Changes

<p>Genome Research Foundation (GRF), as a non-<span style="font-size: larger">profit foundation, determines </span>to open Korean genome data and the current available data of human genome sequence and analysis for free to allow researchers to study. Under the circumstances, OPEN KPGP started on 2011.</p>

<p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">1) Data Type</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Every derived genetic information should be approved by relevant facility board.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-familysize: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">1. Genetic information data- Individual's sequenced DNA and analyzed data.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">2. Clinical information data- Clinical information does not include family tree, Phenotype and family medical history.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-familysize: 'larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">2) The Commission Process</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">1. Bioethics committee of Genome Research Foundation will make a decision through policy reviews and case consultation.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-familysize: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">2. The Standards Commission</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">This commission should be controlled by Korea National Institute for Bioethics Policy.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-familysize: 'larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Research, associate with potential social risks, </span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">eugenical</span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13"> problem and discrimination on the basis of genetic information when it comes to any aspects of physical looking, should be forbidden. </span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; languagelanguage: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">3. The Commission Process</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Research project and IRB document, approved in each countries, will be required. If there is no provision for IRB approval, User must agree with additional consent documents that embodies the purpose of the data.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">4. Evaluation (It will take at least one week)</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">3) Policy </span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Agrement</span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13"> </span> </span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-familysize: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Informed consent shall be documented by the use of a written consent form approved by the IRB, and signed by the subject or the subject's legally </span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">authourized</span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13"> representative.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">And if necessary, the committee may request, require or otherwise obtain detailed investigation.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Data Release</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; languagelanguage: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Any additional costs to the subject that may result from participation in the research.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">4) Data Source </span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Agrement</span><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; font-weight: bold; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13"> </span> </span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-familysize: 'larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">The Genome Research Foundation should review and approve specifying the conditions under which data may be accepted, and ensuring adequate provisions to protect the privacy of subjects and maintain the confidentiality of data.</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">To cite the data source in any publications or research based upon these data, and to provide a copy of any publications, the following citation should be included in any research reports, papers, or publications based on these data:</span></span></p><p style="text-align: left; margin-top: 0pt; unicode-bidi: embed; direction: ltr; margin-bottom: 0pt; margin-left: 0in; language: ko; mso-line-break-override: none; punctuation-wrap: hanging"><span style="font-size: larger"><span style="font-family: '맑은 고딕'; color: black; font-size: 11pt; language: en-US; mso-ascii-font-family: '맑은 고딕'; mso-fareast-font-family: '맑은 고딕'; mso-bidi-font-family: +mn-cs; mso-font-kerning: 12.0pt; mso-color-index: 13">Produced and distributed data should have references in Acknowledgement, Methods, Abstract. </span></span></p>