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<p align="left"><strong><font face="Times New Roman" size="6">History of <a href="http://bio.cc/Bioinformatics/">Bioinformatics</a></font></strong></p>
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<p><font face="Times New Roman" color="#cc0000" size="4"><strong>1859:</strong></font><font face="Times New Roman" size="4"> </font><font face="Times New Roman" size="3"><strong>Charles Darwin, Cambridge, UK, publishes </strong></font><em><font face="Times New Roman" size="3"><strong>Th</strong></font></em><font face="Times New Roman" size="3"><strong>e O</strong></font><em><font face="Times New Roman" size="3"><strong>rigin of Species</strong></font></em><font face="Times New Roman" size="3"><strong>, vastly strengthening the adaptationist hypothesis.</strong></font></p>
<strong><span style="FONT-FAMILY: Arial"><font face="Times New Roman" size="4">1864:</font></span></strong><span style="FONT-FAMILY: Arial"><font face="Times New Roman"> Ernst Haeckel (Häckel) outlines the essential elements of modern zoological classification</font></span>
<p><span lang="EN-GB" style="FONT-FAMILY: 'Times New Roman'; mso-ascii-font-family: " timesnew="" newtimes=""><strong><font face="Times New Roman" color="#cc3300" size="4">1865:</font><font face="Times New Roman" size="3"> </font></strong></span><font face="Times New Roman" size="3">Gregory Mendel (1823-1884), Austria, <img height="44" alt="img1.gif" src="http://bio.cc/Bioinformatics/img1.gif" width="52" border="0" /> established the genetic inheritance. The theoretical study of genetics. </font><em><font face="Times New Roman">Experiments in Plant Hybridisation</font></em><font face="Times New Roman">. Cambridge, MA: Harvard University Press. His work, in German, was first published in 1865 in the </font><em><font face="Times New Roman">Proceedings of the Brünn Society for Natural History</font></em><font face="Times New Roman">, Brünn, Austria (</font><a href="http://bio.cc/Bioinformatics/history_of_bioinformatics.html#Hewlett"><font face="Times New Roman">Hewlett, 1998</font></a><font face="Times New Roman">). It was ignored for a generation.</font></p>
<p><font face="Times New Roman,Helvetica" color="#cc0000" size="4"><strong>1868:</strong></font><font face="Times New Roman,Helvetica"><font color="#8000ff"> </font></font><font face="Times New Roman,Helvetica" color="#000000">Friedrich </font><a href="http://biopeople.net/Biologists/Friedrich_Miescher"><font face="Times New Roman,Helvetica" color="#000000">Miescher</font></a><font face="Times New Roman,Helvetica" color="#000000"> </font><font face="Times New Roman,Helvetica">- discovery of </font><font face="Times New Roman,Helvetica" color="#000000"><strong>nuclein</strong></font><font face="Times New Roman"> </font><font face="Times New Roman,Helvetica">found in cell nucleus, acidic, rich in <strong>PO<sub>4</sub></strong>,</font><font face="Times New Roman"> </font><font face="Times New Roman,Helvetica">lacks <strong>S </strong>(characteristic of protein).</font><font face="Times New Roman"> </font><font face="Times New Roman,Helvetica">Now know this as <strong>nucleic acid</strong></font><font face="Times New Roman"> </font></p>
<font face="Times New Roman" size="4"><strong>1902:</strong></font><font face="Times New Roman" size="3"> The chromosome theory of heredity is proposed by Sutton and Boveri, working independently. </font>