CD61-75

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD61	110	CD61A, GPⅡb/Ⅲa, β3 integrin chain	Platelets, megakaryocytes, macrophages	Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)
CD62E	140	E-selectin, ELAM-1, LECAM-2	Acutely activated endothelium, chronic inflammatory lesions of skin and synovium	Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sites
CD62L	65	L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1	Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells; bone-marrow lymphocytes and myeloid cells, thymocytes	Adhesion molecule that mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites
CD62P	120	P-selectin, granule membrane protein-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)	Endothelium, platelets, megakaryocytes	Interaction with PSGL-1 to mediate tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration toward sites of inflammation
CD63	40-60	LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA)	Platelets, endothelium, degranulated neutrophils, monocytes, macrophages endothelium	Not known
CD64	72	Fcγ\RI, FCRI	Monocytes, macrophages, bood and germinal-center dendritic cells, PMN activated by IFN-γ or G-CSF, early myeloid-lineage cells	Phagocytosis: receptor-mediated endocytosis of IgG-antigen complexes; antigen capture for presentation to T cells; antibody-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediates
CD65		Ceramide-dodecasaccharide, VIM-2; glycolipid	Myeloid cells	Not known
CD65s		Sialylated-CD65, VIM-2; carbohydrate	Granulocytes, monocytes	Possible involvement with phagocytosis and Ca 2+ influx
CD66a	160-180	NCA-160, biliary glycoprotein (BGP)	Granulocytes, epithelial cells	Adhesion molecule; receptor for Neisseria gonorrheae and N. meningitidis; trigger of neutrophil activation
CD66b	95-100	CD67, CGM6, NCA-95	Granulocytes	Adhesion molecule; trigger of neutrophil activation
CD66c	90	NCA, NCA-50/90	Granulocytes, epithelial cells	Adhesion molecule; trigger of neutrophil activation
CD66d	30	CGM1	Granulocytes	Unclear; receptor for Neisseria gonorrheae and N. meningitidis
CD66e	180-200	Carcinoembryonic antigen (CEA)	Epithelial cells	Unclear; possible adhesion molecule
CD66f	54-72	Pregnancy-specific b1 glycoprotein, SP-1, pregnancy-specific glycoprotein (PSG)	Fetal liver; produced in placenta and released	Unclear; possible involvement in immune regulation and protection of fetus from maternal immune system; necessary for successful pregnancy
CD68	110	gp110, macrosialin	Monocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells, myeloid progenitor cells, subset of CD34+ hematopoeitic progenitor cells, activated T cells, some peropheral-blood B cells	Not known
CD69	60	Activation-inducer molecule (AIM), EA1, MLR3, gp34/28, very early activation (VEA)	Activated leukocytes, inducing T cells, thymocytes, B cells, NK cells, neutrophils, eosinophils, and Langerhans cells; subset of mature thymocytes, germinal-center mantle B cells, some CD4+ germinal-center T cells	Involvement in early events of lymphocyte, monocyte, and platelet activation: promotes Ca2+ influx, synthesis of cytokines and their receptors, induction of c-myc and c-fos proto-oncogene expression; role in promoting lysis mediated by activated NK cells
CD70	75, 95, 170	CD27-ligand, Ki24 antigen	Activated T and B cells and macrophages	Ligand for CD27; possible role in co-stimulation of B and T cells
CD71	190	T9, transferrin receptor	All proliferating cells	Iron uptake: binds ferrotransferrin at neutral pH and internalizes complex to acidic endosomal compartment, where tron is released
CD72	42	Ly-19.2, Ly-32.2, Lyb-2	B cells (except plasma cells)	Not known
CD73	69, 70, 72	Ecto-5', nucleotidase	Subpopulations of T and B cells, many peripheral-blood B cells, follicular dendritic cells, epithelial cells, endothelial cells	Dephosphorylation of purine and pyrimidine ribo-and deoxyribonucleoside monophosphates to their corresponding nucleosides
CD74	33, 35, 41	Class Ⅱ-specific chaperone, Li, invariant chain	B cells, activated T cells, macrophages, activated endothelial and epithelial cells	Intracellular sorting of MHC class Ⅱ molecules
CDw75			B cells, Subpopulation of peripheral-blood T cells, erythrocytes	Cell adhesion; ligand for CD22