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DHEA
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<p><span class="mw-headline"><font size="5"><br />
Beneficial Effects</font></span></p>
<p>Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.<sup class="reference" id="_ref-0">[1]</sup> This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).</p>
<p>Supplementation with DHEA has been shown to decrease insulin resistance.<sup class="reference" id="_ref-1">[2]</sup></p>
<p>Long term supplementation has been shown to improve mood and relieve depression.<sup class="reference" id="_ref-2">[3]</sup></p>
<p>It is suggested that DHEA's beneficial effects arise from its antioxidant, antiobesity, antilipofuscin, antilipidperoxidative and thereby anti-aging actions. <span title="Biogerontology."><a href="javascript:AL_get(this, 'jour', 'Biogerontology.');">Biogerontology.</a></span> 2008 Feb 29<br /></p>
<p><span class="mw-headline"><font size="4">Disputed effects</font></span></p>
<p>Hormonal substitution with DHEA, testosterone, and growth hormone is ineffective as anti-aging medicine, while calcium and vitamin d'effectiveness was confirmed in fracture prevention. <span title="Revue médicale suisse."><a href="javascript:AL_get(this, 'jour', 'Rev Med Suisse.');">Rev Med Suisse.</a></span> 2008 Jan 9;4(139):18-20, 22-3<br /><br />The significance of the hormone in health and disease is not fully established. It is postulated that DHEA supplements are beneficial in alleviating:</p>
<ul>
<li>cardiovascular disease </li>