Difference between revisions of "한국인 햅맵과제"

From Opengenome.net
Line 47: Line 47:
 
<br /><strong>기대효과</strong><br /><!--StartFragment-->
 
<br /><strong>기대효과</strong><br /><!--StartFragment-->
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">과제를 통해 구축된 한국인 HapMap 데이터베이스와 검색시스템은 국내 연구자들이 질병연관 연구를 수행할 때 데이터마이닝 시스템으로 활용되어 암, 당뇨병 등과 같은 복합질병의 유전자를 찾는데 중요한 정보를 제공하게 될 것이며, 궁극적으로는 개인별 맞춤약물개발과 같은 신약개발의 중요한 자료로 이용될 수 있을 것임<br /><br /><!--StartFragment-->&nbsp;<!--StartFragment-->
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">과제를 통해 구축된 한국인 HapMap 데이터베이스와 검색시스템은 국내 연구자들이 질병연관 연구를 수행할 때 데이터마이닝 시스템으로 활용되어 암, 당뇨병 등과 같은 복합질병의 유전자를 찾는데 중요한 정보를 제공하게 될 것이며, 궁극적으로는 개인별 맞춤약물개발과 같은 신약개발의 중요한 자료로 이용될 수 있을 것임<br /><br /><!--StartFragment-->&nbsp;<!--StartFragment-->
−
<p class="HStyle0"><span style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">&gt;&gt;&nbsp;주요 제공 기능</span></p>
+
<p class="HStyle0"><span style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">주요 제공 기능</span></p>
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- Haploview: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype reconstruction, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">LD　Block partition, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Tagging SNP prediction, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Disease Association</span></p>
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- Haploview: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype reconstruction, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">LD　Block partition, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Tagging SNP prediction, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Disease Association</span></p>
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- PHASE: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Recombination rate calculation</span></p>
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- PHASE: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Recombination rate calculation</span></p>
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p>
 
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p>
 
</span></p>
 
</span></p>
 +
<p><br /><strong>엔코드 영역</strong><br /><!--StartFragment--></p>
 +
<p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">bSNP에 등록된 모든 SNP와 추가적으로 resequencing을 통해 새로 발굴한 모든 SNP에 대해 </span><span style="FONT-SIZE: 11.5pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">보다 조밀한 간격으로 </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">genotyping 실험을 진행하였다. 이 연구에서는 10개의 </span><span style="FONT-SIZE: 11.5pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Hapmap ENCODE 중에서 </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">ENm010 영역을 분석에 사용하였다. </span></p>
 +
<p class="HStyle0" style="TEXT-ALIGN: center">
 +
<table style="BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium none; BORDER-BOTTOM: medium none; BORDER-COLLAPSE: collapse" cellspacing="0" cellpadding="0" border="1">
 +
    <caption align="bottom">
 +
    <p class="HStyle0">표 1 International HapMap ENCODE 영역 </p>
 +
    </caption>
 +
    <tbody>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ccffcc" height="38">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Region Name</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" bgcolor="#ccffcc" height="38">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Chromosome band</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" bgcolor="#ccffcc" height="38">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Genomic interval </p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" bgcolor="#ccffcc" height="38">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Genotyping group</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="17">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr112 </p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="17">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">2p16.3 </p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="17">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr2:51633239..52133238</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="17">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">McGill-GQIC, Perlegen</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr131&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">2q37.1&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr2:234778639..235278638&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">McGill-GQIC, Perlegen</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr113&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">4q26&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr4:118705475..119205474&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Broad, Perlegen</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENm010&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">7p15.2&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr7:26699793..27199792&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">UCSF-WU, Perlegen</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENm013&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">7q21.13&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr7:89395718..89895717&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Broad, Perlegen</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENm014&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">7q31.33&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr7:126135436..126632577&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Broad, Perlegen</p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr321 </p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">8q24.11&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr8:118769628..119269627&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Illumina, Perlegen </p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr232&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">9q34.11&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr9:127061347..127561346&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Illumina, Perlegen </p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr123&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">12q12&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr12:38626477..39126476&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">BCM, Perlegen </p>
 +
            </td>
 +
        </tr>
 +
        <tr>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="70" bgcolor="#ffffc4" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">ENr213&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="95" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">18q12.1&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="181" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: left">Chr18:23717221..24217220&nbsp;</p>
 +
            </td>
 +
            <td style="BORDER-RIGHT: #000000 0.4pt solid; PADDING-RIGHT: 1.4pt; BORDER-TOP: #000000 0.4pt solid; PADDING-LEFT: 1.4pt; PADDING-BOTTOM: 1.4pt; BORDER-LEFT: #000000 0.4pt solid; PADDING-TOP: 1.4pt; BORDER-BOTTOM: #000000 0.4pt solid" valign="middle" width="186" height="23">
 +
            <p class="HStyle0" style="TEXT-ALIGN: center">Illumina, Perlegen </p>
 +
            </td>
 +
        </tr>
 +
    </tbody>
 +
</table>
 +
<br /></p>
 
</span>
 
</span>

Revision as of 08:20, 14 April 2006

 한국인 HapMap 데이터베이스 개발

목표:  한국인 HapMap 과제에서 생산된 SNP 및 Haplotype 데이터를 D/B로 구축하고 LD 분석방법을 개발하며, 통합적인 HapMap 데이터마이닝 시스템을 구축함

연구내용: 

○ 국내 SNP 및 Haplotype 데이터의 D/B 구축

  •   국내 SNP 및 Haplotype 데이터의 수집 기능 강화
  •   구축 된 D/B의 검색 기능 개선

○ LD 및 기타 분석 프로그램 개발

  •   LD block을 이용한 Population comparison system 개발
  •   자동화된 SNP 및 haplotype 분석 프로그램 개발

○ 각종 유전자정보와 연계된 HapMap 검색 시스템 구축

  •   유전자 별 HapMap 검색 시스템 구축
  •   ENCODE 부위별 HapMap 검색 시스템 구축

○ 통합적인 포탈 시스템 구축

  •   dbSNP 및 International HapMap 데이터의 포탈 기능 구축
  •   자동화된 통합적인 데이터의 포탈 기능 구축 

○ 통합적인 HapMap 데이터마이닝 시스템 구축

  •   인종 간 HapMap 비교 검색 시스템 구축
  •   유전자 및 부위별 HapMap 검색 시스템의 기능 강화


기대효과

과제를 통해 구축된 한국인 HapMap 데이터베이스와 검색시스템은 국내 연구자들이 질병연관 연구를 수행할 때 데이터마이닝 시스템으로 활용되어 암, 당뇨병 등과 같은 복합질병의 유전자를 찾는데 중요한 정보를 제공하게 될 것이며, 궁극적으로는 개인별 맞춤약물개발과 같은 신약개발의 중요한 자료로 이용될 수 있을 것임

 

주요 제공 기능

- Haploview: Haplotype reconstruction, LD　Block partition, Tagging SNP prediction, Disease Association

- PHASE: Recombination rate calculation

- TCS: Haplotype Maximum Parsimony Tree construction


엔코드 영역

bSNP에 등록된 모든 SNP와 추가적으로 resequencing을 통해 새로 발굴한 모든 SNP에 대해 보다 조밀한 간격으로 genotyping 실험을 진행하였다. 이 연구에서는 10개의 Hapmap ENCODE 중에서 ENm010 영역을 분석에 사용하였다.

표 1 International HapMap ENCODE 영역

Region Name

Chromosome band

Genomic interval

Genotyping group

ENr112

2p16.3

Chr2:51633239..52133238

McGill-GQIC, Perlegen

ENr131 

2q37.1 

Chr2:234778639..235278638 

McGill-GQIC, Perlegen

ENr113 

4q26 

Chr4:118705475..119205474 

Broad, Perlegen

ENm010 

7p15.2 

Chr7:26699793..27199792 

UCSF-WU, Perlegen

ENm013 

7q21.13 

Chr7:89395718..89895717 

Broad, Perlegen

ENm014 

7q31.33 

Chr7:126135436..126632577 

Broad, Perlegen

ENr321

8q24.11 

Chr8:118769628..119269627 

Illumina, Perlegen

ENr232 

9q34.11 

Chr9:127061347..127561346 

Illumina, Perlegen

ENr123 

12q12 

Chr12:38626477..39126476 

BCM, Perlegen

ENr213 

18q12.1 

Chr18:23717221..24217220 

Illumina, Perlegen


Retrieved from "http://Opengenome.net/index.php?title=한국인_햅맵과제&oldid=9067"