span></h2>
 +
<p>In a simple view DHEA can be understood as a prohormone for the sex steroids. Its DHEAS variation may be looked at as buffer and reservoir. Its production in the brain suggests that it also has a role as a neurosteroid. As most DHEA is produced by the zona reticularis of the adrenal, it is argued that there is a role in the immune and stress response. DHEA may have more biologic roles.</p>
 +
<p>As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.</p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">Effects</span></h2>
 +
<p>Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.<sup class="reference" id="_ref-0">[1]</sup> This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).</p>
 +
<p>Supplementation with DHEA has been shown to decrease insulin resistance.<sup class="reference" id="_ref-1">[2]</sup></p>
 +
<p>Long term supplementation has been shown to improve mood and relieve depression.<sup class="reference" id="_ref-2">[3]</sup></p>
 +
<p>&nbsp;</p>
 +
<h3><span class="mw-headline">Disputed effects</span></h3>
 +
<p>The significance of the hormone in health and disease is not fully established. It is postulated that DHEA supplements are beneficial in alleviating:</p>
 +
<ul>
 +
    <li>cardiovascular disease </li>
 +
    <li>diabetes </li>
 +
    <li>hypercholesterolemia </li>
 +
    <li>obesity </li>
 +
    <li>multiple sclerosis </li>
 +
    <li>Parkinson's disease </li>
 +
    <li>Alzheimer's disease </li>
 +
    <li>disorders of the immune system </li>
 +
    <li>depression </li>
 +
    <li>osteoporosis </li>
 +
    <li>decreased libido </li>
 +
    <li>decreased orgasmic intensity </li>
 +
</ul>
 +
<p>It is also commercially advertised that DHEA:</p>
 +
<ul>
 +
    <li>helps decrease insulin resistance </li>
 +
    <li>improves fat metabolism </li>
 +
    <li>increases immune system function </li>
 +
    <li>has anti-aging properties </li>
 +
    <li>increases lean muscle mass </li>
 +
</ul>
 +
<p>7-Keto&trade; DHEA, a recently identified metabolite of dehydroepiandrosterone (DHEA) is claimed to be both more effective and safer than DHEA because it does not convert itself into testosterone or estrogens in the body.<sup class="noprint Template-Fact"><span title="This claim needs references to reliable sources since February 2007" style="WHITE-SPACE: nowrap">[<em>citation needed</em>]</span></sup></p>
 +
<p>DHEA and DHEAS are readily available in the United States.</p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">Precautions</span></h2>
 +
<p>Some assert that DHEA should not be supplemented outside specialist centres under careful observation of experts in the field of endocrinology.</p>
 +
<p>Side effects may include:</p>
 +
<ul>
 +
    <li>Palpitations and other arrhythmias </li>
 +
    <li>extensive growth of body hair, or hirsutism </li>
 +
    <li>Hair loss, especially male pattern baldness </li>
 +
    <li>acne </li>
 +
</ul>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">Contraindication</span></h2>
 +
<p>As DHEAS and DHEA are converted to sex steroids, their use is contraindicated in patients with any cancer that is estrogen or testosterone dependent.<sup class="noprint Template-Fact"><span title="This claim needs references to reliable sources since February 2007" style="WHITE-SPACE: nowrap">[<em>citation needed</em>]</span></sup></p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">Increasing endogenous production</span></h2>
 +
<p>Regular exercise is known to increase DHEA production in the body.<sup class="reference" id="_ref-3">[4]</sup><sup class="reference" id="_ref-4">[5]</sup><sup class="reference" id="_ref-5">[6]</sup> Caloric restriction has also been shown to increase DHEA in primates.<sup class="reference" id="_ref-6">[7]</sup></p>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">See also</span></h2>
 +
<ul>
 +
    <li>Steroid hormones </li>
 +
    <li>Testosterone </li>
 +
    <li>Estrogen </li>
 +
</ul>
 +
<p>&nbsp;</p>
 +
<h2><span class="mw-headline">References</span></h2>
 +
<ol class="references">
 +
    <li id="_note-0"><strong>^</strong> FDA document regading DHEA and SLE </li>
 +
    <li id="_note-1"><strong>^</strong> Kawano H, Yasue H, Kitagawa A, et al. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab. 2003 Jul;88(7):3190-5. </li>
 +
    <li id="_note-2"><strong>^</strong> Wolkowitz OM, Reus VI, Roberts E, et al. Antidepressant and cognition-enhancing effects of DHEA in major depression. Ann NY Acad Sci. 1995 Dec 29;774:337-9 </li>
 +
    <li id="_note-3"><strong>^</strong> Eur J Appl Physiol Occup Physiol 1998 Oct;78(5):466-71 </li>
 +
    <li id="_note-4"><strong>^</strong> Eur J Appl Physiol. 2001 Jul;85(1- 2):177-84 </li>
 +
    <li id="_note-5"><strong>^</strong> J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):B158-65 </li>
 +
    <li id="_note-6"><strong>^</strong> Exp Gerontol. 2003 Jan-Feb; 38(1-2):35-46 </li>
 +
</ol>
 +
<p><a id="Further_reading" name="Further_reading"></a></p>
 +
<h2><span class="mw-headline">Further reading</span></h2>
 +
<ul>
 +
    <li>Nutrition through the Life Cycle, Judith E. Brown, <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&amp;isbn=0534589863">ISBN 0-534-58986-3</a> </li>
 +
</ul>
 +
<p><a id="External_links" name="External_links"></a></p>
 +
<h2><span class="mw-headline">External links</span></h2>
 +
<ul>
 +
    <li><a class="external text" title="http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm" href="http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm" rel="nofollow"><em>The DHEA Debate: A critical review of experimental data</em></a> at lef.org (Published 2004){This link is to the web equivalent of an infomercial. <strong>Unreliable sponsored analysis</strong>) </li>
 +
    <li><a class="external text" title="http://www.quackwatch.org/01QuackeryRelatedTopics/dhea.html" href="http://www.quackwatch.org/01QuackeryRelatedTopics/dhea.html" rel="nofollow"><em>DHEA: Ignore the Hype</em></a> (Published 1996) at <a title="Quackwatch" href="http://en.wikipedia.org/wiki/Quackwatch">Quackwatch</a> </li>
 +
    <li><a class="external text" title="http://www.benbest.com/nutrceut/DHEA.html" href="http://www.benbest.com/nutrceut/DHEA.html" rel="nofollow">DHEA Hormone Replacement at benbest.com</a> </li>
 +
    <li><a class="external text" title="http://skepdic.com/dhea.html" href="http://skepdic.com/dhea.html" rel="nofollow">What the Skeptic's Dictionary has to say on DHEA</a> </li>
 +
    <li><cite style="FONT-STYLE: normal">Nair K, Rizza R, O'Brien P, Dhatariya K, Short K, Nehra A, Vittone J, Klee G, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall D, Melton L, Smith G, Khosla S, Jensen M (2006). &quot;DHEA in elderly women and DHEA or testosterone in elderly men&quot;. <em>N Engl J Med</em> <strong>355</strong> (16): 1647-59. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889">PMID 17050889</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004%26rft_val_fmt%3Dinfo%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.atitle=DHEA+in+elderly+women+and+DHEA+or+testosterone+in+elderly+men&amp;rft.title=N+Engl+J+Med&amp;rft.jtitle=N+Engl+J+Med&amp;rft.date=2006&amp;rft.volume=355&amp;rft.issue=16&amp;rft.au=Nair+K%2C+Rizza+R%2C+O%27Brien+P%2C+Dhatariya+K%2C+Short+K%2C+Nehra+A%2C+Vittone+J%2C+Klee+G%2C+Basu+A%2C+Basu+R%2C+Cobelli+C%2C+Toffolo+G%2C+Dalla+Man+C%2C+Tindall+D%2C+Melton+L%2C+Smith+G%2C+Khosla+S%2C+Jensen+M&amp;rft.pages=1647-59&amp;rft_id=info:pmid/17050889">&nbsp;</span> <a class="external text" title="http://content.nejm.org/cgi/content/abstract/355/16/1647" href="http://content.nejm.org/cgi/content/abstract/355/16/1647" rel="nofollow">link</a> <br />
 +
    <br />
 +
    [http://whyfiles.org/051fat_fixes/dhea.html Whyfiles]<br />
 +
    [http://www.pubmed.org Pubmed] | [[Vitamin]] | [[디에이치이에이]]&nbsp;<br />
 +
    [http://ligandome.org Ligandome]<br />
 +
    </li>
 +
</ul>

Revision as of 15:14, 22 April 2007

Dehydroepiandrosterone is a steroid hormone, a chemical cousin of testosterone and estrogen.

Study reported in 2006 in Clin Endocrinol. shows that short-term treatment with DHEA increased platelet cGMP production, a marker of NO production, in healthy elderly subjects. This effect is coupled with a decrease in PAI-1 and LDL cholesterol levels as well as an increase in testosterone and E(2) levels. These findings, therefore, suggest that chronic DHEA supplementation would exert antiatherogenic effects, particularly in elderly subjects who display low circulating levels of this hormone.

Studies have shown that DHEA inhibits carcinogenesis in mammary gland and prostate as well as other organs, a process that is not hormone dependent (2006)

Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality. (2006)

Dehydroepiandrosterone (DHEA), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism)]. DHEA is the precursor of androstenedione, testosterone and estrogen. It is the most abundant hormone in the human body.

<script type="text/javascript"> //<![CDATA[ 

if (window.showTocToggle) { var tocShowText = "show"; var tocHideText = "hide"; showTocToggle(); }

//]]> </script>

 

Synonyms and brand names

Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3β-Hydroxy-5-androsten-17-one; 3β-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.

Brand names for DHEA include Prastera® and Fidelin®.

 

DHEAS (Dehydroepiandrosterone sulfate)

Dehydroepiandrosterone sulfate (DHEAS, PubChem 12594) is the sulfated version of DHEA, - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. While DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation.

From a practical point measurement of DHEAS is preferable to DHEA as levels are more stable.

 

Production

Production of DHEA from Cholesterol
Production of DHEA from Cholesterol

DHEA is produced from cholesterol through two cytochrome P450 enzymes. Cholesterol is converted to pregnenolone by the enzyme P450 scc (side chain cleavage) and then another enzyme CYP17A1 converts pregnenolone to 17α-Hydroxypregnenolone and then to DHEA. In humans DHEA is the dominant steroid hormone and precursor of all sex steroids. Humans produce DHEA in greater quantity than any other species. Even non-human primates have not much more than 10% the relative serum level of DHEA seen in humans. The fact that rodents produce so little DHEA makes the results of experiments conducted with these laboratory animals very controversial.

DHEA production is very high during fetal life by the fetal adrenal glands, declines after birth and remains low during childhood. Production begins around 6 years of age, increasing in quantity until peaking in early adulthood, around the age of 25, and declines afterwards to approximately 10% of peak levels by age 80. It is theorized by some that this decline may be due to reduced oxygen and glucose supply to the adrenal glands as a result of age-related atherosclerosis.

 

Role

In a simple view DHEA can be understood as a prohormone for the sex steroids. Its DHEAS variation may be looked at as buffer and reservoir. Its production in the brain suggests that it also has a role as a neurosteroid. As most DHEA is produced by the zona reticularis of the adrenal, it is argued that there is a role in the immune and stress response. DHEA may have more biologic roles.

As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.

 

Effects

Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.[1] This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).

Supplementation with DHEA has been shown to decrease insulin resistance.[2]

Long term supplementation has been shown to improve mood and relieve depression.[3]

 

Disputed effects

The significance of the hormone in health and disease is not fully established. It is postulated that DHEA supplements are beneficial in alleviating:

  • cardiovascular disease
  • diabetes
  • hypercholesterolemia
  • obesity
  • multiple sclerosis
  • Parkinson's disease
  • Alzheimer's disease
  • disorders of the immune system
  • depression
  • osteoporosis
  • decreased libido
  • decreased orgasmic intensity

It is also commercially advertised that DHEA:

  • helps decrease insulin resistance
  • improves fat metabolism
  • increases immune system function
  • has anti-aging properties
  • increases lean muscle mass

7-Keto™ DHEA, a recently identified metabolite of dehydroepiandrosterone (DHEA) is claimed to be both more effective and safer than DHEA because it does not convert itself into testosterone or estrogens in the body.[citation needed]

DHEA and DHEAS are readily available in the United States.

 

Precautions

Some assert that DHEA should not be supplemented outside specialist centres under careful observation of experts in the field of endocrinology.

Side effects may include:

  • Palpitations and other arrhythmias
  • extensive growth of body hair, or hirsutism
  • Hair loss, especially male pattern baldness
  • acne

 

Contraindication

As DHEAS and DHEA are converted to sex steroids, their use is contraindicated in patients with any cancer that is estrogen or testosterone dependent.[citation needed]

 

Increasing endogenous production

Regular exercise is known to increase DHEA production in the body.[4][5][6] Caloric restriction has also been shown to increase DHEA in primates.[7]

 

See also

  • Steroid hormones
  • Testosterone
  • Estrogen

 

References

  1. ^ FDA document regading DHEA and SLE
  2. ^ Kawano H, Yasue H, Kitagawa A, et al. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab. 2003 Jul;88(7):3190-5.
  3. ^ Wolkowitz OM, Reus VI, Roberts E, et al. Antidepressant and cognition-enhancing effects of DHEA in major depression. Ann NY Acad Sci. 1995 Dec 29;774:337-9
  4. ^ Eur J Appl Physiol Occup Physiol 1998 Oct;78(5):466-71
  5. ^ Eur J Appl Physiol. 2001 Jul;85(1- 2):177-84
  6. ^ J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):B158-65
  7. ^ Exp Gerontol. 2003 Jan-Feb; 38(1-2):35-46

Further reading

External links

Retrieved from "http://Opengenome.net/index.php?title=DHEA&oldid=27430"