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<p>An interesting overview of metagenomics is "Welcome to life on the tiniest scales" ; written by Henry Nicholls, in March 17th 2007 New Scientist magazine (paid).</p>
<p>Early environmental gene sequencing cloned specific genes (often the 16S rRNA gene) to produce a profile of diversity in a natural sample. Such work revealed that the vast majority of microbial diversity had been missed by cultivation-based methods. <sup class="reference" id="cite_ref-Hugenholz1998_0-0">[1]</sup> Recent studies use "shotgun" Sanger sequencing or chip-based pyrosequencing to get (mostly) unbiased samples of all genes from all members of sampled communities.</p>
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<h2><span class="mw-headline">History</span></h2>
<h2><span class="mw-headline">External links</span></h2>
<ul>
<li><a class="external text" title="http://www-ab.informatik.uni-tuebingen.de/software/megan/" rel="nofollow" href="http://www-ab.informatik.uni-tuebingen.de/software/megan/" rel="nofollow">MEGAN</a> MEtaGenome ANalyzer. A stand-alone metagenome analysis tool. </li> <li><a class="external text" title="http://dels.nas.edu/metagenomics/" rel="nofollow" href="http://dels.nas.edu/metagenomics/" rel="nofollow">Metagenomics and Our Microbial Planet</a> A website on metagenomics and the vital role of microbes on Earth from the <a class="external text" title="http://nationalacademies.org" rel="nofollow" href="http://nationalacademies.org/" rel="nofollow">National Academies.</a> </li> <li><a class="external text" title="http://books.nap.edu/catalog.php?record_id=11902" rel="nofollow" href="http://books.nap.edu/catalog.php?record_id=11902" rel="nofollow">The New Science of Metagenomics: Revealing the Secrets of Our Microbial Planet</a> A report released by the National Research Council in March 2007. Also, see the <a class="external text" title="http://dels.nas.edu/dels/rpt_briefs/metagenomics_brief_final.pdf" rel="nofollow" href="http://dels.nas.edu/dels/rpt_briefs/metagenomics_brief_final.pdf" rel="nofollow">Report In Brief.</a> </li> <li><a class="external text" title="http://img.jgi.doe.gov/m" rel="nofollow" href="http://img.jgi.doe.gov/m" rel="nofollow">IMG/M</a> The Integrated Microbial Genomes system, for metagenome analysis by the DOE-JGI. </li> <li><a class="external text" title="http://camera.calit2.net/index.php" rel="nofollow" href="http://camera.calit2.net/index.php" rel="nofollow">CAMERA</a> Cyberinfrastructure for Metagenomics, data repository and tools for metagenomics research. </li> <li><a class="external text" title="http://www.scq.ubc.ca/?p=509" rel="nofollow" href="http://www.scq.ubc.ca/?p=509" rel="nofollow">A good overview of metagenomics from the Science Creative Quarterly</a> </li> <li><a class="external text" title="http://www.genomesonline.org/gold.cgi?want=Metagenomes" rel="nofollow" href="http://www.genomesonline.org/gold.cgi?want=Metagenomes" rel="nofollow">list of Metagenome Projects from genomesonline.org</a> </li> <li><a class="external text" title="http://metagenomics.theseed.org" rel="nofollow" href="http://metagenomics.theseed.org/" rel="nofollow">The SEED</a> publicly available, free, metagenomics annotation pipeline for pyrosequences, Sanger sequences, and other sequence approaches. </li>
<li><a title="Human microbiome project" href="http://en.wikipedia.org/wiki/Human_microbiome_project"><font color="#810081">Human microbiome project</font></a> </li>
<li><a class="external text" title="http://www.metahit.eu/" rel="nofollow" href="http://www.metahit.eu/" rel="nofollow">MetaHIT</a> official website for the EU-funded project : Metagenomics of the Human Intestinal Tract </li> <li><a class="external text" title="http://annotathon.univ-mrs.fr/" rel="nofollow" href="http://annotathon.univ-mrs.fr/" rel="nofollow">Annotathon</a> Bioinformatics Training Through Metagenomic Sequence Annotation </li>
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