CD1-15

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD1a, b, c, d, e	43-49	MHC class I-like structure	Dendritic cells, B cells,  Langerhans cells, some thymocytes	Display of non-peptide and glycolipid antigens for T-cell responses
CD2	45-58	LFA-2, T11, E-rosette receptor; CD58 binding adhesion molecule	T cells, thymocytes, NK cells	Adhesion molecule involved in T-cell activation
CD3	γ;25-28 δ; 20 ε; 20	T3; composed of 3 polypeptide chains: γ, δ, ε	Thmocytes, T cells, NK1-T cells	Essential role in TCR signal transduction and in cell-surface expression of the TCR
CD4	55	L3T4	MHC class Ⅱ-restricted T cells, some thymocytes, monocytes/macrophage, granulocytes	Co-receptor for MHC class Ⅱ-restricted T-cell activation; thymic differentiation marker for T cells; receptor for HIV
CD5	58	Leu1, T1, Ly-1	Mature T cells, early thymocytes; small amounts on a subset of mature B cells (B1a B cells)	Positive or negative modulation of TCR and BCR signaling, depending on the type and developmental stage of cell displaying it
CD6	105 or 130	T12	Most peripheral T cells, thumocytes, a subset of B cells	Adhesion molecule that binds developing thymocytes to thymic epitheral cells; possible co-stimulatory molecule for mature T cells
CD7	40	gp-40	Pluripotent hematopoetic cells, T cells, thymocytes	Not known
CD8		T8, Leu-22 ; a membrane-bound dimer of two chains; αβ heterodimer or αα homodimer	MHC class Ⅰ-restricted T cells, some thymocytes	Coreceptor for MHC class Ⅰ-restricted T cells
CD9	24	MRP-1, p24	Platelets, early B cells, activated B cells, activated T cells, eosinophils, basophils	Modulation of cell adhesion and migration; trigger of platelet activation
CD10	100	Common acute lymphoblastic leukemia antigen (CALLA), EC 3.4.24.11 (neprilysin), enkephalinase, gp100, neutral endopeptidase (NEP), metalloendopeptidase	B-cell precursors, T-cell precursors, bone-marrow stromalcells	Protease
CD11a	180	α-L integrin chain, LFA-1 α (leukocyte function-associated molecule-1 α) chain; forms LFA-1 by association with CD18	Monocytes, ,acrophages, granulocytes, lymphocytes	Subunit of LFA-1. a membrane glycoprotein that provides cell-cell adhesion by interaction with ICAM-1 (intercellular adhesion molecule-1)
CD11b	165	C3biR, CR3; α chain of MAC-1 integrin; forms MAC-1 by association with CD18	Granulocytes, monocytes, NK cells, subset of T cells, subsets of B cells	Subunit of MAC-1, which mediates interactions og neutrophils and monocytes with stimulated endothelium, phagocytosis of particles coated with iC3b or IgG, spreading or chemotaxis of leukocytes; ligand-binding molecule that binds C3b, ICAM-1 (CD54), ICAM-2 (CD102), and fibrinogen
CD11c	145	α-X integrin chain,  αxβ2, α chain of integrin CR4, leukocte surface antigen, p150, 95 ; forms CR by association with CD18	Monocytes, macrophage, NK cells, granulocytes, subset of T cell, subset of B cells	Subunit of complex with CD18 that is similar to CD 11b/CD18 complex, with which it acts cooperatively; the major form of CD11/CD18 on tissue macrophage
CD12w	90-120		Monocytes, granulocytes, platelets	Not known
CD13	150	Aminopeptidase N (APN), EC 3.4.11.2, gp150	Early progenitors of granulocytes and monocytes (CFU-GM), mature granulocytes and monocytes, bone-marrow stromal cells, osteoclasts, a small number of lasrge granular lymphocytes	Not known
CD14	53	LPS receptor (LPS-R)	Monocytes, macrophages, granulocytes (weak expression)	Receptor for endotoxin (lipopolysaccharide [LPS]), activating monocytes or neutrophils to release cytokines (TNF) and up-regulate adhesion molecules when LPS is bound
CD15	Undefined	Lewis X, Lex, SSEA-1, 3-FAL, 3-FL, LNFP Ⅲ, (lacto-N-neo-fucopentoseⅢ); poly-N-acetyl lactosamine, carbohydrate polymer of indefinite MW	Not known	Not known
CD15s	Undefined	Sialyl Lewis X (sLex), sialylated Lewis X (SLe-x); poly- N-acetyl lactosamine, carbohydrate polymer of indefinite MW	Not known	Not known