CD16-30

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD16	50-80	FCγRⅢA	Macrophage, NK cells, neutrophils	Subunit of low-affinity Fc receptor, involved in phagocytosis of antibody-complexed antien and in antibody-dependent cell-mediated cytotosicity (ADCC)
CDw17		Lactosylceramide (LacCer); carbohydrate antigen	Monocytes, granulocytes, basophils, platelets, subset of peripheral B cells (CD19+), tonsillar dendritic cells	Not known; ability to bind bacteria for possible role in phagocytosis
CD18	95	β2 integrin chain;  β subunit that combines with CD11a, CD11b, or CD11c subunit to form integrins	All leukocytes	Adhesion and signaling in the hematopoietic system (see entries for CD11a, CD11b, and CD11c)
CD19	>120	B4	Follicular dendritic cells, B cells from earliest recognizable B-lineage cells during development to B-cell blasts but lost on maturation to plasma cells	Part of B-cell coreceptor with CD21 and CD81; a critical signal transduction molecule that regulates B-cell development, activation, and differentiation
CD20	33	B1, Bp35	B cells	Not known
CD21	145 (membrane form) 130 (soluble form)	C3d receptor, CR2, Epstein Barr virus receptor (EBV-R)	B cells, follicular dendritic cells, subset of immature thymocytes	Receptor for EBV, C3d, C3dg, and iC3b; with CD19 and CD81, part of the B-cell coreceptor, a large signal-transduction complex
CD22	140	BL-CAM, Lyb8 in mouse	Surface of mature B cells, cytoplasm of late pro-and early pre-B cells	Adhesion molecule; signaling molecule
CD23	45	B6, BLAST-2, FcεRⅡ, Leu-20 ; low-affinity IgE receptor	Human B cells, monocytes follicular dendritic cells	Regulation of IgE synthesis; trigger to release TNF, IL-1, IL-6, and GM-CSF from human monocytes
CD24	35-45	BA-1, heat-stable antigen (HSA) in mouse	B-cell lineage but lost at plasma-cell stage, mature granulocytes	Not known
CD25	55	IL-2 receptor α chain, IL-2R, Tac antogen	PHA-stimulated T cells; anti-IGM-stimulated B cells, LPS-stimulated monocytes/macrophages	α subunit of receptor for cytokine IL-2
CD26	110, 120	EC 3.4.14.5, adenosine deaminase-binding protein (ADA-binding protein), dipeptidylpeptidase Ⅳ (DPV Ⅳ ectoenzyme)	Mature of activated T cells, B cells, NK cells, macrophages	Co-stimulatory molecule in T-cell activation
CD27	55	SI52, T14	Mature thymocytes, activated T cells and B cells, NK cells, macrophages, most peropheral T cells, memory-type B cells	Mediation of a co-stimulatory signal for T- and B-cell activation; role in murine T-cell development
CD28	90 (homodimeric form)	T44, Tp44	Matur CD3+ thymocytes, most peripheral T cells, plasma cells	Co-stimulation of T-cell proliferation and cytokine production upon binding CD80 or CD86
CD29	130	β1 integrin chain, GP, platelet GPⅡa, VLA-β chain	Leukocytes	β subunit of VLA-1 integrin
CD30	120	Ber-H2 antigen, Ki-1 antigen	Activated T cells, activated B cells, activated NK cells, monocytes	Stimulation of proliferation or induction of cell death, depending upon conditions and cell type expressing it