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<p> </p><p style="margintext-align: 0cm 0cm 0pt" class="MsoNormalcenter"> <span langstyle="ENbackground-UScolor: #ffffff"> <font size/span><span style="2color: #0000ff"><font facespan style="맑은 고딕background-color: #ffffff">Korean Personal Genome Project(KPGP)<ospan style="font-size:pxx-large"></o:pb></span style="font-family: Times New Roman">K</fontspan></b></span></span></pspan><p span style="margincolor: 0cm 0cm 0pt" class="MsoNormal#000000"><span langstyle="ENfont-size: xx-USlarge"><font size="2"b><font facespan style="맑은 고딕font-family: Times New Roman">KPGP? KPGP! orean<o:p/span></o:pb></fontspan></fontspan></span></p><p style="marginfont-size: 0cm 0cm 0ptxx-large" class><span style="MsoNormalcolor: #808080"><b><span langstyle="ENfont-USfamily: Times New Roman"><font sizespan style="2color: #cc0000">P<font face/span><span style="맑은 고딕color: #333333">Korean Personal Genome Project (“KPGP”) is a participative research project established by Genome Research Foundation (GRF). The international Personal Genome Project (PGP), led by U.S. none<span style="background-profit research group, is founded in 2006 and seeking a diverse range of volunteers with the purpose of improving human health. In concordance with the international PGP, KPGP has started to improve Korean people's health and medical welfare. <o:pcolor: #ffffff">ersonal</o:pspan></fontspan></fontspan style="background-color: #ffffff"></span></p><p stylespan style="margincolor: 0cm 0cm 0pt" class="MsoNormal#cc0000"><span langstyle="ENbackground-UScolor: #ffffff">G</span></span><font sizespan style="2color: #666666">enome<font face/span> <span style="맑은 고딕color: #cc0000">Vision P<o:p/span></o:pspan></fontb></fontspan></span></p><p span style="margincolor: 0cm 0cm 0pt#999999" class><span style="MsoNormalfont-size: xx-large"><b><span langstyle="ENfont-USfamily: Times New Roman">roject<font size/span></b></span></span><span style="2color: #c0c0c0"><font faceb><span style="맑은 고딕font-size: large">KPGP is aiming to advance science research, in order to promote human health and welfare with the keep of geopme technology.<ospan style="font-family:pComic Sans MS"> </o:pspan></fontspan></fontb></span></p><p span style="margincolor: 0cm 0cm 0pt#808080" class><span style="MsoNormalfont-size: large"><span langstyle="ENfont-USfamily: Comic Sans MS"> <oimg style="height: 125px; width:p><font size126px" alt="" width="2130" faceheight="맑은 고딕130" src="/userfiles/1.png"> </font></o:pspan></span> </p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><font size="2"><font face="맑은 고딕">Mission <o:p></o:p></font></font></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><font size="2"><font face="맑은 고딕">- to build a standard Koarea genetic information database<o:p></o:p></font></font></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><o:p><font size="2" face="맑은 고딕"span> </font></o:p></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><font size="2"><font face="맑은 고딕">- to activate the participative genome research<o:p></o:p></font></font></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><o:p><font size="2" face="맑은 고딕"> </font></o:p></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><font size="2"><font face="맑은 고딕">- to develop genome sequencing and analysis technologies in the age of personal genetic information services<o:p></o:p></font></font></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><o:p><font size="2" face="맑은 고딕"> </font></o:p></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><font size="2"><font face="맑은 고딕">- to establish an open community if sharing ethical, social, and legal issued in regard togenetic information<o:p></o:p></font></font></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><o:p><font size="2" face="맑은 고딕"> </font></o:p></span></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal" </p><h2>Introduction<span lang="EN-US"/h2><font size="2"div><font facespan style="맑은 고딕font-size: small">Research Korean Personal Genome Project (KPGP) is a research project by <o:p/span><a href="http:/o:p></font><genomefoundation.org/index.php/Main_Page"><span style="font-size: small">Genome Research Foundation</span></pa><p span style="marginfont-size: 0cm 0cm 0pt" class="MsoNormalsmall">(GRF). It is a part of PGP (The international </span lang><a href="EN-UShttp://www.personalgenomes.org/"><font sizespan style="2"><font face="맑은 고딕-size: small">Korean reference genome projectPersonal Genome Project<o:p/span></o:pa></span style="font-size: small">(PGP).</fontspan></span></pdiv><p style="margin: 0cm 0cm 0pt" class="MsoNormal"h2>Mission<span lang="EN-US"/h2><o:pul> <font size="2" face="맑은 고딕"li> to function as Korean center for PGP (Harvard Medical School, George Church lab)</font></o:pli> </spanli> to build a standard Korean genetic information database</pli> <li> to activate the participative genome research<p style="margin: 0cm 0cm 0pt" class="MsoNormal"/li> <span lang="EN-US"li> to develop genome sequencing and analysis technologies in the age of personal genetic information services<font size="2"/li> <font face="맑은 고딕">Rare diseases reference genome project<o:pli> to establish an open community if sharing ethical, social, and legal issued in regard to genetic information</o:pli></fontul></fonth2>Research</spanh2></pul> <p style="margin: 0cm 0cm 0pt" class="MsoNormal"li>Korean reference genome project<span lang="EN-US">/li> <o:pli><font size="2" face="맑은 고딕"> Rare diseases reference genome project</fontli> </o:pli>HLA alleles reference standard data production project</spanli></pul><h2>Participation </h2><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"b>Genetic Information Participation<font size="2"/b><font face="맑은 고딕"/p>HLA alleles reference standard data production project<o:<p>It is a public participation. The human genetics education, screening and participant`s willingness determine an individual's participation. </o:p></fontp></fontb>Research Participation </spanb></p><p style="margin: 0cm 0cm 0pt" class="MsoNormal">>People who have research experiences in the field of human genetics, or who are willing to contribute to KPGP can participate through screening. <span lang="EN-US"/p><o:p><font size="2" face="맑은 고딕"> b>Company Participation </fontb></o:p></spanp>Institutes and companies could participate. Sponsorship can greatly help KPGP`s activation.</p><p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENbr />Human genome researches have developed rapidly since the human genome project was completed in 2003. Recently large-US"scale production of human genome data is available with the advent of Next Generation Sequencing (NGS).</p><font size="2"p>Genome Research Foundation (GRF), as a non-<font facespan style="맑은 고딕font-size: larger">Participation <o:p></o:p></font></font>profit foundation, determines </span><to open Korean genome data and the current available data of human genome sequence and analysis for free to allow researchers to study. Under the circumstances, OPEN KPGP started on 2011.</p><p> </p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-US"><font size="2"><: 18pt; font face="-family: "맑은 고딕"><span style=""; font-weight: bold; color: black; language: en-US; mso-spacerunascii-font-family: yes"> '맑은 고딕';</span>Genetic Information Participation It is public participation, and human human genetics education, screening and participant`s willingness determined an individualmso-fareast-font-family: '맑은 고딕's participation; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.<span style="0pt; mso-spaceruncolor-index: yes1"> Genetic Data Usage Agreement for Research</span>Research Participation People who have research experiences in the field of human genetics, or who are willing to contribute to KPGP can participate through screening.<span style="msofont-size: 18pt; font-spacerunfamily: yes"> quot;맑은 고딕"; </span>Company Participation Institutes and companies could participate. Sponsorship can greatly help KPGP`s activation. OPEN KPGP? OPEN KPGP! <ocolor: black; language:p></oen-US; mso-ascii-font-family:p></'맑은 고딕'; mso-fareast-font></-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 1"></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-bidi: embed; direction: ltr; text-US"><font size="2align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><font facespan style="font-size: 18pt; font-family: "맑은 고딕">Human genome researches have developed rapidly since the human genome project was completed in 2003. Recently large"; color: black; language: en-US; mso-ascii-font-scale production of human genome data is available with the advent of Next Generation Sequencing (NGS).<ofamily:p></o'맑은 고딕'; mso-fareast-font-family:p></'맑은 고딕'; mso-bidi-font></-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 1"> </span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><o:p><font sizespan style="2" face="맑은 고딕"> font-family: '맑은 고딕';</font></o-weight: bold; color:p></span></p><p style="marginblack; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">Genome Research Foundation (GRF), as a non'; mso-bidi-font-profit foundation, determined to open Korean genome data and the current available data of human genome sequence and analysis for free to allow researchers to studyfamily: +mn-cs; mso-font-kerning: 12. Under the circumstances, OPEN KPGP started on 2011. <o0pt; mso-color-index:p13">1) Data Type</o:p></font></fontspan></span></p><p style="margin-bottom: 0pt; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0cm 0cm 0pt" class="MsoNormal; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><o:p><font size="2" facespan style="font-family: '맑은 고딕"> '; color: black; language: en-US;</mso-ascii-font></o-family:p></span'맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Every derived genetic information should be approved by relevant facility board.</span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><o:p><font size="2" facespan style="font-family: '맑은 고딕"> ';</font></ocolor:p></span></p><p style="marginblack; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><o; mso-ascii-font-family:p><'맑은 고딕'; mso-fareast-font size="2" face="-family: '맑은 고딕"> ';</mso-bidi-font></o-family:p></+mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">1. Genetic information data- Individual's sequenced DNA and analyzed data.</span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-US"><bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font -size="2: larger"><font facespan style="font-family: '맑은 고딕"><'; color: black;How to download>language: en-US;<omso-ascii-font-family:p></o'맑은 고딕'; mso-fareast-font-family:p></'맑은 고딕'; mso-bidi-font></-family: +mn-cs; mso-font>-kerning: 12.0pt; mso-color-index: 13">2. Clinical information data- Clinical information does not include family tree, Phenotype and family medical history.</span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-bidi: embed; direction: ltr; text-US"><font sizealign: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="2font-size: larger"><font facespan style="font-family: '맑은 고딕">After accessing to the OPEN KPGP website, select the desired data from DATA DOWNLOAD to download it through the Web and FTP. <o'; font-weight: bold; color:p></oblack; language:p></en-US; mso-ascii-font></-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">2) The Commission Process</span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-USbidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font -size="2: larger"><font facespan style="font-family: '맑은 고딕">Please understand that the downloading may be very slow due to Network load. (The speed of downloading 20 people&rsquo'; color: black;s data through KT cloud is stable, please use it as an alternativ.) <olanguage:p></oen-US; mso-ascii-font-family:p></'맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font></-family: +mn-cs; mso-font></span></p><p style="margin-kerning: 0cm 0cm 12.0pt; mso-color-index: 13" class="MsoNormal">1. Bioethics committee of Genome Research Foundation will make a decision through policy reviews and case consultation.</span></span lang="EN-US"><o:/p><font sizep style="2" face="맑은 고딕margin-bottom: 0pt; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"> </span style="font></o-size:plarger"></span></p><p stylestyle="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENfont-US"><ofamily:p><font size="2" face="'맑은 고딕"> ';</font></ocolor:p></span></p><p style="marginblack; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><o; mso-ascii-font-family:p><'맑은 고딕'; mso-fareast-font size="2" face="-family: '맑은 고딕"> '; mso-bidi-font-family: +mn-cs;</mso-font-kerning: 12.0pt; mso-color-index: 13">2. The Standards Commission</o:pspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><font sizespan style="2"><font face="-family: '맑은 고딕"><';Hard disk Request>color: black;<olanguage:p></oen-US; mso-ascii-font-family:p></'맑은 고딕'; mso-fareast-font></-family: '맑은 고딕'; mso-bidi-font><-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">This commission should be controlled by Korea National Institute for Bioethics Policy.</span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-bidi: embed; direction: ltr; text-US"><font sizealign: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="2font-size: larger"><font facespan style="font-family: '맑은 고딕">You can get data hard disks by requesting it to the administrator. However, the hard disk and processing costs will occur. <o'; color: black; language: en-US; mso-ascii-font-family:p></o'맑은 고딕'; mso-fareast-font-family:p></'맑은 고딕'; mso-bidi-font></-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Research, associate with potential social risks, </span></p><p span style="marginfont-family: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN'맑은 고딕'; color: black; language: en-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">Cost <o:p></o'; mso-bidi-font-family:p></+mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">eugenical</fontspan></span></p><p style="marginfont-family: '맑은 고딕'; color: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENblack; language: en-US"><; mso-ascii-font size="2"><font face="-family: '맑은 고딕">'; mso-fareast-font- Hard disk<ofamily:p></o'맑은 고딕'; mso-bidi-font-family:p></+mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">problem and discrimination on the basis of genetic information when it comes to any aspects of physical looking, should be forbidden. </fontspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><font sizespan style="2"><font face="-family: '맑은 고딕">'; color: black; language: en- Operating costs (labor and server equipment operating costs).<oUS; mso-ascii-font-family:p></o'맑은 고딕'; mso-fareast-font-family:p></'맑은 고딕'; mso-bidi-font>-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">3. The Commission Process</fontspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-bidi: embed; direction: ltr; text-align: left; margin-US"><font size=left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="2font-size: larger"><font facespan style="font-family: '맑은 고딕">- Shipping '; color: black; language: door to door delivery(domestic only) / international shipping en-US; mso-ascii-font-family: please contact. (info@kpgp.kr)<o'맑은 고딕'; mso-fareast-font-family:p></o'맑은 고딕'; mso-bidi-font-family:p></+mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Research project and IRB document, approved in each countries, will be required. If there is no provision for IRB approval, User must agree with additional consent documents that embodies the purpose of the data.</fontspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><o:p><font size="2" facespan style="font-family: '맑은 고딕"> ';</font></ocolor:p></span></p><p style="marginblack; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕"><span style="'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-spaceruncolor-index: yes13"> </span>Sample no. Cost4. Evaluation (excluding V.A.TIt will take at least one week) <o:p></o:p></font></fontspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-US"bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font -size="2: larger"><font facespan style="font-family: '맑은 고딕">10 115,000 (KRW) <o'; font-weight:p></obold; color:p></font></font></span></p><p style="marginblack; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">20 170,000 (KRW) <o'; mso-bidi-font-family:p></o+mn-cs; mso-font-kerning: 12.0pt; mso-color-index:p13">3) Policy </font></fontspan></span></p><p style="marginfont-family: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN'맑은 고딕'; font-weight: bold; color: black; language: en-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">30 260,000 (KRW) <o'; mso-bidi-font-family: +mn-cs; mso-font-kerning:p></o12.0pt; mso-color-index:p13">Agrement</fontspan></font></span></p><p style="marginfont-family: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN'맑은 고딕'; font-weight: bold; color: black; language: en-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">40 340,000 (KRW) <o'; mso-bidi-font-family: +mn-cs; mso-font-kerning:p></o12.0pt; mso-color-index:p13"></font></fontspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-US"><font size="2"><font face="맑은 고딕: larger"><span style="msofont-spacerunfamily: yes"> '맑은 고딕';</span>Sample no. Cost(excluding V.A.T) <ocolor:p></oblack; language:p></en-US; mso-ascii-font></font>-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Informed consent shall be documented by the use of a written consent form approved by the IRB, and signed by the subject or the subject's legally </span></p><p span style="marginfont-family: '맑은 고딕'; color: black; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">10 310,000 (KRW) <o'; mso-bidi-font-family: +mn-cs; mso-font-kerning:p></o12.0pt; mso-color-index:p13">authourized</fontspan></font></span></p><p span style="marginfont-family: '맑은 고딕'; color: black; language: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">20 530,000 (KRW) representative.<o:p></o:p></font></font/span></span></p><p style="margin-bottom: 0pt; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0cm 0cm 0pt" class="MsoNormal; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><font sizespan style="2"><font face="-family: '맑은 고딕">30 750,000 (KRW) <o'; color:p></oblack; language:p></en-US; mso-ascii-font>-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">And if necessary, the committee may request, require or otherwise obtain detailed investigation.</fontspan></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span langstyle="ENfont-USsize: larger"><font sizespan style="2"><font face="-family: '맑은 고딕">40 880,000 (KRW) <o'; color:p></oblack; language:p></en-US; mso-ascii-font></-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Data Release</span></span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-USbidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><ospan style="font-size:plarger"><font size="2" facespan style="font-family: '맑은 고딕"> '; color: black;</font></o:p></span></p><p style="marginlanguage: 0cm 0cm 0pt" class="MsoNormal"><span lang="ENen-US"><o; mso-ascii-font-family:p><'맑은 고딕'; mso-fareast-font size="2" face="-family: '맑은 고딕"> '; mso-bidi-font-family: +mn-cs;</mso-font></o-kerning:p></span>12.0pt; mso-color-index: 13">Any additional costs to the subject that may result from participation in the research.</span></span></p><p style="margin-bottom: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN; unicode-bidi: embed; direction: ltr; text-US"><align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font -size="2: larger"><font facespan style="font-family: '맑은 고딕"><';Data Usage>font-weight: bold; <ocolor:p></oblack; language:p></en-US; mso-ascii-font></-family: '맑은 고딕'; mso-fareast-font></span></p><p style="margin-family: 0cm 0cm '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt" class="MsoNormal; mso-color-index: 13">4) Data Source </span lang="EN-US"><font sizespan style="2"><font face="-family: '맑은 고딕">1. The genome data are provided by Genome Research Foundation. Anyone can use the data openfreely. <o'; font-weight: bold; color:p></oblack; language:p></en-US; mso-ascii-font></-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Agrement</span></p><p span style="marginfont-family: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN'맑은 고딕'; font-weight: bold; color: black; language: en-US"><; mso-ascii-font size="2"><-family: '맑은 고딕'; mso-fareast-font face="-family: '맑은 고딕">2'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12. People who would like to acquire further information about the data for research publication and collaboration, please contact us. <o0pt; mso-color-index:p13"></o:pspan></fontspan></fontp></span></pstyle="margin-bottom: 0pt; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">The Genome Research Foundation should review and approve specifying the conditions under which data may be accepted, and ensuring adequate provisions to protect the privacy of subjects and maintain the confidentiality of data.</span></span></p style="margin: 0cm 0cm 0pt" class="MsoNormal"><span lang="EN-US"><font size="2" face="맑은 고딕">Contact: info@kpgp.kr <p style="margin-bottom: 0pt; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">To cite the data source in any publications or research based upon these data, and to provide a copy of any publications, the following citation should be included in any research reports, papers, or publications based on these data:</span></span></p><p style="margin-bottom: 0pt; unicode-bidi: embed; direction: ltr; text-align: left; margin-left: 0in; margin-top: 0pt; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Produced and distributed data should have references in Acknowledgement, Methods, Abstract. </span></span></p><h2>How to download</h2><p><span style="font-size: small">After accessing to the OPEN KPGP website, select the desired data from DATA DOWNLOAD to download it through the Web and FTP. <br />Please understand that the downloading may be very slow due to Network load. (The speed of downloading 20 people’s data through KT cloud is stable, please use it as an alternative.)</span></p><p> </p><h2>Hard disk request</h2><p><span style="font-size: small">You can get data hard disks by requesting it to the administrator. However, the hard disk and processing costs will occur. <br />Cost:</span></p><ul> <li><span style="font-size: small">Hard disks</span></li> <li><span style="font-size: small">Operating costs (labor and server equipment operating costs). </span></li> <li><span style="font-size: small">Shipping : door to door delivery(domestic only) / international shipping : please contact. (</span><a href="mailto:info@kpgp.kr"><span style="font-size: small">info@kpgp.kr</span></a><span style="font-size: small">) </span><span style="font-size: small"> </span></li></ul><p><span style="font-size: small"><span lang="EN-US"><font size="2" face="맑은 고딕">(The data charges are variable based on the quantity and price of the hard disk, one hard disk can contain different numbers of samples.) </font></span></span></p><p><span style="font-size: small">1) Raw sequencing data</span></p><table style="height: 95px; width: 242px" cellspacing="1" cellpadding="1" width="242" border="1"> <tbody> <tr> <td>Sample no.</td> <td>Cost(excluding V.A.T)</td> </tr> <tr> <td>~10</td> <td>115,000 (KRW) </td> </tr> <tr> <td>~20</td> <td>170,000 (KRW)</td> </tr> <tr> <td>~30</td> <td>260,000 (KRW)</td> </tr> <tr> <td>~40</td> <td>340,000 (KRW)</td> </tr> </tbody></table><p> 2) Data included : raw sequencing data, aligned data, genome variation, nonsynonymous SNVs</p><p><table style="height: 95px; width: 242px" cellspacing="1" cellpadding="1" width="242" border="1"> <tbody> <tr> <td>Sample no.</td> <td>Cost(excluding V.A.T)</td> </tr> <tr> <td>~10</td> <td>310,000 (KRW) </td> </tr> <tr> <td>~20</td> <td>530,000 (KRW) </td> </tr> <tr> <td>~30</td> <td>750,000 (KRW)</td> </tr> <tr> <td>~40</td> <td>880,000 (KRW)</td> </tr> </tbody></table></p><p> Date for pricing: 2011.09</p><h2><span id="1..C2.A0Sample.28gDNA.29_Preparation" class="mw-headline">Method of Sample (gDNA) Preparation for Sending out</span> </h2><p><span style="font-size: small"><b><span id="1..C2.A0Sample.28gDNA.29_Preparation" class="mw-headline">1. Sample(gDNA) Preparation</span></b></span></p><p><span style="font-size: small">1) DNA should be dissolved in TE buffer (Tris 10mM pH 8,0, 0.1 mM EDTA) or 10 mM Tris pH 8.0.</span></p><p><span style="font-size: small">2) Do Not Dissolve in Water</span></p><p> </p><p><b><span style="font-size: small"><span id="2..C2.A0Sample.28gDNA.29_Requirement" class="mw-headline">2. Sample(gDNA) Requirement</span></span></b></p><p><span style="font-size: small">1) Amount and concentration spec. : over 20 ug of gDNA with >50 ng/ul</span></p><p><span style="font-size: small"> This amount is required for</span></p><p><span style="font-size: small">a. Whole genome sequencing (30X)</span></p><p><span style="font-size: small">b. Whole exome sequencing (50X)</span></p><p><span style="font-size: small">c. Genotyping</span></p><p><span style="font-size: small">2) Sample(gDNA) should be : OD260/280=1.8~2.0; free of protein, RNA, or other visible contamination</span></p><p><span style="font-size: small"> </span></p><p><b><span style="font-size: small"><span id="3..C2.A0Sample.28gDNA.29_Packing_Information.C2.A0" class="mw-headline">3. Sample(gDNA) Packing Information </span></span></b></p><p><span style="font-size: small">This way is only available when DNA is dissolved in TE or Tris buffer.</span></p><p><span style="font-size: small">1) If not, please pack DNA with icepack in icebox and use Fedex or DHL service</span></p><p><span style="font-size: small">2) Mark sample information on tube (concentration, sample name…what you want)</span></p><p><span style="font-size: small">3) Seal the cap of tube with parafilm well</span></p><p><span style="font-size: small">4) Wrap the tube with paper towel or equivalent</span></p><p><span style="font-size: small">5) Put into the 50 ml Falcon tube and close the cap</span></p><p><span style="font-size: small">6) Send the sample with air cushion envelop by FEDEX or DHL or equivalent</span></p><p> </p><p><b><span style="font-size: small"><span id="4..C2.A0Requirement_of_Sample.28gDNA.29_Information" class="mw-headline">4. Requirement of Sample(gDNA) Information</span></span></b></p><p>1) Sample type: DNA</p><p>2) Condition: DNA in TE buffer or EB buffer or equivalent. Not in water</p><p>3) Gel image of DNA electrophoresis</p><p>4) Species</p><p>5) No. of Tubes</p><p>6) Concentration (ng/μl)</p><p>7) Volume (μl)</p><p>8) Total Quantity (μg)</p><p>9) OD260/280</p><p>10) OD260/230</p><p> </p><p><b><span style="font-size: medium">Please download and refer to the following documents for information on gDNA methods of preparation and delivery.</span></b></p><p>1.<span style="color: #800000"><a href="/userfiles/Method of Sample(gDNA) Preparation for Sending out.doc">Method of Sample (gDNA) Preparation for Sending out</a></span></p><p>2.<span style="color: #800000"><a href="/userfiles/Declaration_of_Shipment_for_anyone(2).doc">Declaration of Shipment</a><br /> </span></p><p> </p><h2>How it works</h2><p> </p><p><img alt="" width="840" height="728" src="/userfiles/chart1(1).gif" /></p><p> </p><p> </p><p><br /> <br /><span style="font-size: medium">Data Usage </span><br />1. The genome data is provided by Genome Research Foundation. Anyone can use the data freely.</p><p>2. People who would like to acquire further information about the data for research publication and collaboration, please contact us. <br />Contact: <a href="mailto:info@pgi.re.kr">info@pgi.re.kr</a> / 82-3143-888235-9327</font></span>8687</p>
<p> </p>