Difference between revisions of "Cell Cycle : G2/M Check point"
From Opengenome.net
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| − | <a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g2Pathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g2Pathway.gif</a> | + | <a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g2Pathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g2Pathway.gif</a> <br /> |
| + | <br /> | ||
| + | <table style="WIDTH: 701px; HEIGHT: 853px" cellspacing="1" cellpadding="1" width="701" summary="" border="1"> | ||
| + | <tbody> | ||
| + | <tr> | ||
| + | <td> </td> | ||
| + | <td> </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATM</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">ATR</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATM</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">DNA repair</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATM</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">BRCA1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATR</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">ATM</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATR</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">BRCA1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATR</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CHK2</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATR</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p53</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">ATR</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CHK1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">BRCA1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">DNA repair</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">BRCA1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">ATR-ATM complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">Cyclin B</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">GADD45</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p21</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC25</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">PLK1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">MYT1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">WEE1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CHEK2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p53</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CHEK2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">ATM-ATR complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CHEK2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC25</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">CHEK1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CHK2</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">TP53</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">MDM2</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">TP53</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">DNA-PK</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">TP53</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">ATM-ATR complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">TP53</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CHK2</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">TP53</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">MDM2-p19 complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">GP300</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p53</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">GADD45A</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC2</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">GADD45A</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p53</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">MDM2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p53</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">MDM2</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p19</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">WEE1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC2-Cyclin B complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">WEE1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC34</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">PLK1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC25</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">PLK1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">MYT1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">MYT1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">PLK1</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">MYT1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">p90RSK</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">MYT1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC2-Cyclin B complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center">PLK1</p> | ||
| + | </td> | ||
| + | <td> | ||
| + | <p align="center">CDC2-cyclin B complex</p> | ||
| + | </td> | ||
| + | </tr> | ||
| + | <tr> | ||
| + | <td> | ||
| + | <p align="center"> </p> | ||
| + | </td> | ||
| + | <td> </td> | ||
| + | </tr> | ||
| + | </tbody> | ||
| + | </table> | ||
| + | <br /> | ||
| + | <br /> | ||
| + | Transcription factor<br /> | ||
| + | -BRCA1, p53, | ||
Latest revision as of 22:09, 27 August 2006
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g2Pathway.gif
|
ATM |
ATR |
|
ATM |
DNA repair |
|
ATM |
BRCA1 |
|
ATR |
ATM |
|
ATR |
BRCA1 |
|
ATR |
CHK2 |
|
ATR |
p53 |
|
ATR |
CHK1 |
|
BRCA1 |
DNA repair |
|
BRCA1 |
ATR-ATM complex |
|
CDC2 |
Cyclin B |
|
CDC2 |
GADD45 |
|
CDC2 |
p21 |
|
CDC2 |
CDC25 |
|
CDC2 |
PLK1 |
|
CDC2 |
MYT1 |
|
CDC2 |
WEE1 |
|
CHEK2 |
p53 |
|
CHEK2 |
ATM-ATR complex |
|
CHEK2 |
CDC25 |
|
CHEK1 |
CHK2 |
|
TP53 |
MDM2 |
|
TP53 |
DNA-PK |
|
TP53 |
ATM-ATR complex |
|
TP53 |
CHK2 |
|
TP53 |
MDM2-p19 complex |
|
GP300 |
p53 |
|
GADD45A |
CDC2 |
|
GADD45A |
p53 |
|
MDM2 |
p53 |
|
MDM2 |
p19 |
|
WEE1 |
CDC2-Cyclin B complex |
|
WEE1 |
CDC34 |
|
PLK1 |
CDC25 |
|
PLK1 |
MYT1 |
|
MYT1 |
PLK1 |
|
MYT1 |
p90RSK |
|
MYT1 |
CDC2-Cyclin B complex |
|
PLK1 |
CDC2-cyclin B complex |
|
|
Transcription factor
-BRCA1, p53,
