Difference between revisions of "CD 항원(CD antigen)"
From Opengenome.net
| Line 20: | Line 20: | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td><strong>CD1a, b, c, d, e</strong></td> | + | <td><strong> CD1a, b, c, d, e</strong></td> |
<td> 43-49</td> | <td> 43-49</td> | ||
<td> MHC class I-like structure</td> | <td> MHC class I-like structure</td> | ||
| Line 27: | Line 27: | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td bgcolor="#cccccc"><strong>CD2</strong></td> | + | <td bgcolor="#cccccc"><strong> CD2</strong></td> |
<td bgcolor="#cccccc"> 45-58</td> | <td bgcolor="#cccccc"> 45-58</td> | ||
<td bgcolor="#cccccc"> LFA-2, T11, E-rosette receptor; CD58 binding adhesion molecule</td> | <td bgcolor="#cccccc"> LFA-2, T11, E-rosette receptor; CD58 binding adhesion molecule</td> | ||
| Line 34: | Line 34: | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td><strong>CD3</strong></td> | + | <td><strong> CD3</strong></td> |
| − | <td>γ; 25-28<br /> | + | <td>γ;25-28<br /> |
δ; 20<br /> | δ; 20<br /> | ||
ε; 20 </td> | ε; 20 </td> | ||
| Line 43: | Line 43: | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td bgcolor="#cccccc"><strong>CD4</strong></td> | + | <td bgcolor="#cccccc"><strong> CD4</strong></td> |
<td bgcolor="#cccccc"> 55</td> | <td bgcolor="#cccccc"> 55</td> | ||
<td bgcolor="#cccccc"> L3T4</td> | <td bgcolor="#cccccc"> L3T4</td> | ||
| Line 50: | Line 50: | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td> </td> | + | <td><strong> CD5</strong> </td> |
| − | <td> </td> | + | <td> 58 </td> |
| − | <td> </td> | + | <td> Leu1, T1, Ly-1</td> |
| − | <td> </td> | + | <td> Mature T cells, early thymocytes; small amounts on a subset of mature B cells (B1a B cells) </td> |
| − | <td> </td> | + | <td> Positive or negative modulation of TCR and BCR signaling, depending on the type and developmental stage of cell displaying it</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td> </td> | + | <td bgcolor="#cccccc"><strong> CD6</strong></td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> 105 or 130 </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> T12 </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> Most peripheral T cells, thumocytes, a subset of B cells </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> Adhesion molecule that binds developing thymocytes to thymic epitheral cells; possible co-stimulatory molecule for mature T cells </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td> </td> | + | <td><strong> CD7</strong></td> |
| − | <td> </td> | + | <td> 40</td> |
| − | <td> </td> | + | <td> gp-40 </td> |
| − | <td> </td> | + | <td> Pluripotent hematopoetic cells, T cells, thymocytes </td> |
| − | <td> </td> | + | <td> Not known </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td> </td> | + | <td bgcolor="#cccccc"><strong> CD8</strong></td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> T8, Leu-22 ; a membrane-bound dimer of two chains; αβ heterodimer or αα homodimer</td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> MHC class Ⅰ-restricted T cells, some thymocytes</td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> Coreceptor for MHC class Ⅰ-restricted T cells </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td> </td> | + | <td><strong> CD9</strong></td> |
| − | <td> </td> | + | <td> 24 </td> |
| − | <td> </td> | + | <td> MRP-1, p24 </td> |
| − | <td> </td> | + | <td> Platelets, early B cells, activated B cells, activated T cells, eosinophils, basophils </td> |
| − | <td> </td> | + | <td> Modulation of cell adhesion and migration; trigger of platelet activation </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td> </td> | + | <td bgcolor="#cccccc"><strong> CD10</strong></td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> 100 </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> Common acute lymphoblastic leukemia antigen (CALLA), EC 3.4.24.11 (neprilysin), enkephalinase, gp100, neutral endopeptidase (NEP), metalloendopeptidase </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> B-cell precursors, T-cell precursors, bone-marrow stromalcells </td> |
| − | <td> </td> | + | <td bgcolor="#cccccc"> Protease</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
Revision as of 13:11, 4 September 2006
|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD1a, b, c, d, e | 43-49 | MHC class I-like structure | Dendritic cells, B cells, Langerhans cells, some thymocytes | Display of non-peptide and glycolipid antigens for T-cell responses |
| CD2 | 45-58 | LFA-2, T11, E-rosette receptor; CD58 binding adhesion molecule | T cells, thymocytes, NK cells | Adhesion molecule involved in T-cell activation |
| CD3 | γ;25-28δ; 20ε; 20 |
T3; composed of 3 polypeptide chains: γ, δ, ε | Thmocytes, T cells, NK1-T cells | Essential role in TCR signal transduction and in cell-surface expression of the TCR |
| CD4 | 55 | L3T4 | MHC class Ⅱ-restricted T cells, some thymocytes, monocytes/macrophage, granulocytes | Co-receptor for MHC class Ⅱ-restricted T-cell activation; thymic differentiation marker for T cells; receptor for HIV |
| CD5 | 58 | Leu1, T1, Ly-1 | Mature T cells, early thymocytes; small amounts on a subset of mature B cells (B1a B cells) | Positive or negative modulation of TCR and BCR signaling, depending on the type and developmental stage of cell displaying it |
| CD6 | 105 or 130 | T12 | Most peripheral T cells, thumocytes, a subset of B cells | Adhesion molecule that binds developing thymocytes to thymic epitheral cells; possible co-stimulatory molecule for mature T cells |
| CD7 | 40 | gp-40 | Pluripotent hematopoetic cells, T cells, thymocytes | Not known |
| CD8 | T8, Leu-22 ; a membrane-bound dimer of two chains; αβ heterodimer or αα homodimer | MHC class Ⅰ-restricted T cells, some thymocytes | Coreceptor for MHC class Ⅰ-restricted T cells | |
| CD9 | 24 | MRP-1, p24 | Platelets, early B cells, activated B cells, activated T cells, eosinophils, basophils | Modulation of cell adhesion and migration; trigger of platelet activation |
| CD10 | 100 | Common acute lymphoblastic leukemia antigen (CALLA), EC 3.4.24.11 (neprilysin), enkephalinase, gp100, neutral endopeptidase (NEP), metalloendopeptidase | B-cell precursors, T-cell precursors, bone-marrow stromalcells | Protease |
