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Insight: Stem Cells

VolVol. 441, NoNo. 7097 pppp1059-1102

Stem-cell Biology

In recent years, stem cells have been the subject of considerable excitement. Great progress has been made in understanding their mechanisms and unravelling their potential for therapeutic application. Widespread use of stem-cell-based therapies is still a long way off, but could one day benefit vast numbers of patients, including those with cancer, neurodegenerative disorders and heart disease.

This Nature Insight is accompanied by a special stem cells podcast, which features interviews with leading stem-cell researchers and a live discussion on the various scientific and ethical problems in this exciting field.

Readers are invited to join an web forum to exchange views and opinions raised by the Insight articles. There is also a podcast forum for issues discussed in the stem cells podcast.

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Editorial

Stem-cell Biology Free access

Natalie DeWitt

doidoi:10.1038/4411059a


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Glossary

A glossary for stem-cell biology Free access

Austin Smith

doidoi:10.1038/nature04954


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Reviews

Nuclear reprogramming and pluripotency Free access

Konrad Hochedlinger and Rudolf Jaenisch

doidoi:10.1038/nature04955


Asymmetric and symmetric stem-cell divisions in development and cancer Free access

Sean J. Morrison and Judith Kimble

doidoi:10.1038/nature04956


The stem-cell niche as an entity of action Free access

David T. Scadden

doidoi:10.1038/nature04957


Stem cells, ageing and the quest for immortality Free access

Thomas A. Rando

doidoi:10.1038/nature04958


Generation of neuronal variability and complexity Free access

Alysson R. Muotri and Fred H. Gage

doidoi:10.1038/nature04959


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Progress

Stem cells for the treatment of neurological disorders Free access

Olle Lindvall and Zaal Kokaia

doidoi:10.1038/nature04960


Potential of stem-cell-based therapies for heart disease Free access

Deepak Srivastava and Kathryn N. Ivey

doidoi:10.1038/nature04961


Stem-cell therapies for blood diseases Free access

Claudio Bordignon

doidoi:10.1038/nature04962