Difference between revisions of "CD121-135"
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<tr> | <tr> | ||
<td><strong> CD121a</strong></td> | <td><strong> CD121a</strong></td> | ||
| − | <td> </td> | + | <td> 80</td> |
| − | <td> </td> | + | <td> IL-1R, IL-1R type 1, type 1 IL-1R </td> |
| − | <td> </td> | + | <td> Thymocytes, T cells </td> |
| − | <td> </td> | + | <td> Type Ⅰ interleukin-1 receptor </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CDw121b</strong></td> | <td bgcolor="#cccccc"><strong> CDw121b</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 60-70</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Il-1R type2, type2 IL-1R </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> B cells, macrophages, monocytes </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Type Ⅰ interleukin-1 receptor </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td><strong> CD122</strong></td> | <td><strong> CD122</strong></td> | ||
| − | <td> </td> | + | <td> 70-75</td> |
| − | <td> </td> | + | <td> Interleukin-2 receptor β chain (IL-2Rβ)</td> |
| − | <td> </td> | + | <td> T cells, B cells, NK cells, monocytes/macrophages </td> |
| − | <td> </td> | + | <td> Critical component of IL-2-and IL-15-mediated signaling</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CD123</strong></td> | <td bgcolor="#cccccc"><strong> CD123</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 70</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> IL-3 receptor α subunit (IL-3Rα) </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Bone-marrow stem cells, granulocytes, monocytes, megakaryocytes </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> IL-3 receptor chain </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td><strong> CD124</strong></td> | <td><strong> CD124</strong></td> | ||
| − | <td> </td> | + | <td> 140</td> |
| − | <td> </td> | + | <td> IL-4R </td> |
| − | <td> </td> | + | <td> Hematopoeitiv and non-hematopoeitic cells </td> |
| − | <td> </td> | + | <td> Receptor subunit of IL-4 and IL-113 </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CDw125</strong></td> | <td bgcolor="#cccccc"><strong> CDw125</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 60</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> IL-5Rα </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Eosinophils, activated B cells, basophils </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Low-affinity receptor for IL-5; α chain of IL-5 receptor </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td><strong> CD126</strong></td> | <td><strong> CD126</strong></td> | ||
| − | <td> </td> | + | <td> 80</td> |
| − | <td> </td> | + | <td> Interleukin-6 receptor (IL-6R); associates with CD130 </td> |
| − | <td> </td> | + | <td> T cells, monocytes, activated B cells, hepatocytes and some other non-hematopoeitic cells </td> |
| − | <td> </td> | + | <td> Receptor for IL-6 </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CD127</strong></td> | <td bgcolor="#cccccc"><strong> CD127</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 65-75, 90</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> IL-7 receptor(IL-7R), IL-7 receptor α (IL-7Rα) p90 I17R </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> B-cell precursors, T cells </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Specific receptor for interleukin 7 </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td><strong> CDw128a</strong></td> | <td><strong> CDw128a</strong></td> | ||
| − | <td> </td> | + | <td> 58-67</td> |
| − | <td> </td> | + | <td> CXCR1, interleukin-8 receptor A (IL-8RA) </td> |
| − | <td> </td> | + | <td> Not known </td> |
| − | <td> </td> | + | <td> Chemokine receptor</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CDw128b</strong></td> | <td bgcolor="#cccccc"><strong> CDw128b</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 58-67</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> CXCR2, interleukin-8 receptor B (IL-8RB) </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Not known </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Chemokine receptor</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td><strong> CD130</strong></td> | <td><strong> CD130</strong></td> | ||
| − | <td> </td> | + | <td> ~130-140</td> |
| − | <td> </td> | + | <td> gp130 </td> |
| − | <td> </td> | + | <td> Low level on almost all cell types</td> |
| − | <td> </td> | + | <td> Receptor subunit required for signal transduction when interleukin 6, interleukin11, leukemia inhibitory factor, ciliary neutrophic factor, oncostatin M, and cardiotrophin-1 bind to their receptors </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CDw131</strong></td> | <td bgcolor="#cccccc"><strong> CDw131</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 120-140</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Common beta subunit </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Most myeloid cells including early progenitors, early B cells </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Receptor subunit required for signal transduction by IL-3, GM-CSF, and IL-5 receptors</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td | + | <td><strong> CD132</strong></td> |
| − | <td | + | <td> 64, 65-70</td> |
| − | <td | + | <td> Common cytokine receptor γ chain, common γ chain</td> |
| − | <td | + | <td> T cells, B cells, NK cells, monocytes/macrophages, neutrophils </td> |
| − | <td | + | <td> Subunit of IL-2, IL-4, IL-7, IL-9, and IL-15 receptors</td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
<td bgcolor="#cccccc"><strong> CD134</strong></td> | <td bgcolor="#cccccc"><strong> CD134</strong></td> | ||
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> 50</td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> OX40 </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Activated T cellls </td> |
| − | <td bgcolor="#cccccc"> </td> | + | <td bgcolor="#cccccc"> Possible adhesion molecule co-stimulator </td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| − | <td | + | <td><strong> CD135</strong></td> |
| − | <td | + | <td> 130</td> |
| − | <td | + | <td> FMS-like tyrosine kinase 3(flt3), Flk-2 in mice, STK-1 </td> |
| − | <td | + | <td> Multipotential, myelomonocytic, and primitive B-cell progenitors </td> |
| − | <td | + | <td> Growth factor receptor for early hematopoeitic progenitors </td> |
</tr> | </tr> | ||
</tbody> | </tbody> | ||
</table> | </table> | ||
Latest revision as of 17:36, 11 September 2006
|
CD antigen |
MW.(kDa) |
Synonyms & Properties |
Leukocyte expression |
Function |
| CD121a | 80 | IL-1R, IL-1R type 1, type 1 IL-1R | Thymocytes, T cells | Type Ⅰ interleukin-1 receptor |
| CDw121b | 60-70 | Il-1R type2, type2 IL-1R | B cells, macrophages, monocytes | Type Ⅰ interleukin-1 receptor |
| CD122 | 70-75 | Interleukin-2 receptor β chain (IL-2Rβ) | T cells, B cells, NK cells, monocytes/macrophages | Critical component of IL-2-and IL-15-mediated signaling |
| CD123 | 70 | IL-3 receptor α subunit (IL-3Rα) | Bone-marrow stem cells, granulocytes, monocytes, megakaryocytes | IL-3 receptor chain |
| CD124 | 140 | IL-4R | Hematopoeitiv and non-hematopoeitic cells | Receptor subunit of IL-4 and IL-113 |
| CDw125 | 60 | IL-5Rα | Eosinophils, activated B cells, basophils | Low-affinity receptor for IL-5; α chain of IL-5 receptor |
| CD126 | 80 | Interleukin-6 receptor (IL-6R); associates with CD130 | T cells, monocytes, activated B cells, hepatocytes and some other non-hematopoeitic cells | Receptor for IL-6 |
| CD127 | 65-75, 90 | IL-7 receptor(IL-7R), IL-7 receptor α (IL-7Rα) p90 I17R | B-cell precursors, T cells | Specific receptor for interleukin 7 |
| CDw128a | 58-67 | CXCR1, interleukin-8 receptor A (IL-8RA) | Not known | Chemokine receptor |
| CDw128b | 58-67 | CXCR2, interleukin-8 receptor B (IL-8RB) | Not known | Chemokine receptor |
| CD130 | ~130-140 | gp130 | Low level on almost all cell types | Receptor subunit required for signal transduction when interleukin 6, interleukin11, leukemia inhibitory factor, ciliary neutrophic factor, oncostatin M, and cardiotrophin-1 bind to their receptors |
| CDw131 | 120-140 | Common beta subunit | Most myeloid cells including early progenitors, early B cells | Receptor subunit required for signal transduction by IL-3, GM-CSF, and IL-5 receptors |
| CD132 | 64, 65-70 | Common cytokine receptor γ chain, common γ chain | T cells, B cells, NK cells, monocytes/macrophages, neutrophils | Subunit of IL-2, IL-4, IL-7, IL-9, and IL-15 receptors |
| CD134 | 50 | OX40 | Activated T cellls | Possible adhesion molecule co-stimulator |
| CD135 | 130 | FMS-like tyrosine kinase 3(flt3), Flk-2 in mice, STK-1 | Multipotential, myelomonocytic, and primitive B-cell progenitors | Growth factor receptor for early hematopoeitic progenitors |
