Changes

<td><strong>&nbsp;Interleukin-11 Stem cell factor (IL-11SCF) . </strong>2336. kit ligand (kitL) or steel factor (SLF)</td> <td>&nbsp;Bone &nbsp;marrow stromal cells and IL-1-stimulated fibroblasts&nbsp;, cells of other organs such as brain, kidney, lung, placenta</td> <td>&nbsp;Growth factor for plasmacytomas, megakaryocytes, amd macrophage progenitor cells.&nbspRoles in development of hematopoietic gonadal and pigmental lineages;active in both membrane-biund and secreted forms</td>

<td bgcolor="#cccccc"><strong>&nbsp;Interleukin-12 Thombopoietin (IL-12Tpo) . </strong>Heterodimer containing a p35 subunit of 3060. Megakaryocyte colony-33, p40 subunit of 35-44stimulating factor. NK cells stimulatory factor (NKSF); cytotoxic lymphocyte maturation factor (CLMF)</td> <td bgcolor="#cccccc">&nbsp;Macrophages and dendritic cells&nbsp;Liver, kidney, skeletal muscle</td> <td bgcolor="#cccccc">&nbsp;Important Megakaryocyte lineage-specific growth differentiation factor in inducing differentiation of Th1 subset helper T cells. Also induces interferon gamma that regulates platelet production by T cells and NK cells and enhances NK cell activity.&nbsp;</td>

<td><strong>&nbsp;Interleukin-13 Transforming growth factor beta (ILTGF-13&beta;) . </strong>17~25. Differentiation-inhibiting factor.</td> <td>&nbsp;Activated T cells, mast cells, Many nucleated cell types and NK cells&nbsp;found in platelets</td> <td>&nbsp;Role in Th2 responsesInhibits growth of a number of cell types; upregulates synthesis of IgE affects tissue remodeling, wound repair, develiopment, and suppresses inflammatory responseshematopoiesis. Involved in pathology Exert suppressive effects on the expansion of asthma and some allergic conditionscertain immune-cell populations; switch factor for IgA.&nbsp;</td>

<td bgcolor="#cccccc"><strong>&nbsp;Interleukin-14 Tumor necrosis factor alpha (ILTNF-14&alpha;) . </strong>6052. Cachetin. High molecular weight B cell growth factor (HMW-BCGF)</td> <td bgcolor="#cccccc">&nbsp;Monocytes, macrophages, other cell types including T cells&nbsp; , and fibroblasts</td> <td bgcolor="#cccccc">&nbsp;Enhances B celss proliferation, inhibits antibody synthesisStronf mediator of inflammatory and immune functions. Known to regulate growth and differentiation of a wide variety of cell types. Cytotoxic for many types of transformed cells.&nbsp;</td>

<td><strong>&nbsp;Interleukin-15 (IL-15) </strong>14-15</td> <td>&nbsp;Many cell types but primarily dendritic cells and cells of the monocytic&nbsp;lineage&nbsp;</td> <td>&nbsp;Stimulates T cell proliferation and development and activation of NK cells.&nbsp;</td> </tr> <tr> <td bgcolor="#cccccc"><strong>&nbsp;Interleukin-16 (IL-16) </strong>homotetramer 60; monomer ~17. Lymphocyte chemotatic Tumor necrosis factor beta (LCF)</td> <td bgcolor="#cccccc">&nbsp;T cells &nbsp;</td> <td bgcolor="#cccccc">&nbsp;Stomulates migration of CD4+ T cells, CD4+ monocytes, and eosinophils. Binding of ILTNF-16 by CD4 inhibits HIV sinfection of CD4+ cells&nbsp;.</td> </tr> <tr> <td><strong>&nbsp;Interleukin-17 (IL-17) </strong>28-31. CTLA-8 (cytotoxic lymphocyte-associated antigen8)</td> <td>&nbsp;Primarily CD4+ T cells&nbsp; </td> <td>&nbsp;Supports hematopiesis indirectly by stimulating cytokine production by epithelial, endothelial, and fibroblastic stromal cells. Enhances expression of ICAM-1, thus making cells more adhesive.&nbsp;</td> </tr> <tr> <td bgcolor="#cccccc"><strong>&nbspbeta;Interleukin-18 (IL-18) </strong>18.2, Interferon gamma-inducing factor (IGIF)</td> <td bgcolor="#cccccc">&nbsp;Cells of the monocytic lineage and dendritic cells&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Promotes differentiation of Th1 subset of helper T cells. Induces interferon gamma production of T cells and enhances NK cell cytotoxicity.&nbsp;</td> </tr> <tr> <td><strong>&nbsp;Interleukin-19 (IL-19) </strong>Homotetramer 35-40</td> <td>&nbsp;LPS-stimulated monocytes; other sources also likely&nbsp;</td> <td>&nbsp;Newly discovered member of the IL-10 family of cytokines25. Activity under investigation.&nbsp;</td> </tr> <tr> <td bgcolor="#cccccc"><strong>&nbsp;Interleukin-20 Lymphotoxin (IL-20LT) </strong></td> <td bgcolor="#cccccc">&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Newly discovered cytokine has effects in epidermal tissues; no immune system specific effects yet known.</td> </tr> <tr> <td><strong>&nbsp;Interleukin-21 (IL-21) </strong>15</td> <td>&nbsp;Activated T cells&nbsp;</td> <td>&nbsp;Newly discovered. Enhances cytotoxic activity and gamma interferon production by activated NK cells. Enhances proliferation, gamma interferon production, and cytotoxicity of CD8+ T B cells.&nbsp;</td> </tr> <tr> <td bgcolor="#cccccc"><strong>&nbsp;Interleukin-22 (IL-22)</strong></td> <td bgcolor="#cccccc">&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Newly discovered member of IL-10 cytokine family.</td> </tr> <tr> <td><strong>&nbsp;Interleukin-23 (IL-23) </strong>Heterodimer Mediator of p40 subunit of IL-12 (35-40) inflammation and p19 (18.7)</td> <td>&nbsp;Activated dendritic cells</td> <td>&nbsp;Many of the same biological activities as IL-12&nbsp;</td> </tr> <tr> <td bgcolor="#cccccc"><strong>&nbsp;Interleukin-24 (IL-24) </strong>23immune function. IL10B; MDA7 (melanoma differentiation association protein7)</td> <td bgcolor="#cccccc">&nbsp;Up-regulated in melanoma cells&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Indeuces TNF-&alpha; and IFN-&gamma; and low levels of IL-1&beta;, IL-12, and GM-CSF in human PBMC. Induces selective anti-cancer properties in breast carcinoma cells by promoting p53 independent apoptosis. Member of the IL-10 family.&nbsp;</td> </tr> <tr> <td><strong>&nbsp;Interleukin-25 (IL-25)</strong></td> <td>&nbsp;</td> <td>&nbsp;New member of the IL-17 family. Induces production of IL-4, IL-5, IL-13, and eotaxin. In vivo introduction of IL-25 into the lung can result in airway disease, involving cytokine production, tissue reorganization, mucus secretion, and airway hyperreactivityAffects healing.</td>